A novel antineuronal antibody in a motor neuron syndrome associated with breast cancer
A 72-year-old woman developed a lower motor neuron syndrome (MNS) 4 months before the appearance of breast cancer. Monoparesis progressed to quadriparesis despite high-dose IV immunoglobulins, plasma exchange, and azathioprine, and high-dose IV methylprednisolone. The patient improved only after the...
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| Veröffentlicht in: | Neurology 1999-09, Vol.53 (4), p.852-855 |
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| container_title | Neurology |
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| creator | FERRACCI, F FASSETTA, G BUTLER, M. H FLOYD, S SOLIMENA, M DE CAMILLI, P |
| description | A 72-year-old woman developed a lower motor neuron syndrome (MNS) 4 months before the appearance of breast cancer. Monoparesis progressed to quadriparesis despite high-dose IV immunoglobulins, plasma exchange, and azathioprine, and high-dose IV methylprednisolone. The patient improved only after the removal of the tumor. MRI demonstrated hyperintensities in the cervical spinal cord. The patient had antibodies that reacted with axonal initial segments and nodes of Ranvier. The findings suggest that in this patient lower MNS may be a paraneoplastic condition associated with breast cancer. |
| doi_str_mv | 10.1212/wnl.53.4.852 |
| format | Article |
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The findings suggest that in this patient lower MNS may be a paraneoplastic condition associated with breast cancer.</description><subject>Aged</subject><subject>Autoantibodies - immunology</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - immunology</subject><subject>Breast Neoplasms - pathology</subject><subject>Electromyography</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Motor Neuron Disease - complications</subject><subject>Motor Neuron Disease - immunology</subject><subject>Neurology</subject><subject>Tumors</subject><subject>Tumors of the nervous system. 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Obstetrics</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Motor Neuron Disease - complications</topic><topic>Motor Neuron Disease - immunology</topic><topic>Neurology</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FERRACCI, F</creatorcontrib><creatorcontrib>FASSETTA, G</creatorcontrib><creatorcontrib>BUTLER, M. 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H</au><au>FLOYD, S</au><au>SOLIMENA, M</au><au>DE CAMILLI, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel antineuronal antibody in a motor neuron syndrome associated with breast cancer</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>1999-09-11</date><risdate>1999</risdate><volume>53</volume><issue>4</issue><spage>852</spage><epage>855</epage><pages>852-855</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>A 72-year-old woman developed a lower motor neuron syndrome (MNS) 4 months before the appearance of breast cancer. Monoparesis progressed to quadriparesis despite high-dose IV immunoglobulins, plasma exchange, and azathioprine, and high-dose IV methylprednisolone. The patient improved only after the removal of the tumor. MRI demonstrated hyperintensities in the cervical spinal cord. The patient had antibodies that reacted with axonal initial segments and nodes of Ranvier. 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| fulltext | fulltext |
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| ispartof | Neurology, 1999-09, Vol.53 (4), p.852-855 |
| issn | 0028-3878 1526-632X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Aged Autoantibodies - immunology Biological and medical sciences Blotting, Western Breast Neoplasms - complications Breast Neoplasms - immunology Breast Neoplasms - pathology Electromyography Female Fluorescent Antibody Technique Gynecology. Andrology. Obstetrics Humans Magnetic Resonance Imaging Mammary gland diseases Medical sciences Motor Neuron Disease - complications Motor Neuron Disease - immunology Neurology Tumors Tumors of the nervous system. Phacomatoses |
| title | A novel antineuronal antibody in a motor neuron syndrome associated with breast cancer |
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