Orexin A Activates Locus Coeruleus Cell Firing and Increases Arousal in the Rat

The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an inv...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-09, Vol.96 (19), p.10911-10916
Hauptverfasser:	Hagan, Jim J., Leslie, Ron A., Patel, Sara, Evans, Martyn L., Wattam, Trevor A., Holmes, Steve, Benham, Christopher D., Taylor, Stephen G., Routledge, Carol, Hemmati, Panida, Munton, Richard P., Ashmeade, Tracey E., Shah, Ajit S., Hatcher, Jonathan P., Hatcher, Paula D., Declan N. C. Jones, Smith, Martin I., Piper, David C., Hunter, A. Jackie, Porter, Rod A., Upton, Neil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal grooming Animals Antiserum Arousal - physiology Behavior, Animal - physiology Behavioral neuroscience Biological Sciences Brain Carrier Proteins - metabolism Carrier Proteins - pharmacology Carrier Proteins - physiology Corticosterone - metabolism Dose-Response Relationship, Drug Electroencephalography Electrophysiology Growth Hormone - metabolism Growth hormones Hypothalamus Immunohistochemistry Intracellular Signaling Peptides and Proteins Locus coeruleus Locus Coeruleus - physiology Male Maze Learning - physiology Medical research Neurology Neurons Neuropeptides - metabolism Neuropeptides - pharmacology Neuropeptides - physiology Orexins Peptides Prolactin - metabolism Rats Rats, Sprague-Dawley Rodents Sleep Sleep - physiology Time Factors
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