A one-step solid phase immunoassay for simultaneous detection of serum IgG and IgM antibodies to Borrelia burgdorferi

A one-step immunoassay for simultaneous detection of serum IgG and IgM antibodies to Borrelia burgdorferi has been developed. The assay is based on C1q, which binds to immune complexes containing IgG and/or IgM antibodies. Micro-beads pre-coated with antibodies to human C1q are mixed with human seru...

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Veröffentlicht in:	Journal of immunological methods 1998-09, Vol.218 (1), p.9-17
Hauptverfasser:	Schønau, Andreas, Stender, Henrik, Grauballe, Per Chr
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bacterial - blood Antigen-Antibody Complex Antigens, Bacterial - immunology Bacterial diseases Biological and medical sciences Borrelia burgdorferi Borrelia infections C1q Complement C1q Enzyme-Linked Immunosorbent Assay - methods Flow cytometer Flow Cytometry Fluorescent Antibody Technique, Indirect Human bacterial diseases Humans Immunoassay - methods Immunoglobulin G - blood Immunoglobulin M - blood Infectious diseases Lyme Disease - blood Lyme Disease - epidemiology Medical sciences Micro-beads Multi-parameter screening One-step immunoassay Prevalence Prospective Studies Sensitivity and Specificity Tropical bacterial diseases
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