Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils

Leukocyte chemoattractants are known to stimulate signaling pathways that involve Rho family GTPases. Direct evidence for the regulation of the leukocyte cytoskeleton by Rho GTPases and their effector targets is limited. The p21‐activated kinases (PAKs) are specific targets of activated GTP‐bound Ra...

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Veröffentlicht in:	Journal of leukocyte biology 1999-09, Vol.66 (3), p.521-527
Hauptverfasser:	Dharmawardhane, Suranganie, Brownson, Delia, Lennartz, Michelle, Bokoch, Gary M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - ultrastructure Adult Androstadienes - pharmacology cdc42 GTP-Binding Protein Cell Cycle Proteins - physiology Cell Polarity Chemotaxis, Leukocyte - drug effects Complement C3b - physiology Cytochalasin D - pharmacology cytoskeleton Cytoskeleton - chemistry Cytoskeleton - drug effects Cytoskeleton - ultrastructure Enzyme Inhibitors - pharmacology GTP-Binding Proteins - physiology Humans leukocytes Microscopy, Confocal Microscopy, Fluorescence N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - drug effects Neutrophils - enzymology Neutrophils - ultrastructure Opsonin Proteins - pharmacology p21-Activated Kinases phagocytosis Phagocytosis - drug effects Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology Protein-Serine-Threonine Kinases - analysis Protein-Serine-Threonine Kinases - physiology Pseudopodia - enzymology rac GTP-Binding Proteins Rho GTPases Wortmannin Zymosan - pharmacology
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