Association between Premorbid History of Depression and Current Depression in Alzheimer's Disease
The relationship between a premorbid history of depression and the depressive syndrome in Alzheimer's disease (AD) remains equivocal. In the current study, we compared the prevalence of depression among patients with and without a history of mood disturbance prior to the onset of dementia. The...
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| Veröffentlicht in: | Journal of geriatric psychiatry and neurology 1999-07, Vol.12 (2), p.72-75 |
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| container_title | Journal of geriatric psychiatry and neurology |
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| creator | Harwood, Dylan G. Barker, Warren W. Ownby, Raymond L. Duara, Ranjan |
| description | The relationship between a premorbid history of depression and the depressive syndrome in Alzheimer's disease (AD) remains equivocal. In the current study, we compared the prevalence of depression among patients with and without a history of mood disturbance prior to the onset of dementia. The sample comprised 243 AD outpatients evaluated consecutively at a university-affiliated memory disorders center. The results indicated that a positive history of depression was more common among patients with current depression compared to those without cur rent depression (23% vs 11%, Fisher's Exact Test, P = .03). This relationship remained significant after controlling for the effects of age, education, gender, ethnicity, and level of cognitive impairment (odds ratio = 2.6, 95% confi dence interval = 1.01-6.61, P = .04). Neither gender nor the interaction of gender and history of depression was shown to confer risk for current depressive symptoms. The present investigation suggests that premorbid depres sion may alter the risk for mood disturbance in AD. (J Geriatr Psychiatry Neurol 1999; 12:72-75). |
| doi_str_mv | 10.1177/089198879901200206 |
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In the current study, we compared the prevalence of depression among patients with and without a history of mood disturbance prior to the onset of dementia. The sample comprised 243 AD outpatients evaluated consecutively at a university-affiliated memory disorders center. The results indicated that a positive history of depression was more common among patients with current depression compared to those without cur rent depression (23% vs 11%, Fisher's Exact Test, P = .03). This relationship remained significant after controlling for the effects of age, education, gender, ethnicity, and level of cognitive impairment (odds ratio = 2.6, 95% confi dence interval = 1.01-6.61, P = .04). Neither gender nor the interaction of gender and history of depression was shown to confer risk for current depressive symptoms. The present investigation suggests that premorbid depres sion may alter the risk for mood disturbance in AD. 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In the current study, we compared the prevalence of depression among patients with and without a history of mood disturbance prior to the onset of dementia. The sample comprised 243 AD outpatients evaluated consecutively at a university-affiliated memory disorders center. The results indicated that a positive history of depression was more common among patients with current depression compared to those without cur rent depression (23% vs 11%, Fisher's Exact Test, P = .03). This relationship remained significant after controlling for the effects of age, education, gender, ethnicity, and level of cognitive impairment (odds ratio = 2.6, 95% confi dence interval = 1.01-6.61, P = .04). Neither gender nor the interaction of gender and history of depression was shown to confer risk for current depressive symptoms. The present investigation suggests that premorbid depres sion may alter the risk for mood disturbance in AD. (J Geriatr Psychiatry Neurol 1999; 12:72-75).</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - psychology</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Depressive Disorder - epidemiology</subject><subject>Depressive Disorder - etiology</subject><subject>Depressive Disorder - psychology</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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| subjects | Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - psychology Biological and medical sciences Cross-Sectional Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Depressive Disorder - epidemiology Depressive Disorder - etiology Depressive Disorder - psychology Female Geriatrics Humans Male Medical sciences Neurology Prevalence Prognosis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors |
| title | Association between Premorbid History of Depression and Current Depression in Alzheimer's Disease |
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