Inescapable Shock-Induced Potentiation of Morphine Analgesia in Rats: Sites of Action

Inescapable shock (IS) enhances analgesia to systemic morphine (MOR) 24 hr later. IS activates serotonin neurons in the dorsal raphe nucleus (DRN), rendering them hyperexcitable. These studies tested whether IS potentiates the analgesic effect of MOR microinjected in the DRN, as predicted by this hy...

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Veröffentlicht in:	Behavioral neuroscience 1999-08, Vol.113 (4), p.795-803
Hauptverfasser:	Hammack, Sayamwong E, Hartley, Chad E, Lea, S. Elizabeth, Maier, Steven F, Watkins, Linda R, Sutton, Lorraine C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics Analgesics, Opioid - pharmacology Anatomical correlates of behavior Animal Animals Behavioral psychophysiology Biological and medical sciences Electroshock Fundamental and applied biological sciences. Psychology Male Morphine Morphine - pharmacology Neurology Pain Threshold - drug effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Raphe Nuclei Raphe Nuclei - drug effects Rats Rats, Sprague-Dawley Rodents Serotonin - metabolism Shock Spinal Cord Spinal Cord - drug effects
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