Dysregulated cyclin D1 expression early in head and neck tumorigenesis : in vivo evidence for an association with subsequent gene amplification

Cyclin D1 proto-oncogene is a key regulator of the mammalian cell-cycle acting at the restriction point in late G1. Amplification of the cyclin D1 locus, located on chromosome 11q13, as well as cyclin D1 protein overexpression have been reported in several human malignancies. The purpose of this stu...

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Veröffentlicht in:	Oncogene 1998-11, Vol.17 (18), p.2313-2322
Hauptverfasser:	IZZO, J. G, PAPADIMITRAKOPOULOU, V. A, LI, X. Q, IBARGUEN, H, LEE, J. S, RO, J. Y, EL-NAGGAR, A, HONG, W. K, HITTELMAN, W. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome 11 Cyclin D1 Cyclin D1 - genetics Cyclin D1 - metabolism D1 protein Fibroblast Growth Factor 3 Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism Fluorescence in situ hybridization Fundamental and applied biological sciences. Psychology Gene Amplification Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humans Immunohistochemistry In Situ Hybridization, Fluorescence Invasiveness Lesions Molecular and cellular biology Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Paraffin Precancerous Conditions - genetics Precancerous Conditions - metabolism Precancerous Conditions - pathology Protein expression Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Tumorigenesis Tumors
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