RELATIONSHIP BETWEEN CONSTITUTIVE NITRIC OXIDE SYNTHASE ACTIVITY AND MUCUS LEVEL IN THE GASTRIC MUCOSA OF RATS WITH STRESS
A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric muc...
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| Veröffentlicht in: | Pharmacological research 1998-11, Vol.38 (5), p.393-397 |
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| creator | NISHIDA, KEIJI OHTA, YOSHIJI ISHIGURO, ISAO |
| description | A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric mucosal hexosamine and adherent mucus concentrations were enhanced with a further decrease in gastric mucosal cNOS activity by pretreatment withNG–monomethylL-arginine, a non-selective NOS inhibitor, but were prevented with maintenance of the gastric mucosal cNOS activity by pretreatment with aminoguanidine, a selective inducible NO synthase inhibitor. In all WIR-stressed rats used in this study, gastric mucosal cNOS activity was well correlated with either gastric mucosal hexosamine or adherent mucus concentration (r=0.717 or 0.739, respectively). These results indicate that in the gastric mucosa of WIR-stressed rats, a decrease in cNOS activity is closely related to a decrease in mucus level due to impairment of its synthesis and secretion. |
| doi_str_mv | 10.1006/phrs.1998.0379 |
| format | Article |
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The decreases in gastric mucosal hexosamine and adherent mucus concentrations were enhanced with a further decrease in gastric mucosal cNOS activity by pretreatment withNG–monomethylL-arginine, a non-selective NOS inhibitor, but were prevented with maintenance of the gastric mucosal cNOS activity by pretreatment with aminoguanidine, a selective inducible NO synthase inhibitor. In all WIR-stressed rats used in this study, gastric mucosal cNOS activity was well correlated with either gastric mucosal hexosamine or adherent mucus concentration (r=0.717 or 0.739, respectively). These results indicate that in the gastric mucosa of WIR-stressed rats, a decrease in cNOS activity is closely related to a decrease in mucus level due to impairment of its synthesis and secretion.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1006/phrs.1998.0379</identifier><identifier>PMID: 9806820</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Arginine - pharmacology ; Enzyme Inhibitors - pharmacology ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; gastric mucosal lesion, gastric mucus, hexosamine, nitric oxide synthase, water immersion restraint ; Guanidines - pharmacology ; Male ; Mucus - metabolism ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitric Oxide Synthase - metabolism ; Nitric Oxide Synthase Type III ; omega-N-Methylarginine - pharmacology ; Rats ; Rats, Wistar ; Stress, Physiological - metabolism</subject><ispartof>Pharmacological research, 1998-11, Vol.38 (5), p.393-397</ispartof><rights>1998 The Italian Pharmacological Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-9b355f418e3017e3ea6b8020dd683fe06847dbab3efaa5861482c62b0f29fb2c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/phrs.1998.0379$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9806820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NISHIDA, KEIJI</creatorcontrib><creatorcontrib>OHTA, YOSHIJI</creatorcontrib><creatorcontrib>ISHIGURO, ISAO</creatorcontrib><title>RELATIONSHIP BETWEEN CONSTITUTIVE NITRIC OXIDE SYNTHASE ACTIVITY AND MUCUS LEVEL IN THE GASTRIC MUCOSA OF RATS WITH STRESS</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric mucosal hexosamine and adherent mucus concentrations were enhanced with a further decrease in gastric mucosal cNOS activity by pretreatment withNG–monomethylL-arginine, a non-selective NOS inhibitor, but were prevented with maintenance of the gastric mucosal cNOS activity by pretreatment with aminoguanidine, a selective inducible NO synthase inhibitor. In all WIR-stressed rats used in this study, gastric mucosal cNOS activity was well correlated with either gastric mucosal hexosamine or adherent mucus concentration (r=0.717 or 0.739, respectively). These results indicate that in the gastric mucosa of WIR-stressed rats, a decrease in cNOS activity is closely related to a decrease in mucus level due to impairment of its synthesis and secretion.</description><subject>Animals</subject><subject>Arginine - pharmacology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>gastric mucosal lesion, gastric mucus, hexosamine, nitric oxide synthase, water immersion restraint</subject><subject>Guanidines - pharmacology</subject><subject>Male</subject><subject>Mucus - metabolism</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitric Oxide Synthase Type III</subject><subject>omega-N-Methylarginine - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stress, Physiological - metabolism</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9v0zAYhi0EGmNw5YbkE7eUz3Hq2MeQeYulkKDa3djJyg9HBLVrF7dI21-PQytunPxZz_u90vcg9JHAggCwL_ufk18QIfgCaCpeoUsCgkWEcPZ6nhMaMUb4W_TO-18AIBICF-hCcGA8hkv0spJlZlRd6UJ9x1-luZeywnn4G2XWRt1JXCmzUjmuf6hrifVDZYpMS5zlASrzgLPqGn9b52uNS3knS6wqbAqJbzP9dy2gWme4vsGrzGh8r0yBA5Fav0dvhmbj3Yfze4XWN9LkRVTWtyrPyqijVBwi0dLlckgIdxRI6qhrWMshhr5nnA4u3JGkfdu01A1Ns-SMJDzuWNzCEIuhjTt6hT6fevfT7uno_MFuR9-5zaZ5dLujtylAkiaUhODiFOymnfeTG-x-GrfN9GwJ2Fm2nWXbWbadZYeFT-fmY7t1_b_42W7g_MRdOO_36Cbru9E9dq4fJ9cdbL8b_1f9B1VIhJ8</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>NISHIDA, KEIJI</creator><creator>OHTA, YOSHIJI</creator><creator>ISHIGURO, ISAO</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981101</creationdate><title>RELATIONSHIP BETWEEN CONSTITUTIVE NITRIC OXIDE SYNTHASE ACTIVITY AND MUCUS LEVEL IN THE GASTRIC MUCOSA OF RATS WITH STRESS</title><author>NISHIDA, KEIJI ; OHTA, YOSHIJI ; ISHIGURO, ISAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-9b355f418e3017e3ea6b8020dd683fe06847dbab3efaa5861482c62b0f29fb2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Arginine - pharmacology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - metabolism</topic><topic>gastric mucosal lesion, gastric mucus, hexosamine, nitric oxide synthase, water immersion restraint</topic><topic>Guanidines - pharmacology</topic><topic>Male</topic><topic>Mucus - metabolism</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitric Oxide Synthase Type III</topic><topic>omega-N-Methylarginine - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stress, Physiological - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NISHIDA, KEIJI</creatorcontrib><creatorcontrib>OHTA, YOSHIJI</creatorcontrib><creatorcontrib>ISHIGURO, ISAO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NISHIDA, KEIJI</au><au>OHTA, YOSHIJI</au><au>ISHIGURO, ISAO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RELATIONSHIP BETWEEN CONSTITUTIVE NITRIC OXIDE SYNTHASE ACTIVITY AND MUCUS LEVEL IN THE GASTRIC MUCOSA OF RATS WITH STRESS</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>38</volume><issue>5</issue><spage>393</spage><epage>397</epage><pages>393-397</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric mucosal hexosamine and adherent mucus concentrations were enhanced with a further decrease in gastric mucosal cNOS activity by pretreatment withNG–monomethylL-arginine, a non-selective NOS inhibitor, but were prevented with maintenance of the gastric mucosal cNOS activity by pretreatment with aminoguanidine, a selective inducible NO synthase inhibitor. In all WIR-stressed rats used in this study, gastric mucosal cNOS activity was well correlated with either gastric mucosal hexosamine or adherent mucus concentration (r=0.717 or 0.739, respectively). These results indicate that in the gastric mucosa of WIR-stressed rats, a decrease in cNOS activity is closely related to a decrease in mucus level due to impairment of its synthesis and secretion.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>9806820</pmid><doi>10.1006/phrs.1998.0379</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-6618 |
| ispartof | Pharmacological research, 1998-11, Vol.38 (5), p.393-397 |
| issn | 1043-6618 1096-1186 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Arginine - pharmacology Enzyme Inhibitors - pharmacology Gastric Mucosa - drug effects Gastric Mucosa - metabolism gastric mucosal lesion, gastric mucus, hexosamine, nitric oxide synthase, water immersion restraint Guanidines - pharmacology Male Mucus - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III omega-N-Methylarginine - pharmacology Rats Rats, Wistar Stress, Physiological - metabolism |
| title | RELATIONSHIP BETWEEN CONSTITUTIVE NITRIC OXIDE SYNTHASE ACTIVITY AND MUCUS LEVEL IN THE GASTRIC MUCOSA OF RATS WITH STRESS |
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