Decreased Helicobacter pylori- Specific Gastric Secretory IgA Antibodies in Infected Patients
Despite an increase in local Helicobacter pylori-specific IgA production in H. pylori infection, the bacterium is able to persist over decades. We focused on IgA and secretory IgA (sIgA) in gastric juice because sIgA is more relevant in local protection and more resistant to degradation than nonsecr...
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| Veröffentlicht in: | Digestion 1998-11, Vol.59 (6), p.638-645 |
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| creator | Birkholz, S. Schneider, T. Knipp, U. Stallmach, A. Zeitz, M. |
| description | Despite an increase in local Helicobacter pylori-specific IgA production in H. pylori infection, the bacterium is able to persist over decades. We focused on IgA and secretory IgA (sIgA) in gastric juice because sIgA is more relevant in local protection and more resistant to degradation than nonsecretory IgA. H. pylori-specific IgA and sIgA in gastric juice, saliva, and serum of H. pylori-infected patients were compared. Samples from 28 H. pylori-positive and 16 negative patients were tested by means of immunoblotting for the presence of H. pylori-specific IgA and sIgA. In gastric juice the majority of H. pylori-specific IgA was not of the secretory type, whereas total IgA was bound mainly to the secretory component as shown by immunoblot and slot blot. In contrast H. pylori-specific IgA antibodies in saliva of infected patients were of the secretory type as shown by immunoblot. The presence of specific, nonsecretory IgA may be a consequence of the damaged mucosal epithelium at the site of H. pylori infection allowing IgA to bypass the secretory transport system. Considering the resistance of secretory IgA against hydrolysis and proteolysis, these data suggest that the predominantly nonsecretory IgA specific for H. pylori may lead to a decreased protection against H. pylori. |
| doi_str_mv | 10.1159/000007568 |
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We focused on IgA and secretory IgA (sIgA) in gastric juice because sIgA is more relevant in local protection and more resistant to degradation than nonsecretory IgA. H. pylori-specific IgA and sIgA in gastric juice, saliva, and serum of H. pylori-infected patients were compared. Samples from 28 H. pylori-positive and 16 negative patients were tested by means of immunoblotting for the presence of H. pylori-specific IgA and sIgA. In gastric juice the majority of H. pylori-specific IgA was not of the secretory type, whereas total IgA was bound mainly to the secretory component as shown by immunoblot and slot blot. In contrast H. pylori-specific IgA antibodies in saliva of infected patients were of the secretory type as shown by immunoblot. The presence of specific, nonsecretory IgA may be a consequence of the damaged mucosal epithelium at the site of H. pylori infection allowing IgA to bypass the secretory transport system. Considering the resistance of secretory IgA against hydrolysis and proteolysis, these data suggest that the predominantly nonsecretory IgA specific for H. pylori may lead to a decreased protection against H. pylori.</description><identifier>ISSN: 0012-2823</identifier><identifier>EISSN: 1421-9867</identifier><identifier>DOI: 10.1159/000007568</identifier><identifier>PMID: 9813386</identifier><identifier>CODEN: DIGEBW</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Aged ; Antibodies, Bacterial - analysis ; Antibody Specificity ; Biological and medical sciences ; Cells, Cultured ; Enzyme-Linked Immunosorbent Assay ; Female ; Gastric Juice - immunology ; Gastric Mucosa - immunology ; Gastric Mucosa - microbiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Helicobacter ; Helicobacter Infections - immunology ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Helicobacter pylori - immunology ; Helicobacter pylori - isolation & purification ; Humans ; Immunoblotting ; Immunoglobulin A - analysis ; Immunoglobulin A, Secretory - analysis ; Male ; Medical sciences ; Middle Aged ; Original Paper ; Other diseases. Semiology ; Saliva - immunology ; Stomach Ulcer - immunology ; Stomach Ulcer - microbiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>Digestion, 1998-11, Vol.59 (6), p.638-645</ispartof><rights>1998 S. Karger AG, Basel</rights><rights>1999 INIST-CNRS</rights><rights>Copyright S. Karger AG Nov/Dec 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-1c29f5dba3bf81efdc262ff4cace4b898b973375e7902a5e0af2d13b227284a53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,2433,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1586189$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9813386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Birkholz, S.</creatorcontrib><creatorcontrib>Schneider, T.</creatorcontrib><creatorcontrib>Knipp, U.</creatorcontrib><creatorcontrib>Stallmach, A.</creatorcontrib><creatorcontrib>Zeitz, M.</creatorcontrib><title>Decreased Helicobacter pylori- Specific Gastric Secretory IgA Antibodies in Infected Patients</title><title>Digestion</title><addtitle>Digestion</addtitle><description>Despite an increase in local Helicobacter pylori-specific IgA production in H. pylori infection, the bacterium is able to persist over decades. We focused on IgA and secretory IgA (sIgA) in gastric juice because sIgA is more relevant in local protection and more resistant to degradation than nonsecretory IgA. H. pylori-specific IgA and sIgA in gastric juice, saliva, and serum of H. pylori-infected patients were compared. Samples from 28 H. pylori-positive and 16 negative patients were tested by means of immunoblotting for the presence of H. pylori-specific IgA and sIgA. In gastric juice the majority of H. pylori-specific IgA was not of the secretory type, whereas total IgA was bound mainly to the secretory component as shown by immunoblot and slot blot. In contrast H. pylori-specific IgA antibodies in saliva of infected patients were of the secretory type as shown by immunoblot. The presence of specific, nonsecretory IgA may be a consequence of the damaged mucosal epithelium at the site of H. pylori infection allowing IgA to bypass the secretory transport system. Considering the resistance of secretory IgA against hydrolysis and proteolysis, these data suggest that the predominantly nonsecretory IgA specific for H. pylori may lead to a decreased protection against H. pylori.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Bacterial - analysis</subject><subject>Antibody Specificity</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gastric Juice - immunology</subject><subject>Gastric Mucosa - immunology</subject><subject>Gastric Mucosa - microbiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Helicobacter</subject><subject>Helicobacter Infections - immunology</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - immunology</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Immunoglobulin A - analysis</subject><subject>Immunoglobulin A, Secretory - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Other diseases. Semiology</subject><subject>Saliva - immunology</subject><subject>Stomach Ulcer - immunology</subject><subject>Stomach Ulcer - microbiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Helicobacter</topic><topic>Helicobacter Infections - immunology</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - immunology</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Immunoglobulin A - analysis</topic><topic>Immunoglobulin A, Secretory - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Other diseases. Semiology</topic><topic>Saliva - immunology</topic><topic>Stomach Ulcer - immunology</topic><topic>Stomach Ulcer - microbiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Birkholz, S.</creatorcontrib><creatorcontrib>Schneider, T.</creatorcontrib><creatorcontrib>Knipp, U.</creatorcontrib><creatorcontrib>Stallmach, A.</creatorcontrib><creatorcontrib>Zeitz, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Digestion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Birkholz, S.</au><au>Schneider, T.</au><au>Knipp, U.</au><au>Stallmach, A.</au><au>Zeitz, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased Helicobacter pylori- Specific Gastric Secretory IgA Antibodies in Infected Patients</atitle><jtitle>Digestion</jtitle><addtitle>Digestion</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>59</volume><issue>6</issue><spage>638</spage><epage>645</epage><pages>638-645</pages><issn>0012-2823</issn><eissn>1421-9867</eissn><coden>DIGEBW</coden><abstract>Despite an increase in local Helicobacter pylori-specific IgA production in H. pylori infection, the bacterium is able to persist over decades. We focused on IgA and secretory IgA (sIgA) in gastric juice because sIgA is more relevant in local protection and more resistant to degradation than nonsecretory IgA. H. pylori-specific IgA and sIgA in gastric juice, saliva, and serum of H. pylori-infected patients were compared. Samples from 28 H. pylori-positive and 16 negative patients were tested by means of immunoblotting for the presence of H. pylori-specific IgA and sIgA. In gastric juice the majority of H. pylori-specific IgA was not of the secretory type, whereas total IgA was bound mainly to the secretory component as shown by immunoblot and slot blot. In contrast H. pylori-specific IgA antibodies in saliva of infected patients were of the secretory type as shown by immunoblot. The presence of specific, nonsecretory IgA may be a consequence of the damaged mucosal epithelium at the site of H. pylori infection allowing IgA to bypass the secretory transport system. Considering the resistance of secretory IgA against hydrolysis and proteolysis, these data suggest that the predominantly nonsecretory IgA specific for H. pylori may lead to a decreased protection against H. pylori.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>9813386</pmid><doi>10.1159/000007568</doi><tpages>8</tpages></addata></record> |
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| source | Karger e-journals Complete Collection; MEDLINE |
| subjects | Adult Aged Antibodies, Bacterial - analysis Antibody Specificity Biological and medical sciences Cells, Cultured Enzyme-Linked Immunosorbent Assay Female Gastric Juice - immunology Gastric Mucosa - immunology Gastric Mucosa - microbiology Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Helicobacter Infections - immunology Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - immunology Helicobacter pylori - isolation & purification Humans Immunoblotting Immunoglobulin A - analysis Immunoglobulin A, Secretory - analysis Male Medical sciences Middle Aged Original Paper Other diseases. Semiology Saliva - immunology Stomach Ulcer - immunology Stomach Ulcer - microbiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Decreased Helicobacter pylori- Specific Gastric Secretory IgA Antibodies in Infected Patients |
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