Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects

Background: Biotransformation of citalopram (CT), a newly available selective serotonin reuptake inhibitor antidepressant, to its principal metabolite, desmethycitalopram (DCT), and the capacity of CT and DCT to inhibit human cytochromes P450, were studied in vitro. Methods: Formation of DCT from CT...

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Veröffentlicht in:	Biological psychiatry (1969) 1999-09, Vol.46 (6), p.839-849
Hauptverfasser:	von Moltke, Lisa L., Greenblatt, David J., Grassi, Jeffrey M., Granda, Brian W., Venkatakrishnan, Karthik, Duan, Su Xiang, Fogelman, Steven M., Harmatz, Jerold S., Shader, Richard I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotransformation - physiology Cell Line, Transformed - drug effects Cells, Cultured Chromatography, High Pressure Liquid - methods Citalopram Citalopram - analogs & derivatives Citalopram - pharmacokinetics Cytochromes - metabolism cytochromes P450 DNA, Complementary - drug effects drug interactions drug metabolism Humans In Vitro Techniques Medical sciences Microsomes, Liver - metabolism Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology selective serotonin reuptake inhibitor Serotonin Uptake Inhibitors - pharmacokinetics Transfection - drug effects
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