Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus

The aim of this study was to investigate the humoral immune response to Borna disease (BD) virus in the brain of experimentally infected Lewis rats. Abundant IgG was detected in BD-rat brain with isotype variation throughout infection. IgG was locally produced as indicated by an intact blood–brain b...

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Veröffentlicht in:	Journal of neuroimmunology 1998-10, Vol.90 (2), p.128-136
Hauptverfasser:	Hatalski, Carolyn G., Hickey, William F., Lipkin, W.Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - biosynthesis Antibodies, Viral - physiology Antibody penetration Blood-Brain Barrier Borna Disease - immunology Borna disease virus - genetics Borna disease virus - immunology Brain - immunology Gene Expression Regulation, Viral Immunoglobulin G - biosynthesis Immunoglobulin isotype Immunoglobulin Isotypes - biosynthesis Immunoglobulin kappa-Chains - genetics Persistent infection Plasma cells Rats Rats, Inbred Lew RNA, Messenger - analysis Viral gene expression
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