Binding of Dynein Light Chain (PIN) to Neuronal Nitric Oxide Synthase in the Absence of Inhibition

PIN, an 89-amino-acid polypeptide found in a rat hippocampal cDNA library using the yeast two-hybrid system and various neuronal nitric oxide synthase (nNOS) fragments as bait, was reported to be an inhibitor of nNOS (Science274, 774–778, 1996). PIN reportedly inhibited nNOS selectively and did not...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1998-11, Vol.359 (2), p.297-304
Hauptverfasser:	Rodrı́guez-Crespo, Ignacio, Straub, Wesley, Gavilanes, Francisco, Ortiz de Montellano, Paul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Carrier Proteins - genetics Carrier Proteins - metabolism Carrier Proteins - physiology Drosophila Proteins Dyneins - genetics Dyneins - metabolism Enzyme Activation - drug effects Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I Peptide Fragments - genetics Peptide Fragments - metabolism Rats Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification
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