Multiple Human Cytochromes Contribute to Biotransformation of Dextromethorphan In-vitro: Role of CYP2C9, CYP2C19, CYP2D6, and CYP3A

Cytochromes mediating the biotransformation of dextromethorphan to dextrorphan and 3‐methoxymorphinan, its principal metabolites in man, have been studied by use of liver microsomes and microsomes containing individual cytochromes expressed by cDNA‐transfected human lymphoblastoid cells. In‐vitro fo...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 1998-09, Vol.50 (9), p.997-1004
Hauptverfasser:	Von Moltke, Lisa L., Greenblatt, David J., Grassi, Jeffrey M., Granda, Brian W., Venkatakrishnan, Karthik, Schmider, JÜRgen, Harmatz, Jerold S., Shader, Richard I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - pharmacology Aryl Hydrocarbon Hydroxylases Biological and medical sciences Biotransformation Cytochrome P-450 CYP1A2 Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP2C9 Cytochrome P-450 CYP2D6 - physiology Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - physiology Dextromethorphan - analogs & derivatives Dextromethorphan - metabolism Dextromethorphan - pharmacokinetics Dextrorphan - metabolism Enzyme Inhibitors - pharmacology Excitatory Amino Acid Antagonists - pharmacokinetics General pharmacology Humans Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - metabolism Miscellaneous Mixed Function Oxygenases - physiology Oxidoreductases, N-Demethylating - physiology Pharmacology. Drug treatments Quinidine - pharmacology Steroid 16-alpha-Hydroxylase Steroid Hydroxylases - physiology Sulfaphenazole - pharmacology Transfection
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