Relationships between Reduction Properties and Cancer Cell Growth Inhibitory Activities of cis-Dichloro- and cis-Diiodo-Pt(IV)-ethylenediamines

The chemical reactivities and cancer cell growth inhibitory activities of a new series of cis‐diiodo‐Pt(IV)‐ethylenediamines were compared and contrasted with their cis‐dichloro‐Pt(IV)‐counterparts. cis‐Diiodo‐Pt(IV)‐ethylenediamines bearing various axial ligands (i.e., OH, OAc, OCOCF3, OSO2CH3) wer...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 1999-08, Vol.332 (8), p.279-285
Hauptverfasser:	Kratochwil, Nicole A., Bednarski, Patrick J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Biological and medical sciences cancer cells Cattle DNA DNA, Neoplasm - drug effects Ethylenediamines - chemical synthesis Ethylenediamines - chemistry Ethylenediamines - therapeutic use General aspects Humans Hydrocarbons, Halogenated - chemical synthesis Hydrocarbons, Halogenated - chemistry Hydrocarbons, Halogenated - therapeutic use Medical sciences Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - chemistry Organoplatinum Compounds - therapeutic use Pharmacology. Drug treatments pt(IV)-complexes reductions Stereoisomerism Structure-Activity Relationship thiols Tumor Cells, Cultured - drug effects
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