Estradiol Coupling to Human Monocyte Nitric Oxide Release Is Dependent on Intracellular Calcium Transients: Evidence for an Estrogen Surface Receptor

We tested the hypothesis that estrogen acutely stimulates constitutive NO synthase (cNOS) activity in human peripheral monocytes by acting on an estrogen surface receptor. NO release was measured in real time with an amperometric probe. 17beta-estradiol exposure to monocytes stimulated NO release wi...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-10, Vol.163 (7), p.3758-3763
Hauptverfasser:	Stefano, George B, Prevot, Vincent, Beauvillain, Jean-Claude, Fimiani, Caterina, Welters, Ingeborg, Cadet, Patrick, Breton, Christophe, Pestel, Joel, Salzet, Michel, Bilfinger, Thomas V
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - blood Estradiol - blood Estradiol - physiology Estrogen Receptor alpha Estrogen Receptor beta Gene Expression Humans Intracellular Fluid - metabolism Monocytes - metabolism Nitric Oxide - blood Receptors, Estradiol - physiology Receptors, Estrogen - antagonists & inhibitors Receptors, Estrogen - biosynthesis Receptors, Estrogen - blood Receptors, Estrogen - genetics Tamoxifen - pharmacology
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