Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart

The CAMPATH-1 family of antibodies are able systematically to lyse human lymphocytes with human complement by targeting the small cell-surface glycoprotein CD52, commonly called the CAMPATH-1 antigen. These antibodies have been used clinically for several years, providing therapy for patients with a...

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Veröffentlicht in:	Journal of molecular biology 1998-11, Vol.284 (1), p.85-99
Hauptverfasser:	Cheetham, G M, Hale, G, Waldmann, H, Bloomer, A C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alemtuzumab Amino Acid Sequence Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - metabolism Antibodies, Monoclonal, Humanized Antibodies, Neoplasm - chemistry Antibodies, Neoplasm - metabolism Antigens, CD - metabolism Antigens, Neoplasm Binding Sites CD52 Antigen Crystallography, X-Ray Glycoproteins - metabolism Humans Immunoglobulin Fab Fragments - chemistry Models, Molecular Molecular Sequence Data Protein Conformation Rats
Online-Zugang:	Volltext
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