Serum thrombopoietin levels in haemodialysis patients: involvement of arteriovenous fistula

Background. Thrombopoietin (Tpo) is a recently cloned growth factor which plays a critical role in the regulation of thrombopoiesis. Tpo has also been shown to stimulate in vitro and in vivo erythroid cell growth. Although Tpo transcripts were detected in hepatocytes, proximal tubules and endotheliu...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 1999-09, Vol.14 (9), p.2173-2177
Hauptverfasser:	Altun, Bülent, Arici, Mustafa, Haznedaroglu, İ. Celalettin, Usalan, Celalettin, Erdem, Yunus, Yasavul, Ünal, Turgan, Çetin, Çaglar, Şali, Kirazli, Şerafettin
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Schlagworte:	Adolescent Adult Aged Anastomosis, Surgical Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arteries - physiopathology Arteries - surgery arteriovenous fistula Biological and medical sciences Emergency and intensive care: renal failure. Dialysis management erythropoietin Erythropoietin - blood Erythropoietin - therapeutic use Female haemodialysis Humans Intensive care medicine Kidney Failure, Chronic - blood Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Male Medical sciences Middle Aged Recombinant Proteins Reference Values Regional Blood Flow Renal Dialysis thrombopoietin Thrombopoietin - blood Veins - physiopathology Veins - surgery
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container_title	Nephrology, dialysis, transplantation
container_volume	14
creator	Altun, Bülent Arici, Mustafa Haznedaroglu, İ. Celalettin Usalan, Celalettin Erdem, Yunus Yasavul, Ünal Turgan, Çetin Çaglar, Şali Kirazli, Şerafettin
description	Background. Thrombopoietin (Tpo) is a recently cloned growth factor which plays a critical role in the regulation of thrombopoiesis. Tpo has also been shown to stimulate in vitro and in vivo erythroid cell growth. Although Tpo transcripts were detected in hepatocytes, proximal tubules and endothelium, mechanisms regulating the level of circulating Tpo have not been fully delineated. Changes in the vessel wall and blood flow in arteriovenous fistula (AVF) might alter Tpo activity. Methods. Serum thrombopoietin levels and serum erythropoietin levels in samples concurrently obtained from venous returns of AVF and contralateral peripheral veins in 31 haemodialysis patients were determined and compared with 12 healthy controls. Levels were also compared between 14 haemodialysis patients (group I) treated with recombinant human erythropoietin (rHu-Epo) and 17 haemodialysis patients (group II) not requiring rHu-Epo. Results. Serum Tpo levels (44.8±23.9 pg/ml, vs 129.9±113.6 pg/ml, P
doi_str_mv	10.1093/ndt/14.9.2173
format	Article
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Celalettin ; Usalan, Celalettin ; Erdem, Yunus ; Yasavul, Ünal ; Turgan, Çetin ; Çaglar, Şali ; Kirazli, Şerafettin</creator><creatorcontrib>Altun, Bülent ; Arici, Mustafa ; Haznedaroglu, İ. Celalettin ; Usalan, Celalettin ; Erdem, Yunus ; Yasavul, Ünal ; Turgan, Çetin ; Çaglar, Şali ; Kirazli, Şerafettin</creatorcontrib><description>Background. Thrombopoietin (Tpo) is a recently cloned growth factor which plays a critical role in the regulation of thrombopoiesis. Tpo has also been shown to stimulate in vitro and in vivo erythroid cell growth. Although Tpo transcripts were detected in hepatocytes, proximal tubules and endothelium, mechanisms regulating the level of circulating Tpo have not been fully delineated. Changes in the vessel wall and blood flow in arteriovenous fistula (AVF) might alter Tpo activity. Methods. Serum thrombopoietin levels and serum erythropoietin levels in samples concurrently obtained from venous returns of AVF and contralateral peripheral veins in 31 haemodialysis patients were determined and compared with 12 healthy controls. Levels were also compared between 14 haemodialysis patients (group I) treated with recombinant human erythropoietin (rHu-Epo) and 17 haemodialysis patients (group II) not requiring rHu-Epo. Results. Serum Tpo levels (44.8±23.9 pg/ml, vs 129.9±113.6 pg/ml, P<0.05) and platelet counts (194±55. 106/ml vs 273±94. 106/ml, P<0.05) of haemodialysis patients were lower than healthy controls. Serum Tpo levels were inversely correlated with platelet counts in the control group (R=−0.61, P<0.05), but not in haemodialysis patients. Tpo concentrations of AVF samples were lower than peripheral venous samples (31.6±17.7 pg/ml vs 44.8±23.9 pg/ml, P=0.001). No significant difference was present between the serum Tpo concentrations of haemodialysis patients in group I and group II. Serum Tpo levels were not correlated with haemoglobin levels or serum erythropoietin levels in haemodialysis patients. Conclusion. Decreased serum Tpo levels despite low platelet counts in haemodialysis patients suggest that the proposed feedback mechanism of platelet uptake of Tpo is not fully operative in these patients. Moreover, AVF might affect the local production and/or catabolism of this growth factor.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/14.9.2173</identifier><identifier>PMID: 10489227</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Anastomosis, Surgical ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Arteries - physiopathology ; Arteries - surgery ; arteriovenous fistula ; Biological and medical sciences ; Emergency and intensive care: renal failure. Dialysis management ; erythropoietin ; Erythropoietin - blood ; Erythropoietin - therapeutic use ; Female ; haemodialysis ; Humans ; Intensive care medicine ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - physiopathology ; Kidney Failure, Chronic - therapy ; Male ; Medical sciences ; Middle Aged ; Recombinant Proteins ; Reference Values ; Regional Blood Flow ; Renal Dialysis ; thrombopoietin ; Thrombopoietin - blood ; Veins - physiopathology ; Veins - surgery</subject><ispartof>Nephrology, dialysis, transplantation, 1999-09, Vol.14 (9), p.2173-2177</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-79b96ffb9334f55c4624bb002be885fbe6c0f5437538917e2be4db747c53c8fa3</citedby><cites>FETCH-LOGICAL-c395t-79b96ffb9334f55c4624bb002be885fbe6c0f5437538917e2be4db747c53c8fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,777,781,786,787,23911,23912,25121,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1932491$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10489227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Altun, Bülent</creatorcontrib><creatorcontrib>Arici, Mustafa</creatorcontrib><creatorcontrib>Haznedaroglu, İ. Celalettin</creatorcontrib><creatorcontrib>Usalan, Celalettin</creatorcontrib><creatorcontrib>Erdem, Yunus</creatorcontrib><creatorcontrib>Yasavul, Ünal</creatorcontrib><creatorcontrib>Turgan, Çetin</creatorcontrib><creatorcontrib>Çaglar, Şali</creatorcontrib><creatorcontrib>Kirazli, Şerafettin</creatorcontrib><title>Serum thrombopoietin levels in haemodialysis patients: involvement of arteriovenous fistula</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol. Dial. Transplant</addtitle><description>Background. Thrombopoietin (Tpo) is a recently cloned growth factor which plays a critical role in the regulation of thrombopoiesis. Tpo has also been shown to stimulate in vitro and in vivo erythroid cell growth. Although Tpo transcripts were detected in hepatocytes, proximal tubules and endothelium, mechanisms regulating the level of circulating Tpo have not been fully delineated. Changes in the vessel wall and blood flow in arteriovenous fistula (AVF) might alter Tpo activity. Methods. Serum thrombopoietin levels and serum erythropoietin levels in samples concurrently obtained from venous returns of AVF and contralateral peripheral veins in 31 haemodialysis patients were determined and compared with 12 healthy controls. Levels were also compared between 14 haemodialysis patients (group I) treated with recombinant human erythropoietin (rHu-Epo) and 17 haemodialysis patients (group II) not requiring rHu-Epo. Results. Serum Tpo levels (44.8±23.9 pg/ml, vs 129.9±113.6 pg/ml, P<0.05) and platelet counts (194±55. 106/ml vs 273±94. 106/ml, P<0.05) of haemodialysis patients were lower than healthy controls. Serum Tpo levels were inversely correlated with platelet counts in the control group (R=−0.61, P<0.05), but not in haemodialysis patients. Tpo concentrations of AVF samples were lower than peripheral venous samples (31.6±17.7 pg/ml vs 44.8±23.9 pg/ml, P=0.001). No significant difference was present between the serum Tpo concentrations of haemodialysis patients in group I and group II. Serum Tpo levels were not correlated with haemoglobin levels or serum erythropoietin levels in haemodialysis patients. Conclusion. Decreased serum Tpo levels despite low platelet counts in haemodialysis patients suggest that the proposed feedback mechanism of platelet uptake of Tpo is not fully operative in these patients. Moreover, AVF might affect the local production and/or catabolism of this growth factor.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anastomosis, Surgical</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Arteries - physiopathology</subject><subject>Arteries - surgery</subject><subject>arteriovenous fistula</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>erythropoietin</subject><subject>Erythropoietin - blood</subject><subject>Erythropoietin - therapeutic use</subject><subject>Female</subject><subject>haemodialysis</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Recombinant Proteins</subject><subject>Reference Values</subject><subject>Regional Blood Flow</subject><subject>Renal Dialysis</subject><subject>thrombopoietin</subject><subject>Thrombopoietin - blood</subject><subject>Veins - physiopathology</subject><subject>Veins - surgery</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM9rFDEUx4Modq0evcocxNts83My8SZFt8KCYJWKHkKSfaHRzGRNMov9703ZxXrKS74f3sv7IPSS4DXBil3Mu3pB-FqtKZHsEVoRPuCeslE8RquWkx4LrM7Qs1J-YowVlfIpOiOYj4pSuUI_riEvU1dvc5ps2qcANcxdhAPE0rXq1sCUdsHEuxJKtzc1wFzL2xYdUjzA1G5d8p3JFXJIB5jTUjofSl2ieY6eeBMLvDid5-jrh_dfLq_67afNx8t3294xJWovlVWD91Yxxr0Qjg-UW4sxtTCOwlsYHPaCMynYqIiE9s53VnLpBHOjN-wcvTn23ef0e4FS9RSKgxjNDO07WmLMByVpA_sj6HIqJYPX-xwmk-80wfrepm42NeFa6XubjX91arzYCXb_0Ud9DXh9AkxxJvpsZhfKA6cY5Yo8zG1e4M-_2ORfepBtL3317bv-vLnZXG-HGz2yv2pljrY</recordid><startdate>19990901</startdate><enddate>19990901</enddate><creator>Altun, Bülent</creator><creator>Arici, Mustafa</creator><creator>Haznedaroglu, İ. Celalettin</creator><creator>Usalan, Celalettin</creator><creator>Erdem, Yunus</creator><creator>Yasavul, Ünal</creator><creator>Turgan, Çetin</creator><creator>Çaglar, Şali</creator><creator>Kirazli, Şerafettin</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990901</creationdate><title>Serum thrombopoietin levels in haemodialysis patients: involvement of arteriovenous fistula</title><author>Altun, Bülent ; Arici, Mustafa ; Haznedaroglu, İ. Celalettin ; Usalan, Celalettin ; Erdem, Yunus ; Yasavul, Ünal ; Turgan, Çetin ; Çaglar, Şali ; Kirazli, Şerafettin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-79b96ffb9334f55c4624bb002be885fbe6c0f5437538917e2be4db747c53c8fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anastomosis, Surgical</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Arteries - physiopathology</topic><topic>Arteries - surgery</topic><topic>arteriovenous fistula</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>erythropoietin</topic><topic>Erythropoietin - blood</topic><topic>Erythropoietin - therapeutic use</topic><topic>Female</topic><topic>haemodialysis</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Recombinant Proteins</topic><topic>Reference Values</topic><topic>Regional Blood Flow</topic><topic>Renal Dialysis</topic><topic>thrombopoietin</topic><topic>Thrombopoietin - blood</topic><topic>Veins - physiopathology</topic><topic>Veins - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Altun, Bülent</creatorcontrib><creatorcontrib>Arici, Mustafa</creatorcontrib><creatorcontrib>Haznedaroglu, İ. Celalettin</creatorcontrib><creatorcontrib>Usalan, Celalettin</creatorcontrib><creatorcontrib>Erdem, Yunus</creatorcontrib><creatorcontrib>Yasavul, Ünal</creatorcontrib><creatorcontrib>Turgan, Çetin</creatorcontrib><creatorcontrib>Çaglar, Şali</creatorcontrib><creatorcontrib>Kirazli, Şerafettin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altun, Bülent</au><au>Arici, Mustafa</au><au>Haznedaroglu, İ. Celalettin</au><au>Usalan, Celalettin</au><au>Erdem, Yunus</au><au>Yasavul, Ünal</au><au>Turgan, Çetin</au><au>Çaglar, Şali</au><au>Kirazli, Şerafettin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum thrombopoietin levels in haemodialysis patients: involvement of arteriovenous fistula</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol. Dial. Transplant</addtitle><date>1999-09-01</date><risdate>1999</risdate><volume>14</volume><issue>9</issue><spage>2173</spage><epage>2177</epage><pages>2173-2177</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. Thrombopoietin (Tpo) is a recently cloned growth factor which plays a critical role in the regulation of thrombopoiesis. Tpo has also been shown to stimulate in vitro and in vivo erythroid cell growth. Although Tpo transcripts were detected in hepatocytes, proximal tubules and endothelium, mechanisms regulating the level of circulating Tpo have not been fully delineated. Changes in the vessel wall and blood flow in arteriovenous fistula (AVF) might alter Tpo activity. Methods. Serum thrombopoietin levels and serum erythropoietin levels in samples concurrently obtained from venous returns of AVF and contralateral peripheral veins in 31 haemodialysis patients were determined and compared with 12 healthy controls. Levels were also compared between 14 haemodialysis patients (group I) treated with recombinant human erythropoietin (rHu-Epo) and 17 haemodialysis patients (group II) not requiring rHu-Epo. Results. Serum Tpo levels (44.8±23.9 pg/ml, vs 129.9±113.6 pg/ml, P<0.05) and platelet counts (194±55. 106/ml vs 273±94. 106/ml, P<0.05) of haemodialysis patients were lower than healthy controls. Serum Tpo levels were inversely correlated with platelet counts in the control group (R=−0.61, P<0.05), but not in haemodialysis patients. Tpo concentrations of AVF samples were lower than peripheral venous samples (31.6±17.7 pg/ml vs 44.8±23.9 pg/ml, P=0.001). No significant difference was present between the serum Tpo concentrations of haemodialysis patients in group I and group II. Serum Tpo levels were not correlated with haemoglobin levels or serum erythropoietin levels in haemodialysis patients. Conclusion. Decreased serum Tpo levels despite low platelet counts in haemodialysis patients suggest that the proposed feedback mechanism of platelet uptake of Tpo is not fully operative in these patients. Moreover, AVF might affect the local production and/or catabolism of this growth factor.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>10489227</pmid><doi>10.1093/ndt/14.9.2173</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects	Adolescent Adult Aged Anastomosis, Surgical Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arteries - physiopathology Arteries - surgery arteriovenous fistula Biological and medical sciences Emergency and intensive care: renal failure. Dialysis management erythropoietin Erythropoietin - blood Erythropoietin - therapeutic use Female haemodialysis Humans Intensive care medicine Kidney Failure, Chronic - blood Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Male Medical sciences Middle Aged Recombinant Proteins Reference Values Regional Blood Flow Renal Dialysis thrombopoietin Thrombopoietin - blood Veins - physiopathology Veins - surgery
title	Serum thrombopoietin levels in haemodialysis patients: involvement of arteriovenous fistula
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