$Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women$

Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women

High bone resorption by the osteoclast results in osteoporosis, a disease affecting 40% of women after the menopause. Calcitonin, used to treat osteoporosis, inhibits bone resorption via receptors located on the osteoclasts. Two alleles of the calcitonin receptor gene ( CTR ) exist: a base mutation...

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Veröffentlicht in:	Human molecular genetics 1998-12, Vol.7 (13), p.2129-2133
Hauptverfasser:	TABOULET, J, FRENKIAN, M, FRENDO, J. L, FEINGOLD, N, JULLIENNE, A, DE VERNEJOUL, M. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alleles Amino Acid Substitution Analysis of Variance Biological and medical sciences Body Weight Bone Density Cohort Studies Diseases of the osteoarticular system DNA - analysis DNA - genetics Female Fractures, Bone - metabolism Genotype HL-60 Cells Humans Medical sciences Middle Aged Osteoporosis, Postmenopausal - genetics Osteoporosis. Osteomalacia. Paget disease Point Mutation Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Single-Stranded Conformational Postmenopause - genetics Receptors, Calcitonin - genetics Risk Factors Transcription, Genetic Tumor Cells, Cultured
Online-Zugang:	Volltext
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