Nail Changes in Patients Infected With Human Immunodeficiency Virus: A Prospective Controlled Study
OBJECTIVES To study the frequency of nail changes in a population of human immunodeficiency virus (HIV)–infected patients and to evaluate the specificity of these findings by comparison with HIV-negative control subjects. DESIGN Prospective controlled study. Nail changes were recorded by a standardi...
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| Veröffentlicht in: | Archives of dermatology (1960) 1998-10, Vol.134 (10), p.1216-1220 |
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| container_title | Archives of dermatology (1960) |
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| creator | Cribier, Bernard Mena, Marcello Leiva Rey, David Partisani, Maria Fabien, Vincent Lang, Jean-Marie Grosshans, Edouard |
| description | OBJECTIVES To study the frequency of nail changes in a population of human immunodeficiency virus (HIV)–infected patients and to evaluate the specificity of these findings by comparison with HIV-negative control subjects. DESIGN Prospective controlled study. Nail changes were recorded by a standardized clinical examination (curvature, nail plate, color, onychomycosis). In case of clinical diagnosis of onychomycosis, mycological culture was performed. SETTING Primary care university hospital. PATIENTS A total of 155 HIV-1–positive patients and 103 healthy HIV-negative control subjects of comparable age and sex ratio. INTERVENTION None. MAIN OUTCOME MEASURE Clinical examination findings. RESULTS Nail symptoms were present in 67.7% of HIV-positive patients vs 34.0% of controls (P |
| doi_str_mv | 10.1001/archderm.134.10.1216 |
| format | Article |
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DESIGN Prospective controlled study. Nail changes were recorded by a standardized clinical examination (curvature, nail plate, color, onychomycosis). In case of clinical diagnosis of onychomycosis, mycological culture was performed. SETTING Primary care university hospital. PATIENTS A total of 155 HIV-1–positive patients and 103 healthy HIV-negative control subjects of comparable age and sex ratio. INTERVENTION None. MAIN OUTCOME MEASURE Clinical examination findings. RESULTS Nail symptoms were present in 67.7% of HIV-positive patients vs 34.0% of controls (P<<.001). The following symptoms were significantly more frequent in the HIV group: clubbing (5.8%) (P<.05), transverse lines (7.1%) (P<.01), onychoschizia (7.1%) (P<.05), leukonychia (14.3%) (P<.001), and longitudinal melanonychia (14.8%) (P<.01). The main finding was onychomycosis in 30.3% of patients vs 12.6% of controls (P<.001). Trichophyton rubrum was present in 48% of onychomycoses and unusual Candida species were also recorded. Multiple fungi were frequently cultured in a single patient. The mean CD4+ cell count was lower in patients with onychomycosis and the frequency of onychomycosis increased in advanced stages of HIV disease. Acquired total leukonychia of the 20 nails was present in 4% of patients. CONCLUSION Nail symptoms are much more frequent in patients with HIV than in healthy controls, and some of them could be linked to the level of immunosuppression.-->]]></description><identifier>ISSN: 0003-987X</identifier><identifier>ISSN: 2168-6068</identifier><identifier>EISSN: 1538-3652</identifier><identifier>EISSN: 2168-6084</identifier><identifier>DOI: 10.1001/archderm.134.10.1216</identifier><identifier>PMID: 9801676</identifier><identifier>CODEN: ARDEAC</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adult ; Aged ; AIDS/HIV ; Biological and medical sciences ; Dermatology ; Female ; Hair and nails disorders ; HIV Infections - complications ; Humans ; Male ; Medical sciences ; Middle Aged ; Nail Diseases - complications ; Nail Diseases - epidemiology ; Prospective Studies</subject><ispartof>Archives of dermatology (1960), 1998-10, Vol.134 (10), p.1216-1220</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright American Medical Association Oct 1998</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamadermatology/articlepdf/10.1001/archderm.134.10.1216$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/archderm.134.10.1216$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,780,784,3340,27924,27925,76489,76492</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2429468$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9801676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cribier, Bernard</creatorcontrib><creatorcontrib>Mena, Marcello Leiva</creatorcontrib><creatorcontrib>Rey, David</creatorcontrib><creatorcontrib>Partisani, Maria</creatorcontrib><creatorcontrib>Fabien, Vincent</creatorcontrib><creatorcontrib>Lang, Jean-Marie</creatorcontrib><creatorcontrib>Grosshans, Edouard</creatorcontrib><title>Nail Changes in Patients Infected With Human Immunodeficiency Virus: A Prospective Controlled Study</title><title>Archives of dermatology (1960)</title><addtitle>Arch Dermatol</addtitle><description><![CDATA[OBJECTIVES To study the frequency of nail changes in a population of human immunodeficiency virus (HIV)–infected patients and to evaluate the specificity of these findings by comparison with HIV-negative control subjects. DESIGN Prospective controlled study. Nail changes were recorded by a standardized clinical examination (curvature, nail plate, color, onychomycosis). In case of clinical diagnosis of onychomycosis, mycological culture was performed. SETTING Primary care university hospital. PATIENTS A total of 155 HIV-1–positive patients and 103 healthy HIV-negative control subjects of comparable age and sex ratio. INTERVENTION None. MAIN OUTCOME MEASURE Clinical examination findings. RESULTS Nail symptoms were present in 67.7% of HIV-positive patients vs 34.0% of controls (P<<.001). The following symptoms were significantly more frequent in the HIV group: clubbing (5.8%) (P<.05), transverse lines (7.1%) (P<.01), onychoschizia (7.1%) (P<.05), leukonychia (14.3%) (P<.001), and longitudinal melanonychia (14.8%) (P<.01). The main finding was onychomycosis in 30.3% of patients vs 12.6% of controls (P<.001). Trichophyton rubrum was present in 48% of onychomycoses and unusual Candida species were also recorded. Multiple fungi were frequently cultured in a single patient. The mean CD4+ cell count was lower in patients with onychomycosis and the frequency of onychomycosis increased in advanced stages of HIV disease. Acquired total leukonychia of the 20 nails was present in 4% of patients. CONCLUSION Nail symptoms are much more frequent in patients with HIV than in healthy controls, and some of them could be linked to the level of immunosuppression.-->]]></description><subject>Adult</subject><subject>Aged</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Female</subject><subject>Hair and nails disorders</subject><subject>HIV Infections - complications</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nail Diseases - complications</subject><subject>Nail Diseases - epidemiology</subject><subject>Prospective Studies</subject><issn>0003-987X</issn><issn>2168-6068</issn><issn>1538-3652</issn><issn>2168-6084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtq3DAQhkVJSbdpHyCQgCild97qYNly7palbRZCG8ihvTPyWOoq2PJGsgP79pl0NynkamDm--f0E3LC2Zwzxr-aCOvWxn7OZT5_SgpevCEzrqTOZKHEAZkxxmRW6fLPO_I-pTtUCa3FITmsNONFWcwI_DS-o8u1CX9toj7QSzN6G8ZEV8FZGG1Lf_txTc-n3gS66vspDK11HhCCLb31cUpndEEv45A2yPsHS5dDGOPQdai9Gqd2-4G8daZL9uM-HpGb79-ul-fZxa8fq-XiIjNSqDEDaaEChfsXoETbVC5vLbSNZMI5ANFAnpfOyKbUmileMqtK4TRnjTYOaXlEvuz6buJwP9k01r1PYLvOBDtMqS7xGxWTBYKfXoF3wxQD7lYLKTlXquAI5TsI8LQUras30fcmbmvO6icD6mcDajTgXxINQNnpvvfU9LZ9Ee0_jvXP-7pJYDoXTQCfXjCRiyovNGLHO8z05v9gXeV4wCMbgZkL</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>Cribier, Bernard</creator><creator>Mena, Marcello Leiva</creator><creator>Rey, David</creator><creator>Partisani, Maria</creator><creator>Fabien, Vincent</creator><creator>Lang, Jean-Marie</creator><creator>Grosshans, Edouard</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19981001</creationdate><title>Nail Changes in Patients Infected With Human Immunodeficiency Virus: A Prospective Controlled Study</title><author>Cribier, Bernard ; Mena, Marcello Leiva ; Rey, David ; Partisani, Maria ; Fabien, Vincent ; Lang, Jean-Marie ; Grosshans, Edouard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a325t-c3ec9c51536c52db9f4decdb302ffcc2bc447fa3b78805170e572f810b8afb9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Female</topic><topic>Hair and nails disorders</topic><topic>HIV Infections - complications</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nail Diseases - complications</topic><topic>Nail Diseases - epidemiology</topic><topic>Prospective Studies</topic><toplevel>online_resources</toplevel><creatorcontrib>Cribier, Bernard</creatorcontrib><creatorcontrib>Mena, Marcello Leiva</creatorcontrib><creatorcontrib>Rey, David</creatorcontrib><creatorcontrib>Partisani, Maria</creatorcontrib><creatorcontrib>Fabien, Vincent</creatorcontrib><creatorcontrib>Lang, Jean-Marie</creatorcontrib><creatorcontrib>Grosshans, Edouard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of dermatology (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cribier, Bernard</au><au>Mena, Marcello Leiva</au><au>Rey, David</au><au>Partisani, Maria</au><au>Fabien, Vincent</au><au>Lang, Jean-Marie</au><au>Grosshans, Edouard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nail Changes in Patients Infected With Human Immunodeficiency Virus: A Prospective Controlled Study</atitle><jtitle>Archives of dermatology (1960)</jtitle><addtitle>Arch Dermatol</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>134</volume><issue>10</issue><spage>1216</spage><epage>1220</epage><pages>1216-1220</pages><issn>0003-987X</issn><issn>2168-6068</issn><eissn>1538-3652</eissn><eissn>2168-6084</eissn><coden>ARDEAC</coden><abstract><![CDATA[OBJECTIVES To study the frequency of nail changes in a population of human immunodeficiency virus (HIV)–infected patients and to evaluate the specificity of these findings by comparison with HIV-negative control subjects. DESIGN Prospective controlled study. Nail changes were recorded by a standardized clinical examination (curvature, nail plate, color, onychomycosis). In case of clinical diagnosis of onychomycosis, mycological culture was performed. SETTING Primary care university hospital. PATIENTS A total of 155 HIV-1–positive patients and 103 healthy HIV-negative control subjects of comparable age and sex ratio. INTERVENTION None. MAIN OUTCOME MEASURE Clinical examination findings. RESULTS Nail symptoms were present in 67.7% of HIV-positive patients vs 34.0% of controls (P<<.001). The following symptoms were significantly more frequent in the HIV group: clubbing (5.8%) (P<.05), transverse lines (7.1%) (P<.01), onychoschizia (7.1%) (P<.05), leukonychia (14.3%) (P<.001), and longitudinal melanonychia (14.8%) (P<.01). The main finding was onychomycosis in 30.3% of patients vs 12.6% of controls (P<.001). Trichophyton rubrum was present in 48% of onychomycoses and unusual Candida species were also recorded. Multiple fungi were frequently cultured in a single patient. The mean CD4+ cell count was lower in patients with onychomycosis and the frequency of onychomycosis increased in advanced stages of HIV disease. Acquired total leukonychia of the 20 nails was present in 4% of patients. CONCLUSION Nail symptoms are much more frequent in patients with HIV than in healthy controls, and some of them could be linked to the level of immunosuppression.-->]]></abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>9801676</pmid><doi>10.1001/archderm.134.10.1216</doi><tpages>5</tpages></addata></record> |
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| ispartof | Archives of dermatology (1960), 1998-10, Vol.134 (10), p.1216-1220 |
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| subjects | Adult Aged AIDS/HIV Biological and medical sciences Dermatology Female Hair and nails disorders HIV Infections - complications Humans Male Medical sciences Middle Aged Nail Diseases - complications Nail Diseases - epidemiology Prospective Studies |
| title | Nail Changes in Patients Infected With Human Immunodeficiency Virus: A Prospective Controlled Study |
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