Mutation of the Angelman Ubiquitin Ligase in Mice Causes Increased Cytoplasmic p53 and Deficits of Contextual Learning and Long-Term Potentiation

The E6-AP ubiquitin ligase (human/mouse gene UBE3A/Ube3a) promotes the degradation of p53 in association with papilloma E6 protein, and maternal deficiency causes human Angelman syndrome (AS). Ube3a is imprinted with silencing of the paternal allele in hippocampus and cerebellum in mice. We found th...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1998-10, Vol.21 (4), p.799-811
Hauptverfasser:	Jiang, Yong-hui, Armstrong, Dawna, Albrecht, Urs, Atkins, Coleen M, Noebels, Jeffrey L, Eichele, Gregor, Sweatt, J.David, Beaudet, Arthur L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Animals Association Learning - physiology Brain - metabolism Cytoplasm - metabolism Disease Models, Animal Learning Disorders - genetics Ligases - deficiency Ligases - genetics Ligases - metabolism Long-Term Potentiation - genetics Mice Motor Activity - physiology Mutation - genetics Neurons - metabolism Seizures - etiology Seizures - genetics Synapses - physiology Tumor Suppressor Protein p53 - metabolism ubiquitin ligase gene Ubiquitin-Protein Ligases
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