Response properties of neurons in the caudate–putamen and globus pallidus to noxious and non-noxious thermal stimulation in anesthetized rats
To investigate the possible mechanisms by which neurons in the caudate–putamen (CPu) and globus pallidus (GP) participate in pain and nociception, the present study characterized the response properties of CPu and GP neurons to non-noxious and noxious thermal stimuli in anesthetized rats. Nociceptiv...
Gespeichert in:
| Veröffentlicht in: | Brain research 1998-11, Vol.812 (1), p.283-288 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 288 |
|---|---|
| container_issue | 1 |
| container_start_page | 283 |
| container_title | Brain research |
| container_volume | 812 |
| creator | Chudler, Eric H |
| description | To investigate the possible mechanisms by which neurons in the caudate–putamen (CPu) and globus pallidus (GP) participate in pain and nociception, the present study characterized the response properties of CPu and GP neurons to non-noxious and noxious thermal stimuli in anesthetized rats. Nociceptive CPu and GP neurons were capable of encoding noxious thermal stimuli and 79% of these thermally responsive neurons also responded to noxious mechanical stimuli. Thermally responsive neurons were activated during the phasic rise and fall of the thermal shift in addition to the plateau temperature. The ability of CPu and GP neurons to encode noxious thermal stimulation intensity and respond during the dynamic phase of the stimulus suggests that these neurons may contribute to the behavioral response to minimize bodily harm. |
| doi_str_mv | 10.1016/S0006-8993(98)00971-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70055321</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006899398009718</els_id><sourcerecordid>17100212</sourcerecordid><originalsourceid>FETCH-LOGICAL-c538t-b1585358fd1804df817ae9d9ca3b936db846ac9822c407c4001c0cb64cd1822b3</originalsourceid><addsrcrecordid>eNqFUc1uFiEUJcamflYfoQkLY-xi9DLMD6yMaayaNGlSdU0YuKOYGRiBMerKN3DhG_ZJ5PuxLrsgcDnnnnvgEHLK4DkD1r14DwBdJaTkz6Q4A5A9q8Q9smGir6uubuA-2dxSHpCHKX0pJecSjsmxFIzzHjbk9zWmJfiEdIlhwZgdJhpG6nGN5Zo6T_NnpEavVme8-fVnWbOe0VPtLf00hWFNdNHT5Gw55EB9-O5COW5hH3z1ry4icdYTTdnN66SzC36rrT2mAmX3Ey2NOqdH5GjUU8LHh_2EfLx4_eH8bXV59ebd-avLyrRc5GpgrWh5K0bLBDR2FKzXKK00mg-Sd3YQTaeNFHVtGujLAmbADF1jSkNdD_yEPN3rlmd_XYsJNbtkcJqKo-JX9QBty2t2J5H1DKBmdSG2e6KJIaWIo1qim3X8oRiobWJql5jaxqGkULvElCh9p4cB6zCjve06RFTwJwdcJ6OnMWpvXPov3krW7Ma_3NOw_No3h1El49AbtC6iycoGd4eRv2mdtps</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17100212</pqid></control><display><type>article</type><title>Response properties of neurons in the caudate–putamen and globus pallidus to noxious and non-noxious thermal stimulation in anesthetized rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Chudler, Eric H</creator><creatorcontrib>Chudler, Eric H</creatorcontrib><description>To investigate the possible mechanisms by which neurons in the caudate–putamen (CPu) and globus pallidus (GP) participate in pain and nociception, the present study characterized the response properties of CPu and GP neurons to non-noxious and noxious thermal stimuli in anesthetized rats. Nociceptive CPu and GP neurons were capable of encoding noxious thermal stimuli and 79% of these thermally responsive neurons also responded to noxious mechanical stimuli. Thermally responsive neurons were activated during the phasic rise and fall of the thermal shift in addition to the plateau temperature. The ability of CPu and GP neurons to encode noxious thermal stimulation intensity and respond during the dynamic phase of the stimulus suggests that these neurons may contribute to the behavioral response to minimize bodily harm.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(98)00971-8</identifier><identifier>PMID: 9813370</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Anesthetics ; Animals ; Biological and medical sciences ; Caudate Nucleus - cytology ; Caudate Nucleus - physiology ; Caudate–putamen ; Electrophysiology ; Fundamental and applied biological sciences. Psychology ; Globus pallidus ; Globus Pallidus - cytology ; Globus Pallidus - physiology ; Hot Temperature - adverse effects ; Male ; Neurons - physiology ; Nociception ; Pain - physiopathology ; Putamen - cytology ; Putamen - physiology ; Rat ; Rats ; Rats, Sprague-Dawley ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Stress, Mechanical ; Thermal stimulation ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1998-11, Vol.812 (1), p.283-288</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1998 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-b1585358fd1804df817ae9d9ca3b936db846ac9822c407c4001c0cb64cd1822b3</citedby><cites>FETCH-LOGICAL-c538t-b1585358fd1804df817ae9d9ca3b936db846ac9822c407c4001c0cb64cd1822b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899398009718$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1591412$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9813370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chudler, Eric H</creatorcontrib><title>Response properties of neurons in the caudate–putamen and globus pallidus to noxious and non-noxious thermal stimulation in anesthetized rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>To investigate the possible mechanisms by which neurons in the caudate–putamen (CPu) and globus pallidus (GP) participate in pain and nociception, the present study characterized the response properties of CPu and GP neurons to non-noxious and noxious thermal stimuli in anesthetized rats. Nociceptive CPu and GP neurons were capable of encoding noxious thermal stimuli and 79% of these thermally responsive neurons also responded to noxious mechanical stimuli. Thermally responsive neurons were activated during the phasic rise and fall of the thermal shift in addition to the plateau temperature. The ability of CPu and GP neurons to encode noxious thermal stimulation intensity and respond during the dynamic phase of the stimulus suggests that these neurons may contribute to the behavioral response to minimize bodily harm.</description><subject>Anesthetics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Caudate Nucleus - cytology</subject><subject>Caudate Nucleus - physiology</subject><subject>Caudate–putamen</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Globus pallidus</subject><subject>Globus Pallidus - cytology</subject><subject>Globus Pallidus - physiology</subject><subject>Hot Temperature - adverse effects</subject><subject>Male</subject><subject>Neurons - physiology</subject><subject>Nociception</subject><subject>Pain - physiopathology</subject><subject>Putamen - cytology</subject><subject>Putamen - physiology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Stress, Mechanical</subject><subject>Thermal stimulation</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUc1uFiEUJcamflYfoQkLY-xi9DLMD6yMaayaNGlSdU0YuKOYGRiBMerKN3DhG_ZJ5PuxLrsgcDnnnnvgEHLK4DkD1r14DwBdJaTkz6Q4A5A9q8Q9smGir6uubuA-2dxSHpCHKX0pJecSjsmxFIzzHjbk9zWmJfiEdIlhwZgdJhpG6nGN5Zo6T_NnpEavVme8-fVnWbOe0VPtLf00hWFNdNHT5Gw55EB9-O5COW5hH3z1ry4icdYTTdnN66SzC36rrT2mAmX3Ey2NOqdH5GjUU8LHh_2EfLx4_eH8bXV59ebd-avLyrRc5GpgrWh5K0bLBDR2FKzXKK00mg-Sd3YQTaeNFHVtGujLAmbADF1jSkNdD_yEPN3rlmd_XYsJNbtkcJqKo-JX9QBty2t2J5H1DKBmdSG2e6KJIaWIo1qim3X8oRiobWJql5jaxqGkULvElCh9p4cB6zCjve06RFTwJwdcJ6OnMWpvXPov3krW7Ma_3NOw_No3h1El49AbtC6iycoGd4eRv2mdtps</recordid><startdate>19981123</startdate><enddate>19981123</enddate><creator>Chudler, Eric H</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19981123</creationdate><title>Response properties of neurons in the caudate–putamen and globus pallidus to noxious and non-noxious thermal stimulation in anesthetized rats</title><author>Chudler, Eric H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-b1585358fd1804df817ae9d9ca3b936db846ac9822c407c4001c0cb64cd1822b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anesthetics</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Caudate Nucleus - cytology</topic><topic>Caudate Nucleus - physiology</topic><topic>Caudate–putamen</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Globus pallidus</topic><topic>Globus Pallidus - cytology</topic><topic>Globus Pallidus - physiology</topic><topic>Hot Temperature - adverse effects</topic><topic>Male</topic><topic>Neurons - physiology</topic><topic>Nociception</topic><topic>Pain - physiopathology</topic><topic>Putamen - cytology</topic><topic>Putamen - physiology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Stress, Mechanical</topic><topic>Thermal stimulation</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chudler, Eric H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chudler, Eric H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response properties of neurons in the caudate–putamen and globus pallidus to noxious and non-noxious thermal stimulation in anesthetized rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1998-11-23</date><risdate>1998</risdate><volume>812</volume><issue>1</issue><spage>283</spage><epage>288</epage><pages>283-288</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>To investigate the possible mechanisms by which neurons in the caudate–putamen (CPu) and globus pallidus (GP) participate in pain and nociception, the present study characterized the response properties of CPu and GP neurons to non-noxious and noxious thermal stimuli in anesthetized rats. Nociceptive CPu and GP neurons were capable of encoding noxious thermal stimuli and 79% of these thermally responsive neurons also responded to noxious mechanical stimuli. Thermally responsive neurons were activated during the phasic rise and fall of the thermal shift in addition to the plateau temperature. The ability of CPu and GP neurons to encode noxious thermal stimulation intensity and respond during the dynamic phase of the stimulus suggests that these neurons may contribute to the behavioral response to minimize bodily harm.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>9813370</pmid><doi>10.1016/S0006-8993(98)00971-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1998-11, Vol.812 (1), p.283-288 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70055321 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anesthetics Animals Biological and medical sciences Caudate Nucleus - cytology Caudate Nucleus - physiology Caudate–putamen Electrophysiology Fundamental and applied biological sciences. Psychology Globus pallidus Globus Pallidus - cytology Globus Pallidus - physiology Hot Temperature - adverse effects Male Neurons - physiology Nociception Pain - physiopathology Putamen - cytology Putamen - physiology Rat Rats Rats, Sprague-Dawley Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Stress, Mechanical Thermal stimulation Vertebrates: nervous system and sense organs |
| title | Response properties of neurons in the caudate–putamen and globus pallidus to noxious and non-noxious thermal stimulation in anesthetized rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T11%3A05%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Response%20properties%20of%20neurons%20in%20the%20caudate%E2%80%93putamen%20and%20globus%20pallidus%20to%20noxious%20and%20non-noxious%20thermal%20stimulation%20in%20anesthetized%20rats&rft.jtitle=Brain%20research&rft.au=Chudler,%20Eric%20H&rft.date=1998-11-23&rft.volume=812&rft.issue=1&rft.spage=283&rft.epage=288&rft.pages=283-288&rft.issn=0006-8993&rft.eissn=1872-6240&rft.coden=BRREAP&rft_id=info:doi/10.1016/S0006-8993(98)00971-8&rft_dat=%3Cproquest_cross%3E17100212%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17100212&rft_id=info:pmid/9813370&rft_els_id=S0006899398009718&rfr_iscdi=true |