Arrhythmogenic effects induced by coronary conversion of pulmonary big endothelin to endothelin : Aggravation of this phenomenon in heritable hyperlipidemia

We investigated whether endogenous pulmonary big endothelin has arrhythmogenic properties under normal conditions and in heritable hyperlipidemia. Endothelin (ET), one of the most potent vasoconstrictors, is known to induce ventricular arrhythmias. It is unclear, however, whether its precursor, big...

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Veröffentlicht in:	Journal of the American College of Cardiology 1998-11, Vol.32 (6), p.1773-1778
Hauptverfasser:	ALEXIOU, K, DSCHIETZIG, T, SIMSCH, O, LAULE, M, HUNDERTMARK, J, BAUMANN, G, STANGL, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid Endopeptidases - antagonists & inhibitors Biological and medical sciences Cardiac Complexes, Premature - etiology Cardiac Complexes, Premature - physiopathology Disorders of blood lipids. Hyperlipoproteinemia Endothelin-1 Endothelin-Converting Enzymes Endothelins - antagonists & inhibitors Endothelins - biosynthesis Endothelins - metabolism Glycopeptides - pharmacology Hyperlipidemias - complications Hyperlipidemias - genetics In Vitro Techniques Male Medical sciences Metabolic diseases Metalloendopeptidases Myocardium - metabolism Perfusion Protease Inhibitors - pharmacology Protein Precursors - metabolism Rabbits Tachycardia, Ventricular - etiology Tachycardia, Ventricular - physiopathology
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