Identification of Morc (Microrchidia), a Mutation that Results in Arrest of Spermatogenesis at an Early Meiotic Stage in the Mouse

The microrchidia, or morc, autosomal recessive mutation results in the arrest of spermatogenesis early in prophase I of meiosis. The morc mutation arose spontaneously during the development of a mouse strain transgenic for a tyrosinase cDNA construct. Morc -/- males are infertile and have grossly re...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-11, Vol.95 (24), p.14361-14366
Hauptverfasser:	Watson, Mark L., Zinn, Andrew R., Inoue, Norimitsu, Hess, Karl D., Cobb, John, Handel, Mary Ann, Halaban, Ruth, Duchene, Clark C., Albright, George M., Moreadith, Randall W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Base Sequence Biochemistry Biological Sciences DNA Primers Eye Color - genetics Gene Deletion Genes, Recessive Genetic mutation Genetics Germ cells Infertility, Male - genetics Infertility, Male - pathology Male Meiosis Mice Mice, Inbred Strains Mice, Transgenic Molecular Sequence Data Mutation Phenotypes Polymerase Chain Reaction Prophase Regulatory Sequences, Nucleic Acid Retina - physiology RNA Polymerase II - genetics Rodents Spermatocytes Spermatogenesis Spermatogenesis - genetics Spermatozoa - cytology Spermatozoa - physiology Testes Testis - abnormalities Testis - pathology Transgenes
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