Low levels of serum inhibin A and inhibin B in women with hypergonadotropic amenorrhea and evidence of high levels of activin A in women with hypothalamic amenorrhea
Objective: To examine serum levels of inhibin A, inhibin B, and activin A in women with secondary hypergonadotropic or hypothalamic amenorrhea. Design: Retrospective study. Setting: Universities of Udine, Pisa, and Modena in Italy, and of Wien in Austria. Patient(s): Forty women with idiopathic prem...
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| Veröffentlicht in: | Fertility and sterility 1998-11, Vol.70 (5), p.907-912 |
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| container_title | Fertility and sterility |
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| creator | Petraglia, Felice Hartmann, Beda Luisi, Stefano Florio, Pasquale Kirchengast, Silvia Santuz, Massimo Genazzani, Alessandro D Genazzani, Andrea R |
| description | Objective: To examine serum levels of inhibin A, inhibin B, and activin A in women with secondary hypergonadotropic or hypothalamic amenorrhea.
Design: Retrospective study.
Setting: Universities of Udine, Pisa, and Modena in Italy, and of Wien in Austria.
Patient(s): Forty women with idiopathic premature ovarian failure (POF), 23 women with hypogonadotropic hypothalamic amenorrhea, 40 healthy postmenopausal women, and 40 age-matched women with normal ovarian function (controls).
Intervention(s): Blood samples were collected between 8 and 9
am.
Main Outcome Measure(s): Serum levels of inhibin A, inhibin B, and activin A.
Result(s): Women with POF had lower concentrations of serum inhibin A and inhibin B than women with hypothalamic amenorrhea and fertile controls, and the difference between these concentrations was statistically significant. Levels of inhibin A and inhibin B were low in postmenopausal women and were no different than in women with POF. Serum levels of activin A were not significantly different among women with POF, fertile controls, and postmenopausal women. Women with hypogonadotropic hypothalamic amenorrhea had higher activin A values than did controls. No significant correlation was found between the level of inhibin A or inhibin B and the length of amenorrhea or the level of FSH.
Conclusion(s): Low levels of circulating inhibins A and B, but not activin A, reflect ovarian failure in women with POF, whereas women with hypogonadotropic hypothalamic amenorrhea have normal levels of inhibins A and B and high levels of activin A. |
| doi_str_mv | 10.1016/S0015-0282(98)00283-0 |
| format | Article |
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Design: Retrospective study.
Setting: Universities of Udine, Pisa, and Modena in Italy, and of Wien in Austria.
Patient(s): Forty women with idiopathic premature ovarian failure (POF), 23 women with hypogonadotropic hypothalamic amenorrhea, 40 healthy postmenopausal women, and 40 age-matched women with normal ovarian function (controls).
Intervention(s): Blood samples were collected between 8 and 9
am.
Main Outcome Measure(s): Serum levels of inhibin A, inhibin B, and activin A.
Result(s): Women with POF had lower concentrations of serum inhibin A and inhibin B than women with hypothalamic amenorrhea and fertile controls, and the difference between these concentrations was statistically significant. Levels of inhibin A and inhibin B were low in postmenopausal women and were no different than in women with POF. Serum levels of activin A were not significantly different among women with POF, fertile controls, and postmenopausal women. Women with hypogonadotropic hypothalamic amenorrhea had higher activin A values than did controls. No significant correlation was found between the level of inhibin A or inhibin B and the length of amenorrhea or the level of FSH.
Conclusion(s): Low levels of circulating inhibins A and B, but not activin A, reflect ovarian failure in women with POF, whereas women with hypogonadotropic hypothalamic amenorrhea have normal levels of inhibins A and B and high levels of activin A.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(98)00283-0</identifier><identifier>PMID: 9806574</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>activin A ; Activins ; Adult ; Amenorrhea - blood ; Biological and medical sciences ; Estradiol - blood ; Female ; Female genital diseases ; Follicle Stimulating Hormone - blood ; Gynecology. Andrology. Obstetrics ; Humans ; hypergonadotropic amenorrhea ; hypothalamic amenorrhea ; Hypothalamic Diseases - blood ; Inhibin A ; inhibin B ; Inhibins - blood ; Luteinizing Hormone - blood ; Medical sciences ; menopause ; Middle Aged ; Non tumoral diseases ; premature ovarian failure ; Primary Ovarian Insufficiency - blood ; Protein Isoforms - blood ; Reference Values ; Retrospective Studies</subject><ispartof>Fertility and sterility, 1998-11, Vol.70 (5), p.907-912</ispartof><rights>1998 American Society for Reproductive Medicine</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-88e7cc6ba061cd1335b5a0798e5caa08833f67cdbc5ae348364c608d2d4e6d0c3</citedby><cites>FETCH-LOGICAL-c436t-88e7cc6ba061cd1335b5a0798e5caa08833f67cdbc5ae348364c608d2d4e6d0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028298002830$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2433271$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9806574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petraglia, Felice</creatorcontrib><creatorcontrib>Hartmann, Beda</creatorcontrib><creatorcontrib>Luisi, Stefano</creatorcontrib><creatorcontrib>Florio, Pasquale</creatorcontrib><creatorcontrib>Kirchengast, Silvia</creatorcontrib><creatorcontrib>Santuz, Massimo</creatorcontrib><creatorcontrib>Genazzani, Alessandro D</creatorcontrib><creatorcontrib>Genazzani, Andrea R</creatorcontrib><title>Low levels of serum inhibin A and inhibin B in women with hypergonadotropic amenorrhea and evidence of high levels of activin A in women with hypothalamic amenorrhea</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective: To examine serum levels of inhibin A, inhibin B, and activin A in women with secondary hypergonadotropic or hypothalamic amenorrhea.
Design: Retrospective study.
Setting: Universities of Udine, Pisa, and Modena in Italy, and of Wien in Austria.
Patient(s): Forty women with idiopathic premature ovarian failure (POF), 23 women with hypogonadotropic hypothalamic amenorrhea, 40 healthy postmenopausal women, and 40 age-matched women with normal ovarian function (controls).
Intervention(s): Blood samples were collected between 8 and 9
am.
Main Outcome Measure(s): Serum levels of inhibin A, inhibin B, and activin A.
Result(s): Women with POF had lower concentrations of serum inhibin A and inhibin B than women with hypothalamic amenorrhea and fertile controls, and the difference between these concentrations was statistically significant. Levels of inhibin A and inhibin B were low in postmenopausal women and were no different than in women with POF. Serum levels of activin A were not significantly different among women with POF, fertile controls, and postmenopausal women. Women with hypogonadotropic hypothalamic amenorrhea had higher activin A values than did controls. No significant correlation was found between the level of inhibin A or inhibin B and the length of amenorrhea or the level of FSH.
Conclusion(s): Low levels of circulating inhibins A and B, but not activin A, reflect ovarian failure in women with POF, whereas women with hypogonadotropic hypothalamic amenorrhea have normal levels of inhibins A and B and high levels of activin A.</description><subject>activin A</subject><subject>Activins</subject><subject>Adult</subject><subject>Amenorrhea - blood</subject><subject>Biological and medical sciences</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>hypergonadotropic amenorrhea</subject><subject>hypothalamic amenorrhea</subject><subject>Hypothalamic Diseases - blood</subject><subject>Inhibin A</subject><subject>inhibin B</subject><subject>Inhibins - blood</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>menopause</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>premature ovarian failure</subject><subject>Primary Ovarian Insufficiency - blood</subject><subject>Protein Isoforms - blood</subject><subject>Reference Values</subject><subject>Retrospective Studies</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcuO1DAQtBBoGRY-YaUcEIJDoB3HjnNCy4qXNBIH4Gw57c7GKIkHOzOr_SD-E89DIxAHLna3uqrarmLsisNrDly9-QrAZQmVrl62-hXkQpTwgK24lKqUSoqHbHWGPGZPUvoBAIo31QW7aDUo2dQr9msd7oqRdjSmIvRForidCj8PvvNzcV3Y2Z27d7kq7sJE-fTLUAz3G4q3YbYuLDFsPBY2z0KMA9kDkXbe0Yy0Fx787fDHHouL3x02_KMZlsGOdvpL7il71Nsx0bPTfcm-f3j_7eZTuf7y8fPN9brEWqil1JoaRNXZ_E10XAjZSQtNq0mitaC1EL1q0HUoLYlaC1WjAu0qV5NygOKSvTjqbmL4uaW0mMknpHG0M4VtMg1AprVVBsojEGNIKVJvNtFPNt4bDmYfjznEY_bem1abQzwGMu_qtGDbTeTOrFMeef78NLcJ7dhHO6NPZ1hVC1E1PMPeHmHZzuwyRZPQ7612PhIuxgX_n4f8BvR2ruo</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>Petraglia, Felice</creator><creator>Hartmann, Beda</creator><creator>Luisi, Stefano</creator><creator>Florio, Pasquale</creator><creator>Kirchengast, Silvia</creator><creator>Santuz, Massimo</creator><creator>Genazzani, Alessandro D</creator><creator>Genazzani, Andrea R</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981101</creationdate><title>Low levels of serum inhibin A and inhibin B in women with hypergonadotropic amenorrhea and evidence of high levels of activin A in women with hypothalamic amenorrhea</title><author>Petraglia, Felice ; Hartmann, Beda ; Luisi, Stefano ; Florio, Pasquale ; Kirchengast, Silvia ; Santuz, Massimo ; Genazzani, Alessandro D ; Genazzani, Andrea R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-88e7cc6ba061cd1335b5a0798e5caa08833f67cdbc5ae348364c608d2d4e6d0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>activin A</topic><topic>Activins</topic><topic>Adult</topic><topic>Amenorrhea - blood</topic><topic>Biological and medical sciences</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>hypergonadotropic amenorrhea</topic><topic>hypothalamic amenorrhea</topic><topic>Hypothalamic Diseases - blood</topic><topic>Inhibin A</topic><topic>inhibin B</topic><topic>Inhibins - blood</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>menopause</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>premature ovarian failure</topic><topic>Primary Ovarian Insufficiency - blood</topic><topic>Protein Isoforms - blood</topic><topic>Reference Values</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petraglia, Felice</creatorcontrib><creatorcontrib>Hartmann, Beda</creatorcontrib><creatorcontrib>Luisi, Stefano</creatorcontrib><creatorcontrib>Florio, Pasquale</creatorcontrib><creatorcontrib>Kirchengast, Silvia</creatorcontrib><creatorcontrib>Santuz, Massimo</creatorcontrib><creatorcontrib>Genazzani, Alessandro D</creatorcontrib><creatorcontrib>Genazzani, Andrea R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petraglia, Felice</au><au>Hartmann, Beda</au><au>Luisi, Stefano</au><au>Florio, Pasquale</au><au>Kirchengast, Silvia</au><au>Santuz, Massimo</au><au>Genazzani, Alessandro D</au><au>Genazzani, Andrea R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low levels of serum inhibin A and inhibin B in women with hypergonadotropic amenorrhea and evidence of high levels of activin A in women with hypothalamic amenorrhea</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>70</volume><issue>5</issue><spage>907</spage><epage>912</epage><pages>907-912</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective: To examine serum levels of inhibin A, inhibin B, and activin A in women with secondary hypergonadotropic or hypothalamic amenorrhea.
Design: Retrospective study.
Setting: Universities of Udine, Pisa, and Modena in Italy, and of Wien in Austria.
Patient(s): Forty women with idiopathic premature ovarian failure (POF), 23 women with hypogonadotropic hypothalamic amenorrhea, 40 healthy postmenopausal women, and 40 age-matched women with normal ovarian function (controls).
Intervention(s): Blood samples were collected between 8 and 9
am.
Main Outcome Measure(s): Serum levels of inhibin A, inhibin B, and activin A.
Result(s): Women with POF had lower concentrations of serum inhibin A and inhibin B than women with hypothalamic amenorrhea and fertile controls, and the difference between these concentrations was statistically significant. Levels of inhibin A and inhibin B were low in postmenopausal women and were no different than in women with POF. Serum levels of activin A were not significantly different among women with POF, fertile controls, and postmenopausal women. Women with hypogonadotropic hypothalamic amenorrhea had higher activin A values than did controls. No significant correlation was found between the level of inhibin A or inhibin B and the length of amenorrhea or the level of FSH.
Conclusion(s): Low levels of circulating inhibins A and B, but not activin A, reflect ovarian failure in women with POF, whereas women with hypogonadotropic hypothalamic amenorrhea have normal levels of inhibins A and B and high levels of activin A.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9806574</pmid><doi>10.1016/S0015-0282(98)00283-0</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | activin A Activins Adult Amenorrhea - blood Biological and medical sciences Estradiol - blood Female Female genital diseases Follicle Stimulating Hormone - blood Gynecology. Andrology. Obstetrics Humans hypergonadotropic amenorrhea hypothalamic amenorrhea Hypothalamic Diseases - blood Inhibin A inhibin B Inhibins - blood Luteinizing Hormone - blood Medical sciences menopause Middle Aged Non tumoral diseases premature ovarian failure Primary Ovarian Insufficiency - blood Protein Isoforms - blood Reference Values Retrospective Studies |
| title | Low levels of serum inhibin A and inhibin B in women with hypergonadotropic amenorrhea and evidence of high levels of activin A in women with hypothalamic amenorrhea |
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