The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action

Alternative splicing of the human glucocorticoid receptor gene generates a nonhormone binding splice variant (hGRbeta) that differs from the wild-type receptor (hGRalpha) only at the carboxyl terminus. Previously we have shown that hGRbeta inhibits the transcriptional activity of hGRalpha, which is...

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Veröffentlicht in:	The Journal of biological chemistry 1999-09, Vol.274 (39), p.27857-27866
Hauptverfasser:	Oakley, R H, Jewell, C M, Yudt, M R, Bofetiado, D M, Cidlowski, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Cell Line Chloramphenicol O-Acetyltransferase - genetics COS Cells Dexamethasone - pharmacology Dimerization Gene Expression Regulation Genes, Reporter Humans Luciferases - genetics Mice Mouse mammary tumor virus NF-B protein NF-kappa B - metabolism progesterone Progesterone - pharmacology Promoter Regions, Genetic Protein Isoforms - genetics Protein Isoforms - metabolism Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Recombinant Fusion Proteins - biosynthesis Recombinant Proteins - metabolism Transcription, Genetic Transfection
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