Alterations in TCR-MHC Contacts Subsequent to Cross-Recognition of Class I MHC and Singly Substituted Peptide Variants

Vesicular stomatitis virus (VSV) elicits H-2Kb-restricted CTLs specific for the immunodominant VSV octapeptide RGYVYQGL. To study the structural features important for interaction between the TCR beta-chain and the peptide/MHC complex, we immunized TCR alpha-chain transgenic mice with the VSV peptid...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-11, Vol.161 (10), p.5454-5463
Hauptverfasser:	Ono, Toshiro, DiLorenzo, Teresa P, Wang, Fuming, Kalergis, Alexis M, Nathenson, Stanley G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Amino Acid Substitution - immunology Animals Cell Line Clone Cells Cytotoxicity, Immunologic - genetics H-2 Antigens - genetics H-2 Antigens - metabolism Ligands Mice Mice, Inbred C57BL Mice, Transgenic Models, Molecular Peptide Fragments - genetics Peptide Fragments - immunology Peptide Fragments - metabolism Receptors, Antigen, T-Cell, alpha-beta - biosynthesis Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - metabolism Sequence Homology, Amino Acid T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Vesicular stomatitis Indiana virus - immunology Viral Proteins - genetics Viral Proteins - immunology Viral Proteins - metabolism
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