Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1)

The enzyme pteridine reductase (PTR1) has recently been discovered in the protozoan parasite Leishmania and validated as a target for therapeutic intervention. PTR1 is responsible for the salvage of pteridines and also contributes to antifolate drug resistance. Structural analysis, in combination wi...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 1999-09, Vol.55 (9), p.1608-1610
Hauptverfasser:	Gourley, David G., Luba, James, Hardy, Larry W., Beverley, Stephen M., Hunter, William N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - chemistry Bacterial Proteins - genetics Crystallization Leishmania major Leishmania major - enzymology methotrexate resistance Oxidoreductases - chemistry Oxidoreductases - genetics pteridine reductase Recombinant Proteins - chemistry X-Ray Diffraction
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