Systemic gabapentin and S(+)-3-isobutyl-γ-aminobutyric acid block secondary hyperalgesia

Gabapentin (GBP) and S(+)-3-isobutyl-γ-aminobutyric acid (IBG) are anticonvulsant agents which are effective against many clinical and experimental neuropathic pain states. We examined the efficacy of these agents in a new rat model of secondary mechanical hyperalgesia generated by a mild thermal in...

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Veröffentlicht in:	Brain research 1998-11, Vol.810 (1), p.93-99
Hauptverfasser:	Jones, Denise L., Sorkin, Linda S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - administration & dosage Acetates - pharmacology Allodynia Amines Animals Anticonvulsants - administration & dosage Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Burns - complications Cyclohexanecarboxylic Acids Dose-Response Relationship, Drug Gabapentin gamma-Aminobutyric Acid - administration & dosage gamma-Aminobutyric Acid - analogs & derivatives gamma-Aminobutyric Acid - pharmacology Hyperalgesia - etiology Hyperalgesia - prevention & control Injections, Intraperitoneal Male Medical sciences Neuropharmacology Pain Pain modulation Pain Threshold - drug effects Pharmacology Pharmacology. Drug treatments Pregabalin Rat Rats Rats, Sprague-Dawley Thermal injury
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