Montelukast reduces airway eosinophilic inflammation in asthma: a randomized, controlled trial

Leukotrienes are pro‐inflammatory mediators which may contribute to tissue, sputum, and blood eosinophilia seen in allergic and inflammatory diseases, including asthma. Montelukast is a cysteinyl leukotriene1 (CysLT1) receptor antagonist which improves asthma control; the aim of this study was to in...

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Veröffentlicht in:	The European respiratory journal 1999-07, Vol.14 (1), p.12-18
Hauptverfasser:	Pizzichini, E, Leff, JA, Reiss, TF, Hendeles, L, Boulet, LP, Wei, LX, Efthimiadis, AE, Zhang, J, Hargreave, FE
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - therapeutic use Adult Airway inflammation asthma Asthma - complications Asthma - drug therapy Asthma - physiopathology Biological and medical sciences cysteinyl leukotriene receptor antagonists Double-Blind Method Eosinophils - drug effects Female Humans Leukocyte Count - drug effects Leukotriene Antagonists - therapeutic use Male Medical sciences Middle Aged montelukast Pharmacology. Drug treatments Pulmonary Eosinophilia - complications Pulmonary Eosinophilia - drug therapy Pulmonary Eosinophilia - physiopathology Quinolines - therapeutic use Respiratory Function Tests Respiratory system Respiratory Tract Diseases - complications Respiratory Tract Diseases - drug therapy Respiratory Tract Diseases - pathology Safety Sputum - cytology Sputum - drug effects sputum eosinophils Treatment Outcome
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