Diphosphoinositol Polyphosphates: The Final Frontier for Inositide Research?
The diphosphoinositol polyphosphates comprise a group of highly phosphorylated compounds which have a rapid rate of metabolic turnover through tightly-regulated kinase/phosphohydrolase substrate cycles. The phosphohydrolases occur as multiple isoforms, the expression of which is apparently carefully...
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| Veröffentlicht in: | Biological chemistry 1999-07, Vol.380 (7-8), p.945-951 |
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| container_title | Biological chemistry |
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| creator | Safrany, S. T. Caffrey, J. J. Yang, X. Shears, S. B. |
| description | The diphosphoinositol polyphosphates comprise a group of highly phosphorylated compounds which have a rapid rate of metabolic turnover through tightly-regulated kinase/phosphohydrolase substrate cycles. The phosphohydrolases occur as multiple isoforms, the expression of which is apparently carefully controlled. Cellular levels of the diphosphoinositol polyphosphates are regulated by cAMP and cGMP in a protein kinase-independent manner. These inositides can also sense a specific mode of intracellular Ca2+ pool depletion. In this review, we will argue that these are characteristics of highly significant cellular molecules. |
| doi_str_mv | 10.1515/BC.1999.117 |
| format | Article |
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In this review, we will argue that these are characteristics of highly significant cellular molecules.</description><subject>Acid Anhydride Hydrolases - metabolism</subject><subject>Inositol Phosphates - chemistry</subject><subject>Inositol Phosphates - metabolism</subject><subject>Molecular Structure</subject><subject>Phosphorylation</subject><subject>Signal Transduction</subject><issn>1431-6730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1Lw0AQQPeg2Fo9eZecvEjqzu7my4vYaG0xYJUK4mXZJBO6mnbrbgr235uaIh6GgZnHOzxCzoAOIYDgapQOIUmSIUB0QPogOPhhxGmPHDv3QSmNqeBHpAdUJCIWYZ9kd3q9MK4dvTJON6b2ZqbedjfVoLv25gv0xnqlam9szarRaL3KWG_6y-sSvRd0qGyxuDkhh5WqHZ7u94C8ju_n6cTPnh6m6W3mF5zxxk84KBZCBZgURVSIkFLBkLIQkyoWqFSUY1lxpkqgEEOe50xFQY4xwwpEKfiAXHTetTVfG3SNXGpXYF2rFZqNk1Er5HHMW_CyAwtrnLNYybXVS2W3EqjcBZOjVO6CyTZYS5_vtZt8ieU_tqvVAn4HaNfg999f2U_ZVo4C-TwXcvQ2yR5nLJLv_Af8O3eM</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Safrany, S. 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| ispartof | Biological chemistry, 1999-07, Vol.380 (7-8), p.945-951 |
| issn | 1431-6730 |
| language | eng |
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| source | MEDLINE; De Gruyter journals |
| subjects | Acid Anhydride Hydrolases - metabolism Inositol Phosphates - chemistry Inositol Phosphates - metabolism Molecular Structure Phosphorylation Signal Transduction |
| title | Diphosphoinositol Polyphosphates: The Final Frontier for Inositide Research? |
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