Troponin T Levels and Abciximab Therapy in Unstable Angina
To the Editor: The accuracy of measurements of troponin T and creatine kinase MB fraction (CK-MB) is central to the results of the c7E3 Fab Antiplatelet Therapy in Unstable Angina (CAPTURE) study reported by Hamm et al. (May 27 issue). 1 The authors state that “all serum samples were stored at –20°C...
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| Veröffentlicht in: | The New England journal of medicine 1999-09, Vol.341 (14), p.1084-1085 |
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| container_issue | 14 |
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| container_title | The New England journal of medicine |
| container_volume | 341 |
| creator | Lev, Eli I Osende, Julio I Zaman, Azfar G Hamm, Christian W Heeschen, Christopher |
| description | To the Editor:
The accuracy of measurements of troponin T and creatine kinase MB fraction (CK-MB) is central to the results of the c7E3 Fab Antiplatelet Therapy in Unstable Angina (CAPTURE) study reported by Hamm et al. (May 27 issue).
1
The authors state that “all serum samples were stored at –20°C or lower and transported to a central laboratory, where they were stored at –80°C until they were analyzed.”
It is recognized that total creatine kinase activity decreases steadily when stored at a temperature of –30°C (there is a decline in activity of 8.3 percent after four weeks).
2
A similar . . . |
| doi_str_mv | 10.1056/NEJM199909303411416 |
| format | Article |
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The accuracy of measurements of troponin T and creatine kinase MB fraction (CK-MB) is central to the results of the c7E3 Fab Antiplatelet Therapy in Unstable Angina (CAPTURE) study reported by Hamm et al. (May 27 issue).
1
The authors state that “all serum samples were stored at –20°C or lower and transported to a central laboratory, where they were stored at –80°C until they were analyzed.”
It is recognized that total creatine kinase activity decreases steadily when stored at a temperature of –30°C (there is a decline in activity of 8.3 percent after four weeks).
2
A similar . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199909303411416</identifier><identifier>PMID: 10507932</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Blood Preservation - methods ; Creatine Kinase - blood ; Cryopreservation ; Humans ; Isoenzymes ; Specimen Handling ; Troponin T - blood</subject><ispartof>The New England journal of medicine, 1999-09, Vol.341 (14), p.1084-1085</ispartof><rights>Copyright © 1999 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-3175aac8d8cca78dea7d624c731775e88042d28a42827de970c82e54193fcf1d3</citedby><cites>FETCH-LOGICAL-c403t-3175aac8d8cca78dea7d624c731775e88042d28a42827de970c82e54193fcf1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199909303411416$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199909303411416$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10507932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lev, Eli I</creatorcontrib><creatorcontrib>Osende, Julio I</creatorcontrib><creatorcontrib>Zaman, Azfar G</creatorcontrib><creatorcontrib>Hamm, Christian W</creatorcontrib><creatorcontrib>Heeschen, Christopher</creatorcontrib><title>Troponin T Levels and Abciximab Therapy in Unstable Angina</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
The accuracy of measurements of troponin T and creatine kinase MB fraction (CK-MB) is central to the results of the c7E3 Fab Antiplatelet Therapy in Unstable Angina (CAPTURE) study reported by Hamm et al. (May 27 issue).
1
The authors state that “all serum samples were stored at –20°C or lower and transported to a central laboratory, where they were stored at –80°C until they were analyzed.”
It is recognized that total creatine kinase activity decreases steadily when stored at a temperature of –30°C (there is a decline in activity of 8.3 percent after four weeks).
2
A similar . . .</description><subject>Blood Preservation - methods</subject><subject>Creatine Kinase - blood</subject><subject>Cryopreservation</subject><subject>Humans</subject><subject>Isoenzymes</subject><subject>Specimen Handling</subject><subject>Troponin T - blood</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwBUgoYsEGBfxKbLOrqvJSgU26thzbgVSJU-wG0b_HKF0ghJjNSDPnXs1cAE4RvEIwy6-f549PSAgBBYGEIkRRvgfGKCMkpRTm-2AMIeYpZYKMwFEIKxgLUXEIRlEP4xiPwU3hu3XnapcUycJ-2CYkyplkWur6s25VmRRv1qv1NonE0oWNKhubTN1r7dQxOKhUE-zJrk_A8nZezO7Txcvdw2y6SDWFZJMSxDKlNDdca8W4sYqZHFPN4oJllnNIscFcUcwxM1YwqDm2GUWCVLpChkzAxeC79t17b8NGtnXQtmmUs10fJIOQCsZhBM9_gauu9y7eJjEmgjKMWITIAGnfheBtJdc-Puq3EkH5nav8I9eoOttZ92VrzQ_NEGQELgegbYN0dtX-a_cFbst8kQ</recordid><startdate>19990930</startdate><enddate>19990930</enddate><creator>Lev, Eli I</creator><creator>Osende, Julio I</creator><creator>Zaman, Azfar G</creator><creator>Hamm, Christian W</creator><creator>Heeschen, Christopher</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19990930</creationdate><title>Troponin T Levels and Abciximab Therapy in Unstable Angina</title><author>Lev, Eli I ; Osende, Julio I ; Zaman, Azfar G ; Hamm, Christian W ; Heeschen, Christopher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-3175aac8d8cca78dea7d624c731775e88042d28a42827de970c82e54193fcf1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Blood Preservation - methods</topic><topic>Creatine Kinase - blood</topic><topic>Cryopreservation</topic><topic>Humans</topic><topic>Isoenzymes</topic><topic>Specimen Handling</topic><topic>Troponin T - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lev, Eli I</creatorcontrib><creatorcontrib>Osende, Julio I</creatorcontrib><creatorcontrib>Zaman, Azfar G</creatorcontrib><creatorcontrib>Hamm, Christian W</creatorcontrib><creatorcontrib>Heeschen, Christopher</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lev, Eli I</au><au>Osende, Julio I</au><au>Zaman, Azfar G</au><au>Hamm, Christian W</au><au>Heeschen, Christopher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Troponin T Levels and Abciximab Therapy in Unstable Angina</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1999-09-30</date><risdate>1999</risdate><volume>341</volume><issue>14</issue><spage>1084</spage><epage>1085</epage><pages>1084-1085</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>To the Editor:
The accuracy of measurements of troponin T and creatine kinase MB fraction (CK-MB) is central to the results of the c7E3 Fab Antiplatelet Therapy in Unstable Angina (CAPTURE) study reported by Hamm et al. (May 27 issue).
1
The authors state that “all serum samples were stored at –20°C or lower and transported to a central laboratory, where they were stored at –80°C until they were analyzed.”
It is recognized that total creatine kinase activity decreases steadily when stored at a temperature of –30°C (there is a decline in activity of 8.3 percent after four weeks).
2
A similar . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>10507932</pmid><doi>10.1056/NEJM199909303411416</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1999-09, Vol.341 (14), p.1084-1085 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Blood Preservation - methods Creatine Kinase - blood Cryopreservation Humans Isoenzymes Specimen Handling Troponin T - blood |
| title | Troponin T Levels and Abciximab Therapy in Unstable Angina |
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