GBV-C/HGV coinfection in HIV-1-positive men: Frequent detection of viral RNA in blood plasma but absence from seminal fluid plasma

Sequential paired samples of blood and seminal fluid were obtained from a cohort of 54 HIV‐1‐infected homosexual males. The prevalence of GBV‐C/HGV RNA in the cell‐free fractions of some of these patients was determined using reverse‐transcription polymerase chain reaction (RT‐PCR). To assess the ef...

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Veröffentlicht in:Journal of medical virology 1998-12, Vol.56 (4), p.321-326
Hauptverfasser: Hollingsworth, Rosalind C., Jameson, Claire L., Minton, Jane E., Crowe, Mary, Curran, Rebecca, Rowe, Tessa, Grabowska, Anna M., Pillay, Deenan, Irving, Will L., Ball, Jonathan K.
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container_issue 4
container_start_page 321
container_title Journal of medical virology
container_volume 56
creator Hollingsworth, Rosalind C.
Jameson, Claire L.
Minton, Jane E.
Crowe, Mary
Curran, Rebecca
Rowe, Tessa
Grabowska, Anna M.
Pillay, Deenan
Irving, Will L.
Ball, Jonathan K.
description Sequential paired samples of blood and seminal fluid were obtained from a cohort of 54 HIV‐1‐infected homosexual males. The prevalence of GBV‐C/HGV RNA in the cell‐free fractions of some of these patients was determined using reverse‐transcription polymerase chain reaction (RT‐PCR). To assess the effects of HIV‐1 and HCV infection upon GBV‐C/HGV RNA status, blood CD4 cell counts, HCV RNA status, and HIV‐1 proviral DNA and viral RNA titres were also determined. GBV‐C/HGV RNA was detected in 8/30 (27%) of the blood plasma samples obtained at the start of the study, and was present at a frequency of 14/64 (22%) in all the blood plasma samples tested. By contrast, GBV‐C/HGV RNA was not detected in the 26 seminal fluid samples obtained at the start of the study, including 8 samples obtained from patients for which GBV‐C/HGV RNA was detected in the corresponding blood sample. Of the samples tested for the presence of both GBV‐C/HGV and HCV RNA, there was no evidence of coinfection. Although GBV‐C/HGV RNA detection rates were significantly higher in individuals with blood CD4 cell counts greater than 200 cells per microlitre, there were no significant differences in the median blood CD4 cell counts or HIV‐1 proviral DNA or viral RNA titres observed between the GBV‐C/HGV‐positive and ‐negative individuals. The failure to detect GBV‐C/HGV RNA in seminal fluid samples obtained from this cohort would suggest that further studies need to be carried out to determine the roles of sexual transmission and of seminal fluid in GBV‐C/HGV infection. J. Med. Virol. 56:321–326, 1998. © 1998 Wiley‐Liss, Inc.
doi_str_mv 10.1002/(SICI)1096-9071(199812)56:4<321::AID-JMV6>3.0.CO;2-V
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The prevalence of GBV‐C/HGV RNA in the cell‐free fractions of some of these patients was determined using reverse‐transcription polymerase chain reaction (RT‐PCR). To assess the effects of HIV‐1 and HCV infection upon GBV‐C/HGV RNA status, blood CD4 cell counts, HCV RNA status, and HIV‐1 proviral DNA and viral RNA titres were also determined. GBV‐C/HGV RNA was detected in 8/30 (27%) of the blood plasma samples obtained at the start of the study, and was present at a frequency of 14/64 (22%) in all the blood plasma samples tested. By contrast, GBV‐C/HGV RNA was not detected in the 26 seminal fluid samples obtained at the start of the study, including 8 samples obtained from patients for which GBV‐C/HGV RNA was detected in the corresponding blood sample. Of the samples tested for the presence of both GBV‐C/HGV and HCV RNA, there was no evidence of coinfection. Although GBV‐C/HGV RNA detection rates were significantly higher in individuals with blood CD4 cell counts greater than 200 cells per microlitre, there were no significant differences in the median blood CD4 cell counts or HIV‐1 proviral DNA or viral RNA titres observed between the GBV‐C/HGV‐positive and ‐negative individuals. The failure to detect GBV‐C/HGV RNA in seminal fluid samples obtained from this cohort would suggest that further studies need to be carried out to determine the roles of sexual transmission and of seminal fluid in GBV‐C/HGV infection. J. Med. 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Psychology ; GBV-C/HGV ; Hepacivirus - isolation &amp; purification ; Hepatitis C - complications ; Hepatitis C - transmission ; Hepatitis G virus ; Hepatitis, Viral, Human - epidemiology ; Hepatitis, Viral, Human - transmission ; Hepatitis, Viral, Human - virology ; HIV Infections - complications ; HIV Infections - immunology ; HIV Infections - virology ; HIV-1 ; HIV-1 - isolation &amp; purification ; Homosexuality, Male ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Prevalence ; Proviruses ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Viral - blood ; RT-PCR ; Semen - virology ; seminal fluid ; sexual transmission ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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Med. Virol</addtitle><description>Sequential paired samples of blood and seminal fluid were obtained from a cohort of 54 HIV‐1‐infected homosexual males. The prevalence of GBV‐C/HGV RNA in the cell‐free fractions of some of these patients was determined using reverse‐transcription polymerase chain reaction (RT‐PCR). To assess the effects of HIV‐1 and HCV infection upon GBV‐C/HGV RNA status, blood CD4 cell counts, HCV RNA status, and HIV‐1 proviral DNA and viral RNA titres were also determined. GBV‐C/HGV RNA was detected in 8/30 (27%) of the blood plasma samples obtained at the start of the study, and was present at a frequency of 14/64 (22%) in all the blood plasma samples tested. By contrast, GBV‐C/HGV RNA was not detected in the 26 seminal fluid samples obtained at the start of the study, including 8 samples obtained from patients for which GBV‐C/HGV RNA was detected in the corresponding blood sample. Of the samples tested for the presence of both GBV‐C/HGV and HCV RNA, there was no evidence of coinfection. Although GBV‐C/HGV RNA detection rates were significantly higher in individuals with blood CD4 cell counts greater than 200 cells per microlitre, there were no significant differences in the median blood CD4 cell counts or HIV‐1 proviral DNA or viral RNA titres observed between the GBV‐C/HGV‐positive and ‐negative individuals. The failure to detect GBV‐C/HGV RNA in seminal fluid samples obtained from this cohort would suggest that further studies need to be carried out to determine the roles of sexual transmission and of seminal fluid in GBV‐C/HGV infection. J. Med. Virol. 56:321–326, 1998. © 1998 Wiley‐Liss, Inc.</description><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>Cohort Studies</subject><subject>DNA, Viral - analysis</subject><subject>Epidemiology</subject><subject>Flaviviridae - isolation &amp; purification</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GBV-C/HGV</subject><subject>Hepacivirus - isolation &amp; purification</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - transmission</subject><subject>Hepatitis G virus</subject><subject>Hepatitis, Viral, Human - epidemiology</subject><subject>Hepatitis, Viral, Human - transmission</subject><subject>Hepatitis, Viral, Human - virology</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV-1</subject><subject>HIV-1 - isolation &amp; purification</subject><subject>Homosexuality, Male</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Prevalence</subject><subject>Proviruses</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Viral - blood</subject><subject>RT-PCR</subject><subject>Semen - virology</subject><subject>seminal fluid</subject><subject>sexual transmission</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral hepatitis</subject><subject>Virology</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1v0zAUhiMEGmXwE5B8gdB2kc4fiR2XCakLrO20rRKUcHnkOLZklo8Sp_u45ZeT0NJdgDTfHFnnPe95j54gOCV4TDCmJ0dfF-nimGDJQ4kFOSJSJoQex3wSnTJKJpPp4lN4cZXxj2yMx-nyAw2zZ8FoP_A8GGES8ZBzEr8MXnn_A2OcSEoPggOZUMkZHwW_ZmdZmJ7MZxnSjaut0Z1rauRqNF9kIQnXjXeduzWoMvUEnbfm58bUHSpMt1M2Ft26VpXoy_V0GMvLpinQulS-UijfdEjl3tTaINs2FfKmcnUvtuXG_VW9Dl5YVXrzZlcPg2_nn1fpPLxczhbp9DLUUZz0Z0htrcUxZomxseKUsEJLU-gkVv0jRS40LTCjSibKMCloQXkuCGFREWks2GHwfuu7bpv-Ct9B5bw2Zalq02w8CIx5RIR8UkgEoVzKQbjaCnXbeN8aC-vWVap9AIJhYAgwMIQBCQxIYMsQYg4R9AwBeoYwMAQGGNIlUMh627e7_Zu8MsXedAet77_b9ZXXqrStqrXzj7s5EZTFj-nuXGke_on2RLL_BPvz723Dra3znbnf26r2BrhgIobv1zO4SFdnaSJmcMV-AxY30hQ</recordid><startdate>199812</startdate><enddate>199812</enddate><creator>Hollingsworth, Rosalind C.</creator><creator>Jameson, Claire L.</creator><creator>Minton, Jane E.</creator><creator>Crowe, Mary</creator><creator>Curran, Rebecca</creator><creator>Rowe, Tessa</creator><creator>Grabowska, Anna M.</creator><creator>Pillay, Deenan</creator><creator>Irving, Will L.</creator><creator>Ball, Jonathan K.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199812</creationdate><title>GBV-C/HGV coinfection in HIV-1-positive men: Frequent detection of viral RNA in blood plasma but absence from seminal fluid plasma</title><author>Hollingsworth, Rosalind C. ; Jameson, Claire L. ; Minton, Jane E. ; Crowe, Mary ; Curran, Rebecca ; Rowe, Tessa ; Grabowska, Anna M. ; Pillay, Deenan ; Irving, Will L. ; Ball, Jonathan K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4586-69cfff05038ef5a6213dc9edc85aaaa1db7c2d032a98ae3972d26b71134d4c073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>Cohort Studies</topic><topic>DNA, Viral - analysis</topic><topic>Epidemiology</topic><topic>Flaviviridae - isolation &amp; purification</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GBV-C/HGV</topic><topic>Hepacivirus - isolation &amp; purification</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - transmission</topic><topic>Hepatitis G virus</topic><topic>Hepatitis, Viral, Human - epidemiology</topic><topic>Hepatitis, Viral, Human - transmission</topic><topic>Hepatitis, Viral, Human - virology</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - virology</topic><topic>HIV-1</topic><topic>HIV-1 - isolation &amp; purification</topic><topic>Homosexuality, Male</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Prevalence</topic><topic>Proviruses</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Viral - blood</topic><topic>RT-PCR</topic><topic>Semen - virology</topic><topic>seminal fluid</topic><topic>sexual transmission</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral hepatitis</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hollingsworth, Rosalind C.</creatorcontrib><creatorcontrib>Jameson, Claire L.</creatorcontrib><creatorcontrib>Minton, Jane E.</creatorcontrib><creatorcontrib>Crowe, Mary</creatorcontrib><creatorcontrib>Curran, Rebecca</creatorcontrib><creatorcontrib>Rowe, Tessa</creatorcontrib><creatorcontrib>Grabowska, Anna M.</creatorcontrib><creatorcontrib>Pillay, Deenan</creatorcontrib><creatorcontrib>Irving, Will L.</creatorcontrib><creatorcontrib>Ball, Jonathan K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hollingsworth, Rosalind C.</au><au>Jameson, Claire L.</au><au>Minton, Jane E.</au><au>Crowe, Mary</au><au>Curran, Rebecca</au><au>Rowe, Tessa</au><au>Grabowska, Anna M.</au><au>Pillay, Deenan</au><au>Irving, Will L.</au><au>Ball, Jonathan K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GBV-C/HGV coinfection in HIV-1-positive men: Frequent detection of viral RNA in blood plasma but absence from seminal fluid plasma</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>1998-12</date><risdate>1998</risdate><volume>56</volume><issue>4</issue><spage>321</spage><epage>326</epage><pages>321-326</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>Sequential paired samples of blood and seminal fluid were obtained from a cohort of 54 HIV‐1‐infected homosexual males. The prevalence of GBV‐C/HGV RNA in the cell‐free fractions of some of these patients was determined using reverse‐transcription polymerase chain reaction (RT‐PCR). To assess the effects of HIV‐1 and HCV infection upon GBV‐C/HGV RNA status, blood CD4 cell counts, HCV RNA status, and HIV‐1 proviral DNA and viral RNA titres were also determined. GBV‐C/HGV RNA was detected in 8/30 (27%) of the blood plasma samples obtained at the start of the study, and was present at a frequency of 14/64 (22%) in all the blood plasma samples tested. By contrast, GBV‐C/HGV RNA was not detected in the 26 seminal fluid samples obtained at the start of the study, including 8 samples obtained from patients for which GBV‐C/HGV RNA was detected in the corresponding blood sample. Of the samples tested for the presence of both GBV‐C/HGV and HCV RNA, there was no evidence of coinfection. Although GBV‐C/HGV RNA detection rates were significantly higher in individuals with blood CD4 cell counts greater than 200 cells per microlitre, there were no significant differences in the median blood CD4 cell counts or HIV‐1 proviral DNA or viral RNA titres observed between the GBV‐C/HGV‐positive and ‐negative individuals. The failure to detect GBV‐C/HGV RNA in seminal fluid samples obtained from this cohort would suggest that further studies need to be carried out to determine the roles of sexual transmission and of seminal fluid in GBV‐C/HGV infection. J. Med. Virol. 56:321–326, 1998. © 1998 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9829636</pmid><doi>10.1002/(SICI)1096-9071(199812)56:4&lt;321::AID-JMV6&gt;3.0.CO;2-V</doi><tpages>6</tpages></addata></record>
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subjects AIDS/HIV
Biological and medical sciences
CD4 Lymphocyte Count
Cohort Studies
DNA, Viral - analysis
Epidemiology
Flaviviridae - isolation & purification
Fundamental and applied biological sciences. Psychology
GBV-C/HGV
Hepacivirus - isolation & purification
Hepatitis C - complications
Hepatitis C - transmission
Hepatitis G virus
Hepatitis, Viral, Human - epidemiology
Hepatitis, Viral, Human - transmission
Hepatitis, Viral, Human - virology
HIV Infections - complications
HIV Infections - immunology
HIV Infections - virology
HIV-1
HIV-1 - isolation & purification
Homosexuality, Male
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Microbiology
Prevalence
Proviruses
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - blood
RT-PCR
Semen - virology
seminal fluid
sexual transmission
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral hepatitis
Virology
title GBV-C/HGV coinfection in HIV-1-positive men: Frequent detection of viral RNA in blood plasma but absence from seminal fluid plasma
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