Inescapable Shock-Induced Potentiation of Morphine Analgesia in Rats: Sites of Action
Inescapable shock (IS) enhances analgesia to systemic morphine (MOR) 24 hr later. IS activates serotonin neurons in the dorsal raphe nucleus (DRN), rendering them hyperexcitable. These studies tested whether IS potentiates the analgesic effect of MOR microinjected in the DRN, as predicted by this hy...
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| Veröffentlicht in: | Behavioral neuroscience 1999-08, Vol.113 (4), p.795-803 |
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| creator | Hammack, Sayamwong E Hartley, Chad E Lea, S. Elizabeth Maier, Steven F Watkins, Linda R Sutton, Lorraine C |
| description | Inescapable shock (IS) enhances analgesia to systemic
morphine (MOR) 24 hr later. IS activates serotonin neurons in the
dorsal raphe nucleus (DRN), rendering them hyperexcitable. These
studies tested whether IS potentiates the analgesic effect of MOR
microinjected in the DRN, as predicted by this hypothesis. To test
site specificity, the effect of previous IS was examined on MOR
microinjected lateral to the DRN and into 2 other sites that support
MOR analgesia, the nucleus raphe magnus (NRM) and spinal cord.
Twenty-four hours after IS, potentiated analgesia was observed after
0.5 μg MOR microinjected into, but not lateral to, the DRN.
Potentiated analgesia was also observed after NRM (1.0 μg) and
spinal cord (3.0 μg) MOR microinjections. These data suggest
that IS-induced excitability changes within the DRN synergize with
opiates microinjected in other analgesia areas and that this
potentiates the responses to opiates 24 hr after IS. |
| doi_str_mv | 10.1037/0735-7044.113.4.795 |
| format | Article |
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morphine (MOR) 24 hr later. IS activates serotonin neurons in the
dorsal raphe nucleus (DRN), rendering them hyperexcitable. These
studies tested whether IS potentiates the analgesic effect of MOR
microinjected in the DRN, as predicted by this hypothesis. To test
site specificity, the effect of previous IS was examined on MOR
microinjected lateral to the DRN and into 2 other sites that support
MOR analgesia, the nucleus raphe magnus (NRM) and spinal cord.
Twenty-four hours after IS, potentiated analgesia was observed after
0.5 μg MOR microinjected into, but not lateral to, the DRN.
Potentiated analgesia was also observed after NRM (1.0 μg) and
spinal cord (3.0 μg) MOR microinjections. These data suggest
that IS-induced excitability changes within the DRN synergize with
opiates microinjected in other analgesia areas and that this
potentiates the responses to opiates 24 hr after IS.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.113.4.795</identifier><identifier>PMID: 10495087</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Analgesia ; Analgesics ; Analgesics, Opioid - pharmacology ; Anatomical correlates of behavior ; Animal ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Electroshock ; Fundamental and applied biological sciences. Psychology ; Male ; Morphine ; Morphine - pharmacology ; Neurology ; Pain Threshold - drug effects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Raphe Nuclei ; Raphe Nuclei - drug effects ; Rats ; Rats, Sprague-Dawley ; Rodents ; Serotonin - metabolism ; Shock ; Spinal Cord ; Spinal Cord - drug effects</subject><ispartof>Behavioral neuroscience, 1999-08, Vol.113 (4), p.795-803</ispartof><rights>1999 American Psychological Association</rights><rights>1999 INIST-CNRS</rights><rights>Copyright American Psychological Association Aug 1999</rights><rights>1999, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a414t-407e0271a0090c768300f3d2306169bb9f731c2f4d4e824d1f36d30b176235453</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1923163$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10495087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hammack, Sayamwong E</creatorcontrib><creatorcontrib>Hartley, Chad E</creatorcontrib><creatorcontrib>Lea, S. Elizabeth</creatorcontrib><creatorcontrib>Maier, Steven F</creatorcontrib><creatorcontrib>Watkins, Linda R</creatorcontrib><creatorcontrib>Sutton, Lorraine C</creatorcontrib><title>Inescapable Shock-Induced Potentiation of Morphine Analgesia in Rats: Sites of Action</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Inescapable shock (IS) enhances analgesia to systemic
morphine (MOR) 24 hr later. IS activates serotonin neurons in the
dorsal raphe nucleus (DRN), rendering them hyperexcitable. These
studies tested whether IS potentiates the analgesic effect of MOR
microinjected in the DRN, as predicted by this hypothesis. To test
site specificity, the effect of previous IS was examined on MOR
microinjected lateral to the DRN and into 2 other sites that support
MOR analgesia, the nucleus raphe magnus (NRM) and spinal cord.
Twenty-four hours after IS, potentiated analgesia was observed after
0.5 μg MOR microinjected into, but not lateral to, the DRN.
Potentiated analgesia was also observed after NRM (1.0 μg) and
spinal cord (3.0 μg) MOR microinjections. These data suggest
that IS-induced excitability changes within the DRN synergize with
opiates microinjected in other analgesia areas and that this
potentiates the responses to opiates 24 hr after IS.</description><subject>Analgesia</subject><subject>Analgesics</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Anatomical correlates of behavior</subject><subject>Animal</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Electroshock</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Neurology</subject><subject>Pain Threshold - drug effects</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Raphe Nuclei</subject><subject>Raphe Nuclei - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Serotonin - metabolism</subject><subject>Shock</subject><subject>Spinal Cord</subject><subject>Spinal Cord - drug effects</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90ctO3DAUBmCrApVhyhMgVREq3WV6nOPY8RLRCyNRgXpZW47jgGnGTu1kwdvXoxlRxIKVN985tv-fkFMKKwooPoHAuhTA2IpSXLGVkPUbsqASZQnQsAOyeBJH5DilBwBgwOq35IgCkzU0YkE-r71NRo-6HWzx8z6YP-Xad7OxXXEbJusnpycXfBH64nuI473ztrjwerizyenC-eKHntI7ctjrIdmT_bkkv79--XV5VV7ffFtfXlyXmlE2lQyEhUpQDSDBCN4gQI9dhcApl20re4HUVD3rmG0q1tEeeYfQUsErrFmNS_Jxt3eM4e9s06Q2Lhk7DNrbMCcl8geFaJoMz17AhzDH_OykOGXIBVb8NVQBNlKynOWS4A6ZGFKKtldjdBsdHxUFta1BbUNW25BVrkExlWvIU-_3q-d2Y7tnM7vcM_iwBzqnP_RRe-PSfycrpBwzO9-xXJAa06PRcXJmsEm13j677x_3Cpga</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>Hammack, Sayamwong E</creator><creator>Hartley, Chad E</creator><creator>Lea, S. 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Elizabeth ; Maier, Steven F ; Watkins, Linda R ; Sutton, Lorraine C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a414t-407e0271a0090c768300f3d2306169bb9f731c2f4d4e824d1f36d30b176235453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Analgesia</topic><topic>Analgesics</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Anatomical correlates of behavior</topic><topic>Animal</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Electroshock</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Neurology</topic><topic>Pain Threshold - drug effects</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Raphe Nuclei</topic><topic>Raphe Nuclei - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Serotonin - metabolism</topic><topic>Shock</topic><topic>Spinal Cord</topic><topic>Spinal Cord - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hammack, Sayamwong E</creatorcontrib><creatorcontrib>Hartley, Chad E</creatorcontrib><creatorcontrib>Lea, S. Elizabeth</creatorcontrib><creatorcontrib>Maier, Steven F</creatorcontrib><creatorcontrib>Watkins, Linda R</creatorcontrib><creatorcontrib>Sutton, Lorraine C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hammack, Sayamwong E</au><au>Hartley, Chad E</au><au>Lea, S. Elizabeth</au><au>Maier, Steven F</au><au>Watkins, Linda R</au><au>Sutton, Lorraine C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inescapable Shock-Induced Potentiation of Morphine Analgesia in Rats: Sites of Action</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>113</volume><issue>4</issue><spage>795</spage><epage>803</epage><pages>795-803</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>Inescapable shock (IS) enhances analgesia to systemic
morphine (MOR) 24 hr later. IS activates serotonin neurons in the
dorsal raphe nucleus (DRN), rendering them hyperexcitable. These
studies tested whether IS potentiates the analgesic effect of MOR
microinjected in the DRN, as predicted by this hypothesis. To test
site specificity, the effect of previous IS was examined on MOR
microinjected lateral to the DRN and into 2 other sites that support
MOR analgesia, the nucleus raphe magnus (NRM) and spinal cord.
Twenty-four hours after IS, potentiated analgesia was observed after
0.5 μg MOR microinjected into, but not lateral to, the DRN.
Potentiated analgesia was also observed after NRM (1.0 μg) and
spinal cord (3.0 μg) MOR microinjections. These data suggest
that IS-induced excitability changes within the DRN synergize with
opiates microinjected in other analgesia areas and that this
potentiates the responses to opiates 24 hr after IS.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>10495087</pmid><doi>10.1037/0735-7044.113.4.795</doi><tpages>9</tpages></addata></record> |
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| ispartof | Behavioral neuroscience, 1999-08, Vol.113 (4), p.795-803 |
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| subjects | Analgesia Analgesics Analgesics, Opioid - pharmacology Anatomical correlates of behavior Animal Animals Behavioral psychophysiology Biological and medical sciences Electroshock Fundamental and applied biological sciences. Psychology Male Morphine Morphine - pharmacology Neurology Pain Threshold - drug effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Raphe Nuclei Raphe Nuclei - drug effects Rats Rats, Sprague-Dawley Rodents Serotonin - metabolism Shock Spinal Cord Spinal Cord - drug effects |
| title | Inescapable Shock-Induced Potentiation of Morphine Analgesia in Rats: Sites of Action |
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