Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system

In Drosophila embryogenesis, the slit gene has been shown to play a critical role in CNS midline formation. However, no slit homologues have been reported in vertebrates. Here, we have identified mammalian homologues of the slit gene (human Slit-1, Slit-2, Slit-3, and rat Slit-1). Each Slit gene enc...

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Veröffentlicht in:	Brain research. Molecular brain research. 1998-11, Vol.62 (2), p.175-186
Hauptverfasser:	Itoh, Akira, Miyabayashi, Tomoyuki, Ohno, Mitsuharu, Sakano, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Central Nervous System - embryology Central Nervous System - growth & development Central Nervous System - metabolism Cloning, Molecular Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins EGF-like Embryonic and Fetal Development - genetics Evolution, Molecular Humans In Situ Hybridization Insect Proteins - biosynthesis Insect Proteins - genetics Insect Proteins - physiology Leucine-rich repeat Molecular Sequence Data Multigene Family Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Nervous System - embryology Nervous System - growth & development Nervous System - metabolism Organ Specificity Protein Isoforms - biosynthesis Protein Isoforms - genetics Protein Isoforms - physiology Rats - embryology Rats - genetics RNA, Messenger - biosynthesis Sequence Alignment Sequence Homology, Amino Acid Signal Transduction Slit Species Specificity Thyroid Gland - embryology Thyroid Gland - growth & development Thyroid Gland - metabolism
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