Associations of sex hormone concentrations with health and life satisfaction in elderly men
To analyze associations between sex hormone concentrations and self-rated health and life satisfaction, neuropsychiatric symptoms, or diagnosed depression or dementia in elderly men. The study subjects were men from the community-based Lieto Study (N = 517). Subjects were excluded from the study if...
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| Veröffentlicht in: | Endocrine practice 2007-11, Vol.13 (7), p.743-749 |
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| container_title | Endocrine practice |
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| creator | Eskelinen, Seija I Vahlberg, Tero J Isoaho, Raimo E Kivelä, Sirkka-Liisa Irjala, Kerttu M |
| description | To analyze associations between sex hormone concentrations and self-rated health and life satisfaction, neuropsychiatric symptoms, or diagnosed depression or dementia in elderly men.
The study subjects were men from the community-based Lieto Study (N = 517). Subjects were excluded from the study if they were taking exogenous sex hormones or medication for prostate cancer or for benign prostatic hyperplasia or if data for calculating body mass index (BMI) were missing. Thus, 466 men (64 to 97 years old; mean age, 72 years; mean BMI, 26.9 kg/m(2)) remained for further analysis.
After adjustment for age, higher levels of testosterone and free testosterone were associated with better self-rated health. After adjustment for age and BMI, no statistically significant associations were found between sex hormone levels and self-rated health or life satisfaction or most neuropsychiatric symptoms in elderly men. Diagnosed depression was associated with a lower serum testosterone concentration. Higher levels of luteinizing hormone and follicle-stimulating hormone were associated with diagnosed dementia.
In this population-based study with high attendance rate, low serum testosterone concentration was associated with diagnosed depression. Subclinical hypogonadism may be associated with diagnosed dementia. Single questions on neuropsychiatric symptoms commonly associated with androgen deficiency seemed to have weak or no correlation with testosterone or free testosterone levels among this group of elderly men. |
| doi_str_mv | 10.4158/EP.13.7.743 |
| format | Article |
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The study subjects were men from the community-based Lieto Study (N = 517). Subjects were excluded from the study if they were taking exogenous sex hormones or medication for prostate cancer or for benign prostatic hyperplasia or if data for calculating body mass index (BMI) were missing. Thus, 466 men (64 to 97 years old; mean age, 72 years; mean BMI, 26.9 kg/m(2)) remained for further analysis.
After adjustment for age, higher levels of testosterone and free testosterone were associated with better self-rated health. After adjustment for age and BMI, no statistically significant associations were found between sex hormone levels and self-rated health or life satisfaction or most neuropsychiatric symptoms in elderly men. Diagnosed depression was associated with a lower serum testosterone concentration. Higher levels of luteinizing hormone and follicle-stimulating hormone were associated with diagnosed dementia.
In this population-based study with high attendance rate, low serum testosterone concentration was associated with diagnosed depression. Subclinical hypogonadism may be associated with diagnosed dementia. Single questions on neuropsychiatric symptoms commonly associated with androgen deficiency seemed to have weak or no correlation with testosterone or free testosterone levels among this group of elderly men.</description><identifier>ISSN: 1530-891X</identifier><identifier>EISSN: 1934-2403</identifier><identifier>DOI: 10.4158/EP.13.7.743</identifier><identifier>PMID: 18194931</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Body Mass Index ; Body Weight ; Dementia - blood ; Estradiol - blood ; Follicle Stimulating Hormone - blood ; Gonadal Steroid Hormones - blood ; Health Status ; Humans ; Hypogonadism - blood ; Luteinizing Hormone - blood ; Male ; Middle Aged ; Personal Satisfaction ; Quality of Life ; Sex Hormone-Binding Globulin - analysis ; Testosterone - blood</subject><ispartof>Endocrine practice, 2007-11, Vol.13 (7), p.743-749</ispartof><rights>Copyright Allen Press Publishing Services Nov/Dec 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c230t-78320c513c7d9a8f8363c4a5cf77dcb6394006bb16c404d9173d2d37c16e08cf3</citedby><cites>FETCH-LOGICAL-c230t-78320c513c7d9a8f8363c4a5cf77dcb6394006bb16c404d9173d2d37c16e08cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1697013938?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,64374,64376,64378,72230</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18194931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eskelinen, Seija I</creatorcontrib><creatorcontrib>Vahlberg, Tero J</creatorcontrib><creatorcontrib>Isoaho, Raimo E</creatorcontrib><creatorcontrib>Kivelä, Sirkka-Liisa</creatorcontrib><creatorcontrib>Irjala, Kerttu M</creatorcontrib><title>Associations of sex hormone concentrations with health and life satisfaction in elderly men</title><title>Endocrine practice</title><addtitle>Endocr Pract</addtitle><description>To analyze associations between sex hormone concentrations and self-rated health and life satisfaction, neuropsychiatric symptoms, or diagnosed depression or dementia in elderly men.
The study subjects were men from the community-based Lieto Study (N = 517). Subjects were excluded from the study if they were taking exogenous sex hormones or medication for prostate cancer or for benign prostatic hyperplasia or if data for calculating body mass index (BMI) were missing. Thus, 466 men (64 to 97 years old; mean age, 72 years; mean BMI, 26.9 kg/m(2)) remained for further analysis.
After adjustment for age, higher levels of testosterone and free testosterone were associated with better self-rated health. After adjustment for age and BMI, no statistically significant associations were found between sex hormone levels and self-rated health or life satisfaction or most neuropsychiatric symptoms in elderly men. Diagnosed depression was associated with a lower serum testosterone concentration. Higher levels of luteinizing hormone and follicle-stimulating hormone were associated with diagnosed dementia.
In this population-based study with high attendance rate, low serum testosterone concentration was associated with diagnosed depression. Subclinical hypogonadism may be associated with diagnosed dementia. Single questions on neuropsychiatric symptoms commonly associated with androgen deficiency seemed to have weak or no correlation with testosterone or free testosterone levels among this group of elderly men.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Dementia - blood</subject><subject>Estradiol - blood</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>Health Status</subject><subject>Humans</subject><subject>Hypogonadism - blood</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Personal Satisfaction</subject><subject>Quality of Life</subject><subject>Sex Hormone-Binding Globulin - analysis</subject><subject>Testosterone - blood</subject><issn>1530-891X</issn><issn>1934-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkEtLxDAUhYMozvhYuZeA4EY65vamTbIcZHyAoAsFwUVI05SptMmYdFD_vRULgqtz4XwcLh8hJ8AWHAp5uXpcAC7EQnDcIXNQyLOcM9wd7wJZJhW8zMhBSm-M5UyB3CczkKC4QpiT12VKwbZmaINPNDQ0uU-6DrEP3lEbvHV-iFP70Q5runamG8P4mnZt42gay9QY-4PQ1lPX1S52X7R3_ojsNaZL7njKQ_J8vXq6us3uH27urpb3mc2RDZmQmDNbAFpRKyMbiSVabgrbCFHbqkTFGSurCkrLGa8VCKzzGoWF0jFpGzwk57-7mxjety4Num-TdV1nvAvbpAVjBeRYjODZP_AtbKMff9NQKsEAFcqRuvilbAwpRdfoTWx7E780MP1jXK8eNaAWejQ-0qfT5rbqXf3HTorxG584e1U</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Eskelinen, Seija I</creator><creator>Vahlberg, Tero J</creator><creator>Isoaho, Raimo E</creator><creator>Kivelä, Sirkka-Liisa</creator><creator>Irjala, Kerttu M</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200711</creationdate><title>Associations of sex hormone concentrations with health and life satisfaction in elderly men</title><author>Eskelinen, Seija I ; Vahlberg, Tero J ; Isoaho, Raimo E ; Kivelä, Sirkka-Liisa ; Irjala, Kerttu M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c230t-78320c513c7d9a8f8363c4a5cf77dcb6394006bb16c404d9173d2d37c16e08cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Dementia - blood</topic><topic>Estradiol - blood</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>Health Status</topic><topic>Humans</topic><topic>Hypogonadism - blood</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Personal Satisfaction</topic><topic>Quality of Life</topic><topic>Sex Hormone-Binding Globulin - analysis</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eskelinen, Seija I</creatorcontrib><creatorcontrib>Vahlberg, Tero J</creatorcontrib><creatorcontrib>Isoaho, Raimo E</creatorcontrib><creatorcontrib>Kivelä, Sirkka-Liisa</creatorcontrib><creatorcontrib>Irjala, Kerttu M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Health Management</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eskelinen, Seija I</au><au>Vahlberg, Tero J</au><au>Isoaho, Raimo E</au><au>Kivelä, Sirkka-Liisa</au><au>Irjala, Kerttu M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of sex hormone concentrations with health and life satisfaction in elderly men</atitle><jtitle>Endocrine practice</jtitle><addtitle>Endocr Pract</addtitle><date>2007-11</date><risdate>2007</risdate><volume>13</volume><issue>7</issue><spage>743</spage><epage>749</epage><pages>743-749</pages><issn>1530-891X</issn><eissn>1934-2403</eissn><abstract>To analyze associations between sex hormone concentrations and self-rated health and life satisfaction, neuropsychiatric symptoms, or diagnosed depression or dementia in elderly men.
The study subjects were men from the community-based Lieto Study (N = 517). Subjects were excluded from the study if they were taking exogenous sex hormones or medication for prostate cancer or for benign prostatic hyperplasia or if data for calculating body mass index (BMI) were missing. Thus, 466 men (64 to 97 years old; mean age, 72 years; mean BMI, 26.9 kg/m(2)) remained for further analysis.
After adjustment for age, higher levels of testosterone and free testosterone were associated with better self-rated health. After adjustment for age and BMI, no statistically significant associations were found between sex hormone levels and self-rated health or life satisfaction or most neuropsychiatric symptoms in elderly men. Diagnosed depression was associated with a lower serum testosterone concentration. Higher levels of luteinizing hormone and follicle-stimulating hormone were associated with diagnosed dementia.
In this population-based study with high attendance rate, low serum testosterone concentration was associated with diagnosed depression. Subclinical hypogonadism may be associated with diagnosed dementia. Single questions on neuropsychiatric symptoms commonly associated with androgen deficiency seemed to have weak or no correlation with testosterone or free testosterone levels among this group of elderly men.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>18194931</pmid><doi>10.4158/EP.13.7.743</doi><tpages>7</tpages></addata></record> |
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| ispartof | Endocrine practice, 2007-11, Vol.13 (7), p.743-749 |
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| subjects | Aged Aged, 80 and over Aging Body Mass Index Body Weight Dementia - blood Estradiol - blood Follicle Stimulating Hormone - blood Gonadal Steroid Hormones - blood Health Status Humans Hypogonadism - blood Luteinizing Hormone - blood Male Middle Aged Personal Satisfaction Quality of Life Sex Hormone-Binding Globulin - analysis Testosterone - blood |
| title | Associations of sex hormone concentrations with health and life satisfaction in elderly men |
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