The role of microsomal triglyceride transfer protein and dietary cholesterol in chylomicron production in diabetes

The aim of this study was to examine factors involved in chylomicron production in the streptozotocin diabetic rat, our hypothesis being that the synthesis of the chylomicron is abnormal in diabetes. Diabetic rats (n = 20) were paired with control rats (n = 20). Cholesterol emulsion was given by gav...

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Veröffentlicht in:	Diabetologia 1999-08, Vol.42 (8), p.944-948
Hauptverfasser:	GLEESON, A, ANDERTON, K, OWENS, D, BENNETT, A, COLLINS, P, JOHNSON, A, WHITE, D, TOMKIN, G. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein B-48 Apolipoproteins Apolipoproteins B - genetics Apolipoproteins B - metabolism Biochemistry Biological and medical sciences Carrier Proteins - metabolism Cholesterol Cholesterol - blood Cholesterol, Dietary - metabolism Cholesterol, Dietary - pharmacology Chylomicrons - biosynthesis Chylomicrons - genetics Diabetes Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Diet Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Gene Expression Regulation Glucose Hypotheses Insulin Intestinal Mucosa - metabolism Laboratory animals Lipoproteins - blood Lipoproteins - metabolism Lymph - metabolism Male Medical sciences Microsomes - metabolism Proteins Rats Rats, Sprague-Dawley Reference Values RNA, Messenger - genetics RNA, Messenger - metabolism Triglycerides - blood
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