Orexin A Activates Locus Coeruleus Cell Firing and Increases Arousal in the Rat
The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an inv...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1999-09, Vol.96 (19), p.10911-10916 |
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| creator | Hagan, Jim J. Leslie, Ron A. Patel, Sara Evans, Martyn L. Wattam, Trevor A. Holmes, Steve Benham, Christopher D. Taylor, Stephen G. Routledge, Carol Hemmati, Panida Munton, Richard P. Ashmeade, Tracey E. Shah, Ajit S. Hatcher, Jonathan P. Hatcher, Paula D. Declan N. C. Jones Smith, Martin I. Piper, David C. Hunter, A. Jackie Porter, Rod A. Upton, Neil |
| description | The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and modulates neuroendocrine function. The data suggest that orexin A plays an important role in orchestrating the sleep-wake cycle. |
| doi_str_mv | 10.1073/pnas.96.19.10911 |
| format | Article |
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C. Jones ; Smith, Martin I. ; Piper, David C. ; Hunter, A. Jackie ; Porter, Rod A. ; Upton, Neil</creator><creatorcontrib>Hagan, Jim J. ; Leslie, Ron A. ; Patel, Sara ; Evans, Martyn L. ; Wattam, Trevor A. ; Holmes, Steve ; Benham, Christopher D. ; Taylor, Stephen G. ; Routledge, Carol ; Hemmati, Panida ; Munton, Richard P. ; Ashmeade, Tracey E. ; Shah, Ajit S. ; Hatcher, Jonathan P. ; Hatcher, Paula D. ; Declan N. C. Jones ; Smith, Martin I. ; Piper, David C. ; Hunter, A. Jackie ; Porter, Rod A. ; Upton, Neil</creatorcontrib><description>The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and modulates neuroendocrine function. The data suggest that orexin A plays an important role in orchestrating the sleep-wake cycle.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.96.19.10911</identifier><identifier>PMID: 10485925</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animal grooming ; Animals ; Antiserum ; Arousal - physiology ; Behavior, Animal - physiology ; Behavioral neuroscience ; Biological Sciences ; Brain ; Carrier Proteins - metabolism ; Carrier Proteins - pharmacology ; Carrier Proteins - physiology ; Corticosterone - metabolism ; Dose-Response Relationship, Drug ; Electroencephalography ; Electrophysiology ; Growth Hormone - metabolism ; Growth hormones ; Hypothalamus ; Immunohistochemistry ; Intracellular Signaling Peptides and Proteins ; Locus coeruleus ; Locus Coeruleus - physiology ; Male ; Maze Learning - physiology ; Medical research ; Neurology ; Neurons ; Neuropeptides - metabolism ; Neuropeptides - pharmacology ; Neuropeptides - physiology ; Orexins ; Peptides ; Prolactin - metabolism ; Rats ; Rats, Sprague-Dawley ; Rodents ; Sleep ; Sleep - physiology ; Time Factors</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1999-09, Vol.96 (19), p.10911-10916</ispartof><rights>Copyright 1993-1999 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Sep 14, 1999</rights><rights>Copyright © 1999, The National Academy of Sciences 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c639t-7d44f6cda3f42b2522e701d48af52f9f650f016a7f2723e5e3fe710d94e2cff63</citedby><cites>FETCH-LOGICAL-c639t-7d44f6cda3f42b2522e701d48af52f9f650f016a7f2723e5e3fe710d94e2cff63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/96/19.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48852$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48852$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10485925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hagan, Jim J.</creatorcontrib><creatorcontrib>Leslie, Ron A.</creatorcontrib><creatorcontrib>Patel, Sara</creatorcontrib><creatorcontrib>Evans, Martyn L.</creatorcontrib><creatorcontrib>Wattam, Trevor A.</creatorcontrib><creatorcontrib>Holmes, Steve</creatorcontrib><creatorcontrib>Benham, Christopher D.</creatorcontrib><creatorcontrib>Taylor, Stephen G.</creatorcontrib><creatorcontrib>Routledge, Carol</creatorcontrib><creatorcontrib>Hemmati, Panida</creatorcontrib><creatorcontrib>Munton, Richard P.</creatorcontrib><creatorcontrib>Ashmeade, Tracey E.</creatorcontrib><creatorcontrib>Shah, Ajit S.</creatorcontrib><creatorcontrib>Hatcher, Jonathan P.</creatorcontrib><creatorcontrib>Hatcher, Paula D.</creatorcontrib><creatorcontrib>Declan N. C. Jones</creatorcontrib><creatorcontrib>Smith, Martin I.</creatorcontrib><creatorcontrib>Piper, David C.</creatorcontrib><creatorcontrib>Hunter, A. Jackie</creatorcontrib><creatorcontrib>Porter, Rod A.</creatorcontrib><creatorcontrib>Upton, Neil</creatorcontrib><title>Orexin A Activates Locus Coeruleus Cell Firing and Increases Arousal in the Rat</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and modulates neuroendocrine function. The data suggest that orexin A plays an important role in orchestrating the sleep-wake cycle.</description><subject>Animal grooming</subject><subject>Animals</subject><subject>Antiserum</subject><subject>Arousal - physiology</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral neuroscience</subject><subject>Biological Sciences</subject><subject>Brain</subject><subject>Carrier Proteins - metabolism</subject><subject>Carrier Proteins - pharmacology</subject><subject>Carrier Proteins - physiology</subject><subject>Corticosterone - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electroencephalography</subject><subject>Electrophysiology</subject><subject>Growth Hormone - metabolism</subject><subject>Growth hormones</subject><subject>Hypothalamus</subject><subject>Immunohistochemistry</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Locus coeruleus</subject><subject>Locus Coeruleus - physiology</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Medical research</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neuropeptides - metabolism</subject><subject>Neuropeptides - pharmacology</subject><subject>Neuropeptides - physiology</subject><subject>Orexins</subject><subject>Peptides</subject><subject>Prolactin - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Sleep</subject><subject>Sleep - physiology</subject><subject>Time Factors</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFv0zAUxi3ExMrgjjiAxQFxSXl27DiWdqkqBpMqVUJwtrzkeUuVOsV2pvHf46xlKhy207P1ft8nf_4IecNgzkCVn3fexrmu5kznu2bsGZlNs6iEhudkBsBVUQsuTsnLGDcAoGUNL8gpA1FLzeWMrNcB7zpPF3TRpO7WJox0NTRjpMsBw9jjdMK-pxdd6Pw1tb6ll74JaGMmF2EYo-1pNkg3SL_b9IqcONtHfH2YZ-TnxZcfy2_Fav31crlYFU1V6lSoVghXNa0tneBXXHKOClgrauskd9pVEhywyirHFS9RYulQMWi1QN44V5Vn5Hzvuxuvttg26FOwvdmFbmvDbzPYzvy78d2NuR5uDVO65ln-8SAPw68RYzLbLjY5p_WYIxkFUAot9ZMgUwJkJesMfvgP3Axj8PkPDAdW6lrDBMEeasIQY0D38GAGZmrUTI0aXRmmzX2jWfLuOOiRYF9hBj4dgEn6d31kYdzY9wnvUkbfP45m4u2e2MQ0hAdE1LXk5R_i5r3a</recordid><startdate>19990914</startdate><enddate>19990914</enddate><creator>Hagan, Jim J.</creator><creator>Leslie, Ron A.</creator><creator>Patel, Sara</creator><creator>Evans, Martyn L.</creator><creator>Wattam, Trevor A.</creator><creator>Holmes, Steve</creator><creator>Benham, Christopher D.</creator><creator>Taylor, Stephen G.</creator><creator>Routledge, Carol</creator><creator>Hemmati, Panida</creator><creator>Munton, Richard P.</creator><creator>Ashmeade, Tracey E.</creator><creator>Shah, Ajit S.</creator><creator>Hatcher, Jonathan P.</creator><creator>Hatcher, Paula D.</creator><creator>Declan N. 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Jackie</creator><creator>Porter, Rod A.</creator><creator>Upton, Neil</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><general>The National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990914</creationdate><title>Orexin A Activates Locus Coeruleus Cell Firing and Increases Arousal in the Rat</title><author>Hagan, Jim J. ; Leslie, Ron A. ; Patel, Sara ; Evans, Martyn L. ; Wattam, Trevor A. ; Holmes, Steve ; Benham, Christopher D. ; Taylor, Stephen G. ; Routledge, Carol ; Hemmati, Panida ; Munton, Richard P. ; Ashmeade, Tracey E. ; Shah, Ajit S. ; Hatcher, Jonathan P. ; Hatcher, Paula D. ; Declan N. 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Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and modulates neuroendocrine function. The data suggest that orexin A plays an important role in orchestrating the sleep-wake cycle.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>10485925</pmid><doi>10.1073/pnas.96.19.10911</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1999-09, Vol.96 (19), p.10911-10916 |
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| subjects | Animal grooming Animals Antiserum Arousal - physiology Behavior, Animal - physiology Behavioral neuroscience Biological Sciences Brain Carrier Proteins - metabolism Carrier Proteins - pharmacology Carrier Proteins - physiology Corticosterone - metabolism Dose-Response Relationship, Drug Electroencephalography Electrophysiology Growth Hormone - metabolism Growth hormones Hypothalamus Immunohistochemistry Intracellular Signaling Peptides and Proteins Locus coeruleus Locus Coeruleus - physiology Male Maze Learning - physiology Medical research Neurology Neurons Neuropeptides - metabolism Neuropeptides - pharmacology Neuropeptides - physiology Orexins Peptides Prolactin - metabolism Rats Rats, Sprague-Dawley Rodents Sleep Sleep - physiology Time Factors |
| title | Orexin A Activates Locus Coeruleus Cell Firing and Increases Arousal in the Rat |
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