Clinical utility of pH paper versus pH meter in the measurement of critical gastric pH in stress ulcer prophylaxis

OBJECTIVETo evaluate the clinical utility of measuring gastric pH with a pH meter vs. pH paper in critical care patients. DESIGNProspective comparison of gastric pH measurements, using both pH meter and pH paper. SETTINGSurgical intensive care unit (ICU) at a rural Midwestern university medical cent...

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Veröffentlicht in:Critical care medicine 1998-11, Vol.26 (11), p.1905-1909
Hauptverfasser: Bradley, J. Shane, Phillips, Jeffrey O, Cavanaugh, Joseph E, Metzler, Michael H
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container_end_page 1909
container_issue 11
container_start_page 1905
container_title Critical care medicine
container_volume 26
creator Bradley, J. Shane
Phillips, Jeffrey O
Cavanaugh, Joseph E
Metzler, Michael H
description OBJECTIVETo evaluate the clinical utility of measuring gastric pH with a pH meter vs. pH paper in critical care patients. DESIGNProspective comparison of gastric pH measurements, using both pH meter and pH paper. SETTINGSurgical intensive care unit (ICU) at a rural Midwestern university medical center. PATIENTSFifty-one patients who received therapy for prophylaxis of stress ulcers in the surgical ICU. INTERVENTIONSTherapy for stress ulcer prophylaxis was monitored. MEASUREMENTS AND MAIN RESULTSThe pH of 985 gastric samples, taken from 51 patients, was measured with both pH meter and pH paper. The pH meter and pH paper measures demonstrated a concordance correlation coefficient of .896. The mean difference between the two measures (pH paper - pH meter) was estimated to be between -0.4 and 1.4, suggesting a positive bias for the paper. The prevalence of events representing clinically relevant differences between the pH meter and pH paper in the measurement of the same gastric sample was calculated. The frequency with which each of the events occurred consecutively (or, in one case, two nearly consecutive events on the same day) was also calculated. Bias in a clinically relevant range was estimated. A set of "probability profiles" was constructed. CONCLUSIONSA hand-held pH meter and pH paper are not inter-changeable measures of gastric pH. The pH paper exhibits an appreciable positive bias compared with a hand-held pH meter in the clinically relevant range of 2 to 6. More research is needed to determine if that bias affects treatment outcomes. We recommend the use of a pH meter for patients who demonstrate pH readings of
doi_str_mv 10.1097/00003246-199811000-00037
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Shane ; Phillips, Jeffrey O ; Cavanaugh, Joseph E ; Metzler, Michael H</creator><creatorcontrib>Bradley, J. Shane ; Phillips, Jeffrey O ; Cavanaugh, Joseph E ; Metzler, Michael H</creatorcontrib><description>OBJECTIVETo evaluate the clinical utility of measuring gastric pH with a pH meter vs. pH paper in critical care patients. DESIGNProspective comparison of gastric pH measurements, using both pH meter and pH paper. SETTINGSurgical intensive care unit (ICU) at a rural Midwestern university medical center. PATIENTSFifty-one patients who received therapy for prophylaxis of stress ulcers in the surgical ICU. INTERVENTIONSTherapy for stress ulcer prophylaxis was monitored. MEASUREMENTS AND MAIN RESULTSThe pH of 985 gastric samples, taken from 51 patients, was measured with both pH meter and pH paper. The pH meter and pH paper measures demonstrated a concordance correlation coefficient of .896. The mean difference between the two measures (pH paper - pH meter) was estimated to be between -0.4 and 1.4, suggesting a positive bias for the paper. The prevalence of events representing clinically relevant differences between the pH meter and pH paper in the measurement of the same gastric sample was calculated. The frequency with which each of the events occurred consecutively (or, in one case, two nearly consecutive events on the same day) was also calculated. Bias in a clinically relevant range was estimated. A set of "probability profiles" was constructed. CONCLUSIONSA hand-held pH meter and pH paper are not inter-changeable measures of gastric pH. The pH paper exhibits an appreciable positive bias compared with a hand-held pH meter in the clinically relevant range of 2 to 6. More research is needed to determine if that bias affects treatment outcomes. We recommend the use of a pH meter for patients who demonstrate pH readings of &lt;or=to4, consecutive with readings of &lt;or=to5. (Crit Care Med 1998; 26:1905-1909)</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-199811000-00037</identifier><identifier>PMID: 9824087</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: Williams &amp; Wilkins</publisher><subject>Adult ; Biological and medical sciences ; Calibration ; Evaluation Studies as Topic ; Female ; Gastric Acidity Determination - instrumentation ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Hydrogen-Ion Concentration ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Prospective Studies ; Statistics as Topic ; Stomach Ulcer - etiology ; Stomach Ulcer - physiopathology ; Stomach Ulcer - prevention &amp; control ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Stress, Psychological - complications ; Stress, Psychological - physiopathology ; Stress, Psychological - prevention &amp; control</subject><ispartof>Critical care medicine, 1998-11, Vol.26 (11), p.1905-1909</ispartof><rights>Williams &amp; Wilkins 1998. All Rights Reserved.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3847-45b7ff8aa7cff91845e867f57a23a245d22862ea041a602496bd9365a942842b3</citedby><cites>FETCH-LOGICAL-c3847-45b7ff8aa7cff91845e867f57a23a245d22862ea041a602496bd9365a942842b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1597480$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9824087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bradley, J. Shane</creatorcontrib><creatorcontrib>Phillips, Jeffrey O</creatorcontrib><creatorcontrib>Cavanaugh, Joseph E</creatorcontrib><creatorcontrib>Metzler, Michael H</creatorcontrib><title>Clinical utility of pH paper versus pH meter in the measurement of critical gastric pH in stress ulcer prophylaxis</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>OBJECTIVETo evaluate the clinical utility of measuring gastric pH with a pH meter vs. pH paper in critical care patients. DESIGNProspective comparison of gastric pH measurements, using both pH meter and pH paper. SETTINGSurgical intensive care unit (ICU) at a rural Midwestern university medical center. PATIENTSFifty-one patients who received therapy for prophylaxis of stress ulcers in the surgical ICU. INTERVENTIONSTherapy for stress ulcer prophylaxis was monitored. MEASUREMENTS AND MAIN RESULTSThe pH of 985 gastric samples, taken from 51 patients, was measured with both pH meter and pH paper. The pH meter and pH paper measures demonstrated a concordance correlation coefficient of .896. The mean difference between the two measures (pH paper - pH meter) was estimated to be between -0.4 and 1.4, suggesting a positive bias for the paper. The prevalence of events representing clinically relevant differences between the pH meter and pH paper in the measurement of the same gastric sample was calculated. The frequency with which each of the events occurred consecutively (or, in one case, two nearly consecutive events on the same day) was also calculated. Bias in a clinically relevant range was estimated. A set of "probability profiles" was constructed. CONCLUSIONSA hand-held pH meter and pH paper are not inter-changeable measures of gastric pH. The pH paper exhibits an appreciable positive bias compared with a hand-held pH meter in the clinically relevant range of 2 to 6. More research is needed to determine if that bias affects treatment outcomes. We recommend the use of a pH meter for patients who demonstrate pH readings of &lt;or=to4, consecutive with readings of &lt;or=to5. (Crit Care Med 1998; 26:1905-1909)</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Calibration</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Gastric Acidity Determination - instrumentation</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Prospective Studies</subject><subject>Statistics as Topic</subject><subject>Stomach Ulcer - etiology</subject><subject>Stomach Ulcer - physiopathology</subject><subject>Stomach Ulcer - prevention &amp; control</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Stress, Psychological - complications</subject><subject>Stress, Psychological - physiopathology</subject><subject>Stress, Psychological - prevention &amp; control</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU2PFCEQhonRrOO6P8GkD8ZbK1_dwNFM1DXZxMvumdQwsIPSH1K06_x76Z1xPckFXniqKnkgpGH0PaNGfaB1CS77lhmjGaupXW_UM7JhnaiBG_GcbCg1tBXSiJfkFeJ3SpnslLggF0ZzSbXakLxNcYwOUrOUmGI5NlNo5utmhtnn5pfPuOCaB19qjmNTDr4GwCX7wY9lxV2O5bHFPWDJ0a18JevZIzZLcrVyztN8OCb4HfE1eREgob8675fk7vOn2-11e_Pty9ftx5vWCS1VK7udCkEDKBeCYVp2XvcqdAq4AC67Pee65x6oZNBTLk2_2xvRd2Ak15LvxCV5d-pbZ_9cPBY7RHQ-JRj9tKBVlPZMUFNBfQJdnhCzD3bOcYB8tIzaVbf9q9s-6baPumvpm_OMZTf4_VPh2W99f3t-B6yGQobRRfzXvzNKaloxecIeplQ944-0PPhsDx5SOdj_fbb4A8cEl0g</recordid><startdate>199811</startdate><enddate>199811</enddate><creator>Bradley, J. Shane</creator><creator>Phillips, Jeffrey O</creator><creator>Cavanaugh, Joseph E</creator><creator>Metzler, Michael H</creator><general>Williams &amp; Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199811</creationdate><title>Clinical utility of pH paper versus pH meter in the measurement of critical gastric pH in stress ulcer prophylaxis</title><author>Bradley, J. Shane ; Phillips, Jeffrey O ; Cavanaugh, Joseph E ; Metzler, Michael H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3847-45b7ff8aa7cff91845e867f57a23a245d22862ea041a602496bd9365a942842b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Calibration</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Gastric Acidity Determination - instrumentation</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Prospective Studies</topic><topic>Statistics as Topic</topic><topic>Stomach Ulcer - etiology</topic><topic>Stomach Ulcer - physiopathology</topic><topic>Stomach Ulcer - prevention &amp; control</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Stress, Psychological - complications</topic><topic>Stress, Psychological - physiopathology</topic><topic>Stress, Psychological - prevention &amp; control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bradley, J. Shane</creatorcontrib><creatorcontrib>Phillips, Jeffrey O</creatorcontrib><creatorcontrib>Cavanaugh, Joseph E</creatorcontrib><creatorcontrib>Metzler, Michael H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bradley, J. Shane</au><au>Phillips, Jeffrey O</au><au>Cavanaugh, Joseph E</au><au>Metzler, Michael H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical utility of pH paper versus pH meter in the measurement of critical gastric pH in stress ulcer prophylaxis</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1998-11</date><risdate>1998</risdate><volume>26</volume><issue>11</issue><spage>1905</spage><epage>1909</epage><pages>1905-1909</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>OBJECTIVETo evaluate the clinical utility of measuring gastric pH with a pH meter vs. pH paper in critical care patients. DESIGNProspective comparison of gastric pH measurements, using both pH meter and pH paper. SETTINGSurgical intensive care unit (ICU) at a rural Midwestern university medical center. PATIENTSFifty-one patients who received therapy for prophylaxis of stress ulcers in the surgical ICU. INTERVENTIONSTherapy for stress ulcer prophylaxis was monitored. MEASUREMENTS AND MAIN RESULTSThe pH of 985 gastric samples, taken from 51 patients, was measured with both pH meter and pH paper. The pH meter and pH paper measures demonstrated a concordance correlation coefficient of .896. The mean difference between the two measures (pH paper - pH meter) was estimated to be between -0.4 and 1.4, suggesting a positive bias for the paper. The prevalence of events representing clinically relevant differences between the pH meter and pH paper in the measurement of the same gastric sample was calculated. The frequency with which each of the events occurred consecutively (or, in one case, two nearly consecutive events on the same day) was also calculated. Bias in a clinically relevant range was estimated. A set of "probability profiles" was constructed. CONCLUSIONSA hand-held pH meter and pH paper are not inter-changeable measures of gastric pH. The pH paper exhibits an appreciable positive bias compared with a hand-held pH meter in the clinically relevant range of 2 to 6. More research is needed to determine if that bias affects treatment outcomes. We recommend the use of a pH meter for patients who demonstrate pH readings of &lt;or=to4, consecutive with readings of &lt;or=to5. (Crit Care Med 1998; 26:1905-1909)</abstract><cop>Hagerstown, MD</cop><pub>Williams &amp; Wilkins</pub><pmid>9824087</pmid><doi>10.1097/00003246-199811000-00037</doi><tpages>5</tpages></addata></record>
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subjects Adult
Biological and medical sciences
Calibration
Evaluation Studies as Topic
Female
Gastric Acidity Determination - instrumentation
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hydrogen-Ion Concentration
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Prospective Studies
Statistics as Topic
Stomach Ulcer - etiology
Stomach Ulcer - physiopathology
Stomach Ulcer - prevention & control
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Stress, Psychological - complications
Stress, Psychological - physiopathology
Stress, Psychological - prevention & control
title Clinical utility of pH paper versus pH meter in the measurement of critical gastric pH in stress ulcer prophylaxis
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