Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

AKT2 is a serine/threonine kinase implicated in human ovarian and pancreatic cancers. AKT2 is activated by a variety of growth factors and insulin via phosphatidylinositol 3-kinase (PI3K). However, its normal cellular role is not well understood. To gain insight into the function of AKT2, we perform...

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Veröffentlicht in:	Oncogene 1999-09, Vol.18 (35), p.4891-4898
Hauptverfasser:	MITSUUCHI, Y, JOHNSON, S. W, SONODA, G, TANNO, S, GOLEMIS, E. A, TESTA, J. R
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adaptor proteins AKT2 protein Amino Acid Sequence Apoptosis APPL gene Binding Sites Biological and medical sciences Cardiac muscle Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cell membranes Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome 3 Chromosomes, Human, Pair 3 - genetics Cloning, Molecular Cytoplasm Enzyme Activation Female Fundamental and applied biological sciences. Psychology Glucose transporter GLUT2 protein Growth factors Homology Humans Insulin Kinases Leucine zipper proteins Leucine Zippers Molecular and cellular biology Molecular Sequence Data mRNA Oncoproteins Ovarian Neoplasms Pancreatic cancer Phosphatidylinositol 3-Kinases - chemistry Phosphatidylinositol 3-Kinases - metabolism Phosphotyrosine Phosphotyrosine - metabolism Physical Chromosome Mapping Pleckstrin Precipitin Tests Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-serine/threonine kinase Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt RNA, Messenger - analysis RNA, Messenger - genetics Sequence Homology, Amino Acid Signal Transduction Skeletal muscle Tumor Cells, Cultured Tumors Yeasts - genetics Yeasts - metabolism
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