Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women

Background-The genetic background of hereditary hemochromatosis (HH) is homozygosity for a cysteine-to-tyrosine transition at position 282 in the HFE gene. Heterozygosity for HH is associated with moderately increased iron levels and could be a risk factor for cardiovascular death. Methods and Resul...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1999-09, Vol.100 (12), p.1268-1273
Hauptverfasser:	ROEST, M, VAN DER SCHOUW, Y. T, DE VALK, B, MARX, J. J. M, TEMPELMAN, M. J, DE GROOT, P. G, SIXMA, J. J, BANGA, J. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - mortality Cerebrovascular Disorders - mortality Female Hemochromatosis - genetics Hemochromatosis Protein Heterozygote Histocompatibility Antigens Class I - genetics HLA Antigens - genetics Humans Medical sciences Membrane Proteins Middle Aged Myocardial Infarction - mortality Polymerase Chain Reaction Risk Factors
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