Topical treatment with hexadecylphosphocholine (Miltex ®) efficiently reduces parasite burden in experimental cutaneous leishmaniasis

Ether-lipids and alkylphosphocholines have been found to have anti-leishmanial activity. Oral treatment with hexadecylphosphocholine (HePC) efficiently reduces parasite burden in murine visceral leishmaniasis. Drugs for the treatment of cutaneous leishmaniasis are most commonly administered parenter...

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Veröffentlicht in:	Transactions of the Royal Society of Tropical Medicine and Hygiene 1999, Vol.93 (1), p.85-90
Hauptverfasser:	Schmidt-Ott, Ruprecht, Klenner, Thomas, Overath, Peter, Aebischer, Toni
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiprotozoal Agents - therapeutic use Biological and medical sciences CD4-Positive T-Lymphocytes - parasitology Drug Evaluation, Preclinical experimental infections Experimental protozoal diseases and models Female hexadecylphosphocholine Infectious diseases Leishmania major Leishmania mexicana Leishmania mexicana - isolation & purification Leishmaniasis, Cutaneous - drug therapy Leishmaniasis, Cutaneous - parasitology Lymphatic Diseases - parasitology Medical sciences Mice Mice, Inbred Strains Parasitic diseases Pharmacology. Drug treatments Phosphorylcholine - analogs & derivatives Phosphorylcholine - therapeutic use Protozoal diseases topical treatment Tropical medicine
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