The Immune Response to Haemophilus ducreyi Resembles a Delayed-Type Hypersensitivity Reaction throughout Experimental Infection of Human Subjects
Previous work in 3 subjects infected for 2 weeks indicated that experimental infection with Haemophilus ducreyi recruits CD4 cells to the skin at the pustular stage of disease. In order to describe the kinetics of the host response, 23 subjects were infected at 2 sites with a standardized dose of H...
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| Veröffentlicht in: | The Journal of infectious diseases 1998-12, Vol.178 (6), p.1688-1697 |
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| container_title | The Journal of infectious diseases |
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| creator | Palmer, Katherine L. Schnizlein-Bick, Carol T. Orazi, Attilio John, Karla Chen, Cheng-Yen Hood, Antoinette F. Spinola, Stanley M. |
| description | Previous work in 3 subjects infected for 2 weeks indicated that experimental infection with Haemophilus ducreyi recruits CD4 cells to the skin at the pustular stage of disease. In order to describe the kinetics of the host response, 23 subjects were infected at 2 sites with a standardized dose of H ducreyi. Subjects were biopsied 1 or 4 days after inoculation or when they developed a painful pustular lesion (days 7–14). Papules and pustules contained a predominant T cell infiltrate that consisted of CD45RO and CD4 cells of the αβ lineage. Both papules and pustules contained mixed or T helper 1 type cytokine mRNA and interleukin-8 and tumor necrosis factor-α mRNA. Although the subjects had no history of chancroid, their immune responses resembled delayed-type hypersensitivity reactions that occurred within 24 h of inoculation and persisted throughout the course of experimental infection. |
| doi_str_mv | 10.1086/314489 |
| format | Article |
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In order to describe the kinetics of the host response, 23 subjects were infected at 2 sites with a standardized dose of H ducreyi. Subjects were biopsied 1 or 4 days after inoculation or when they developed a painful pustular lesion (days 7–14). Papules and pustules contained a predominant T cell infiltrate that consisted of CD45RO and CD4 cells of the αβ lineage. Both papules and pustules contained mixed or T helper 1 type cytokine mRNA and interleukin-8 and tumor necrosis factor-α mRNA. Although the subjects had no history of chancroid, their immune responses resembled delayed-type hypersensitivity reactions that occurred within 24 h of inoculation and persisted throughout the course of experimental infection.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/314489</identifier><identifier>PMID: 9815221</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: University Chicago Press</publisher><subject>Adult ; AIDS/HIV ; Antibodies ; Antibody Formation ; Antigens, CD - analysis ; B lymphocytes ; B-Lymphocytes - immunology ; Bacterial diseases ; Base Sequence ; Biological and medical sciences ; Biopsies ; Biopsy ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - pathology ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - pathology ; Chancroid - immunology ; Chancroid - pathology ; Cytokines ; Cytokines - genetics ; DNA Primers ; DNA Probes ; Experimental bacterial diseases and models ; Female ; Gene Expression Regulation ; Haemophilus ducreyi ; Haemophilus ducreyi - immunology ; Humans ; Hypersensitivity, Delayed ; Immunity, Cellular ; Infections ; Infectious diseases ; Inoculation ; Kinetics ; Lesions ; Major Article ; Male ; Medical sciences ; Messenger RNA ; RNA, Messenger - genetics ; Skin - immunology ; Skin - pathology ; T lymphocytes ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - pathology ; T-Lymphocytes - immunology ; Time Factors ; Transcription, Genetic</subject><ispartof>The Journal of infectious diseases, 1998-12, Vol.178 (6), p.1688-1697</ispartof><rights>Copyright 1998 Infectious Diseases Society of America</rights><rights>1999 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Dec 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-8c4b32df41f63b3bb66830bdbf2a99a7aa29621f9e3d1ae86e7adbdcb7205f803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30111472$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30111472$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1618556$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9815221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palmer, Katherine L.</creatorcontrib><creatorcontrib>Schnizlein-Bick, Carol T.</creatorcontrib><creatorcontrib>Orazi, Attilio</creatorcontrib><creatorcontrib>John, Karla</creatorcontrib><creatorcontrib>Chen, Cheng-Yen</creatorcontrib><creatorcontrib>Hood, Antoinette F.</creatorcontrib><creatorcontrib>Spinola, Stanley M.</creatorcontrib><title>The Immune Response to Haemophilus ducreyi Resembles a Delayed-Type Hypersensitivity Reaction throughout Experimental Infection of Human Subjects</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Previous work in 3 subjects infected for 2 weeks indicated that experimental infection with Haemophilus ducreyi recruits CD4 cells to the skin at the pustular stage of disease. In order to describe the kinetics of the host response, 23 subjects were infected at 2 sites with a standardized dose of H ducreyi. Subjects were biopsied 1 or 4 days after inoculation or when they developed a painful pustular lesion (days 7–14). Papules and pustules contained a predominant T cell infiltrate that consisted of CD45RO and CD4 cells of the αβ lineage. Both papules and pustules contained mixed or T helper 1 type cytokine mRNA and interleukin-8 and tumor necrosis factor-α mRNA. Although the subjects had no history of chancroid, their immune responses resembled delayed-type hypersensitivity reactions that occurred within 24 h of inoculation and persisted throughout the course of experimental infection.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Antibodies</subject><subject>Antibody Formation</subject><subject>Antigens, CD - analysis</subject><subject>B lymphocytes</subject><subject>B-Lymphocytes - immunology</subject><subject>Bacterial diseases</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biopsies</subject><subject>Biopsy</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - pathology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - pathology</subject><subject>Chancroid - immunology</subject><subject>Chancroid - pathology</subject><subject>Cytokines</subject><subject>Cytokines - genetics</subject><subject>DNA Primers</subject><subject>DNA Probes</subject><subject>Experimental bacterial diseases and models</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Haemophilus ducreyi</subject><subject>Haemophilus ducreyi - immunology</subject><subject>Humans</subject><subject>Hypersensitivity, Delayed</subject><subject>Immunity, Cellular</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inoculation</subject><subject>Kinetics</subject><subject>Lesions</subject><subject>Major Article</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Messenger RNA</subject><subject>RNA, Messenger - genetics</subject><subject>Skin - immunology</subject><subject>Skin - pathology</subject><subject>T lymphocytes</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - pathology</subject><subject>T-Lymphocytes - immunology</subject><subject>Time Factors</subject><subject>Transcription, Genetic</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV2L1DAUhoso67jqPxCCiHfVfLRpcymz63ZgxY8dYfEmJO2p07FNZvOxbH-G_9gsM8yANzmQ5-HlHN4se03wB4Jr_pGRoqjFk2xBSlblnBP2NFtgTGlOaiGeZy-832KMC8ars-xM1KSklCyyv-sNoNU0RQPoB_idNR5QsKhRMNndZhijR11sHczDI4dJj-CRQhcwqhm6fD3vADXpcR6MH8JwP4Q5maoNgzUobJyNvzc2BnT5kKRhAhPUiFamh71he9TESRl0E_U2_fmX2bNejR5eHeZ59vPz5XrZ5Ndfr1bLT9d5ywQOed0WmtGuL0jPmWZac14zrDvdUyWEqpSiglPSC2AdUVBzqFSnu1ZXFJd9jdl59n6fu3P2LoIPchp8C-OoDNjoZYVxWQomkvj2P3FrozNpN0kpEwQzQk5prbPeO-jlLh2r3CwJlo8FyX1BSXxzSIt6gu6oHRpJ_N2BK9-qsXfKtIM_pXFSlyU_xWx9sO6IGSaEFBVNPN_zwQd4OHLl_khesaqUze0veXNbLL99F1_kBfsHWjWyoQ</recordid><startdate>19981201</startdate><enddate>19981201</enddate><creator>Palmer, Katherine L.</creator><creator>Schnizlein-Bick, Carol T.</creator><creator>Orazi, Attilio</creator><creator>John, Karla</creator><creator>Chen, Cheng-Yen</creator><creator>Hood, Antoinette F.</creator><creator>Spinola, Stanley M.</creator><general>University Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19981201</creationdate><title>The Immune Response to Haemophilus ducreyi Resembles a Delayed-Type Hypersensitivity Reaction throughout Experimental Infection of Human Subjects</title><author>Palmer, Katherine L. ; Schnizlein-Bick, Carol T. ; Orazi, Attilio ; John, Karla ; Chen, Cheng-Yen ; Hood, Antoinette F. ; Spinola, Stanley M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-8c4b32df41f63b3bb66830bdbf2a99a7aa29621f9e3d1ae86e7adbdcb7205f803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Antibodies</topic><topic>Antibody Formation</topic><topic>Antigens, CD - analysis</topic><topic>B lymphocytes</topic><topic>B-Lymphocytes - immunology</topic><topic>Bacterial diseases</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biopsies</topic><topic>Biopsy</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - pathology</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - pathology</topic><topic>Chancroid - immunology</topic><topic>Chancroid - pathology</topic><topic>Cytokines</topic><topic>Cytokines - genetics</topic><topic>DNA Primers</topic><topic>DNA Probes</topic><topic>Experimental bacterial diseases and models</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Haemophilus ducreyi</topic><topic>Haemophilus ducreyi - immunology</topic><topic>Humans</topic><topic>Hypersensitivity, Delayed</topic><topic>Immunity, Cellular</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Inoculation</topic><topic>Kinetics</topic><topic>Lesions</topic><topic>Major Article</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Messenger RNA</topic><topic>RNA, Messenger - genetics</topic><topic>Skin - immunology</topic><topic>Skin - pathology</topic><topic>T lymphocytes</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - pathology</topic><topic>T-Lymphocytes - immunology</topic><topic>Time Factors</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palmer, Katherine L.</creatorcontrib><creatorcontrib>Schnizlein-Bick, Carol T.</creatorcontrib><creatorcontrib>Orazi, Attilio</creatorcontrib><creatorcontrib>John, Karla</creatorcontrib><creatorcontrib>Chen, Cheng-Yen</creatorcontrib><creatorcontrib>Hood, Antoinette F.</creatorcontrib><creatorcontrib>Spinola, Stanley M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palmer, Katherine L.</au><au>Schnizlein-Bick, Carol T.</au><au>Orazi, Attilio</au><au>John, Karla</au><au>Chen, Cheng-Yen</au><au>Hood, Antoinette F.</au><au>Spinola, Stanley M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Immune Response to Haemophilus ducreyi Resembles a Delayed-Type Hypersensitivity Reaction throughout Experimental Infection of Human Subjects</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>178</volume><issue>6</issue><spage>1688</spage><epage>1697</epage><pages>1688-1697</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Previous work in 3 subjects infected for 2 weeks indicated that experimental infection with Haemophilus ducreyi recruits CD4 cells to the skin at the pustular stage of disease. In order to describe the kinetics of the host response, 23 subjects were infected at 2 sites with a standardized dose of H ducreyi. Subjects were biopsied 1 or 4 days after inoculation or when they developed a painful pustular lesion (days 7–14). Papules and pustules contained a predominant T cell infiltrate that consisted of CD45RO and CD4 cells of the αβ lineage. Both papules and pustules contained mixed or T helper 1 type cytokine mRNA and interleukin-8 and tumor necrosis factor-α mRNA. Although the subjects had no history of chancroid, their immune responses resembled delayed-type hypersensitivity reactions that occurred within 24 h of inoculation and persisted throughout the course of experimental infection.</abstract><cop>Chicago, IL</cop><pub>University Chicago Press</pub><pmid>9815221</pmid><doi>10.1086/314489</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1998-12, Vol.178 (6), p.1688-1697 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70055939 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult AIDS/HIV Antibodies Antibody Formation Antigens, CD - analysis B lymphocytes B-Lymphocytes - immunology Bacterial diseases Base Sequence Biological and medical sciences Biopsies Biopsy CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Chancroid - immunology Chancroid - pathology Cytokines Cytokines - genetics DNA Primers DNA Probes Experimental bacterial diseases and models Female Gene Expression Regulation Haemophilus ducreyi Haemophilus ducreyi - immunology Humans Hypersensitivity, Delayed Immunity, Cellular Infections Infectious diseases Inoculation Kinetics Lesions Major Article Male Medical sciences Messenger RNA RNA, Messenger - genetics Skin - immunology Skin - pathology T lymphocytes T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - pathology T-Lymphocytes - immunology Time Factors Transcription, Genetic |
| title | The Immune Response to Haemophilus ducreyi Resembles a Delayed-Type Hypersensitivity Reaction throughout Experimental Infection of Human Subjects |
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