The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation

Some widely used antidepressants such as imipramine, clomipramine, and citalopram have been found to possess antineoplastic effects. In the present study, these compounds were found to induce apoptotic cell death in human acute myeloid leukemia HL‐60 cells. Apoptosis induced by the antidepressants w...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 1999, Vol.13 (6), p.338-347
Hauptverfasser:	Xia, Zhenlei, Bergstrand, Anders, DePierre, Joseph W., Nässberger, Lennart
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressants Antidepressive Agents - pharmacology Apoptosis Apoptosis - drug effects Caspase 3 Caspase-3 (CPP32) Caspases - metabolism Citalopram - pharmacology Clomipramine - pharmacology DNA Fragmentation - drug effects Flow Cytometry HL-60 HL-60 Cells - drug effects HL-60 Cells - enzymology HL-60 Cells - ultrastructure Humans Imipramine - pharmacology In Situ Nick-End Labeling Leukemia, Promyelocytic, Acute - pathology Reactive Oxygen Species Reactive Oxygen Species - metabolism
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