DIVERGENT EFFECTS OF LPS ON EXPRESSION OF IL-1 RECEPTOR FAMILY MEMBERS IN MONONUCLEAR PHAGOCYTES IN VITRO AND IN VIVO

Three molecules, interleukin 1 (IL-1) receptor I (IL-1RI), IL-1 receptor II (IL-1RII or decoy) and IL-1 receptor accessory protein (IL-1R AcP or IL-1RIII), are involved in IL-1 binding and signal transduction. In addition, three homologous genes (T1/ST2, MyD88 and rsc786) have been identified. Expre...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 1998-10, Vol.10 (10), p.773-780
Hauptverfasser:	Saccani, Simona, Polentarutti, Nadia, Penton-Rol, Giselle, Sims, John E., Mantovani, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Antigens, Differentiation Cycloheximide - pharmacology Dactinomycin - pharmacology expression/LPS/IL-1R family/monocytes Humans Interleukin-1 Receptor-Like 1 Protein Lipopolysaccharides - pharmacology Male Membrane Proteins Mice Monocytes - drug effects Monocytes - metabolism Myeloid Differentiation Factor 88 Protein Synthesis Inhibitors - pharmacology Proteins - metabolism Receptors, Cell Surface Receptors, Immunologic Receptors, Interleukin Receptors, Interleukin-1 - metabolism Tissue Distribution
Online-Zugang:	Volltext
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