Does the membrane's physical state control the expression of heat shock and other genes?
Membranes provide the structural framework that divides cells from their environment and that, in eukaryotic cells, permits compartmentation. They are not simply passive barriers that are liable to be damaged during environmental challenge or pathological states, but are involved in cellular respons...
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| Veröffentlicht in: | Trends in biochemical sciences (Amsterdam. Regular ed.) 1998-10, Vol.23 (10), p.369-374 |
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| container_end_page | 374 |
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| container_title | Trends in biochemical sciences (Amsterdam. Regular ed.) |
| container_volume | 23 |
| creator | Vigh, Laszlo Maresca, Bruno Harwood, John L. |
| description | Membranes provide the structural framework that divides cells from their environment and that, in eukaryotic cells, permits compartmentation. They are not simply passive barriers that are liable to be damaged during environmental challenge or pathological states, but are involved in cellular responses and in modulating intracellular signalling. Recent data show that the expression of several genes, particularly those that respond to changes in temperature, ageing or disease, is influenced and/or controlled by the membrane's physical state. |
| doi_str_mv | 10.1016/S0968-0004(98)01279-1 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0968-0004 |
| ispartof | Trends in biochemical sciences (Amsterdam. Regular ed.), 1998-10, Vol.23 (10), p.369-374 |
| issn | 0968-0004 1362-4326 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect |
| subjects | Animals fatty acid desaturases Gene Expression Regulation gene induction heat-shock proteins Heat-Shock Proteins - genetics Humans Membrane Fluidity Membrane Lipids - chemistry Membrane Lipids - metabolism membrane physical state Membrane Proteins - genetics Membranes - chemistry Membranes - metabolism Temperature |
| title | Does the membrane's physical state control the expression of heat shock and other genes? |
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