Interleukin-10 in Epstein-Barr virus-associated post-transplant lymphomas
We used enzyme‐linked immunosorbent assays (ELISA) to investigate the presence of interleukin‐10 (IL‐10) in the serum of patients developing post‐transplant lymphomas. Serum IL‐10 was detected in 14 out of 19 cases with a lymphoma or Hodgkin's disease, with higher values being observed in patie...
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| Veröffentlicht in: | Clinical transplantation 1999-08, Vol.13 (4), p.305-312 |
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| creator | Garnier, Jeanne-Luce Blanc-Brunat, Nelly Vivier, Geneviève Rousset, Françoise Touraine, Jean-Louis |
| description | We used enzyme‐linked immunosorbent assays (ELISA) to investigate the presence of interleukin‐10 (IL‐10) in the serum of patients developing post‐transplant lymphomas. Serum IL‐10 was detected in 14 out of 19 cases with a lymphoma or Hodgkin's disease, with higher values being observed in patients who had developed a lymphoma within the first few months post‐transplantation, and who had an aggressive form of the disease. Eleven out of the 14 patients in whom IL‐10 was detected had Epstein–Barr virus‐positive tumors. And 11 out of 14 patients died of lymphomas. In most of the patients who had detectable IL‐10 at the time of diagnosis of the lymphoma, the IL‐10 had not been present previously, but it was found in the serum of 7 out of 9 dialysis patients, and in 8 out of 17 stable transplant patients. We conclude that IL‐10 plays a role in the development of the more severe forms of post‐transplant lymphomas, and may be secreted by tumor cells. However, data from patients with chronic renal failure or patients undergoing immunosuppressive therapy must be treated with caution. |
| doi_str_mv | 10.1034/j.1399-0012.1999.130405.x |
| format | Article |
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Serum IL‐10 was detected in 14 out of 19 cases with a lymphoma or Hodgkin's disease, with higher values being observed in patients who had developed a lymphoma within the first few months post‐transplantation, and who had an aggressive form of the disease. Eleven out of the 14 patients in whom IL‐10 was detected had Epstein–Barr virus‐positive tumors. And 11 out of 14 patients died of lymphomas. In most of the patients who had detectable IL‐10 at the time of diagnosis of the lymphoma, the IL‐10 had not been present previously, but it was found in the serum of 7 out of 9 dialysis patients, and in 8 out of 17 stable transplant patients. We conclude that IL‐10 plays a role in the development of the more severe forms of post‐transplant lymphomas, and may be secreted by tumor cells. However, data from patients with chronic renal failure or patients undergoing immunosuppressive therapy must be treated with caution.</description><identifier>ISSN: 0902-0063</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1034/j.1399-0012.1999.130405.x</identifier><identifier>PMID: 10485371</identifier><language>eng</language><publisher>Copenhagen: Munksgaard International Publishers</publisher><subject>B-cell lymphomas ; Biological and medical sciences ; Burkitt Lymphoma - blood ; Burkitt Lymphoma - etiology ; Burkitt Lymphoma - virology ; cytokines ; EBV latency and replication ; Enzyme-Linked Immunosorbent Assay ; Genes, Viral ; Herpesvirus 4, Human - isolation & purification ; Hodgkin's disease ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Interleukin-10 - blood ; Kidney Failure, Chronic - blood ; Kidney Transplantation - adverse effects ; Medical sciences ; Middle Aged ; Miscellaneous ; organ transplantation ; Prognosis ; Surgery (general aspects). 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Serum IL‐10 was detected in 14 out of 19 cases with a lymphoma or Hodgkin's disease, with higher values being observed in patients who had developed a lymphoma within the first few months post‐transplantation, and who had an aggressive form of the disease. Eleven out of the 14 patients in whom IL‐10 was detected had Epstein–Barr virus‐positive tumors. And 11 out of 14 patients died of lymphomas. In most of the patients who had detectable IL‐10 at the time of diagnosis of the lymphoma, the IL‐10 had not been present previously, but it was found in the serum of 7 out of 9 dialysis patients, and in 8 out of 17 stable transplant patients. We conclude that IL‐10 plays a role in the development of the more severe forms of post‐transplant lymphomas, and may be secreted by tumor cells. However, data from patients with chronic renal failure or patients undergoing immunosuppressive therapy must be treated with caution.</description><subject>B-cell lymphomas</subject><subject>Biological and medical sciences</subject><subject>Burkitt Lymphoma - blood</subject><subject>Burkitt Lymphoma - etiology</subject><subject>Burkitt Lymphoma - virology</subject><subject>cytokines</subject><subject>EBV latency and replication</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Genes, Viral</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Hodgkin's disease</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Interleukin-10 - blood</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>organ transplantation</subject><subject>Prognosis</subject><subject>Surgery (general aspects). 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Graft diseases</subject><subject>Tumor Virus Infections - blood</subject><subject>Tumor Virus Infections - etiology</subject><issn>0902-0063</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EokvLV0BBQr1lmYkTJ74Bq7asVLVqVYTExXIcR3ibf3iSsvvtcZRV4cjJM-M3z08_M_YeYY3A04-7NXIpYwBM1iilDC2kkK33L9jq-eYlW4GEJNSCn7A3RLswFSiy1-wEIS0ynuOKbbfdaH1jp0fXxQiR66KLgUYbui_a--jJ-YliTdQbp0dbRUNPYzx63dHQ6G6MmkM7_OxbTWfsVa0bsm-P5yn7dnnxsPkaX99ebTefr2OT8jyLE12VujAcEBATg6LgZSpRpEZwzTNeWxMmEouqriCtyqLMMsS8KIS0uQ0ep-x88R18_2uyNKrWkbFNSGP7iVQOwHmeiCCUi9D4nsjbWg3etdofFIKaOaqdmmmpmZaaOaqFo9qH3XfHR6aytdU_mwu4IPhwFGgyuqkDEOPor05iLsUc9tMi--0ae_j_AGrzcL_UwSJeLFz4lv2zhfaPSuSBqPp-c6WSuzv4cXnD1T3_A4yZnSs</recordid><startdate>199908</startdate><enddate>199908</enddate><creator>Garnier, Jeanne-Luce</creator><creator>Blanc-Brunat, Nelly</creator><creator>Vivier, Geneviève</creator><creator>Rousset, Françoise</creator><creator>Touraine, Jean-Louis</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199908</creationdate><title>Interleukin-10 in Epstein-Barr virus-associated post-transplant lymphomas</title><author>Garnier, Jeanne-Luce ; Blanc-Brunat, Nelly ; Vivier, Geneviève ; Rousset, Françoise ; Touraine, Jean-Louis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4375-2adba8c3010112c1683b49164c63a353fec83b918dfd04db8b551178869e7ec43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>B-cell lymphomas</topic><topic>Biological and medical sciences</topic><topic>Burkitt Lymphoma - blood</topic><topic>Burkitt Lymphoma - etiology</topic><topic>Burkitt Lymphoma - virology</topic><topic>cytokines</topic><topic>EBV latency and replication</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Genes, Viral</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Hodgkin's disease</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Interleukin-10 - blood</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>organ transplantation</topic><topic>Prognosis</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tumor Virus Infections - blood</topic><topic>Tumor Virus Infections - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garnier, Jeanne-Luce</creatorcontrib><creatorcontrib>Blanc-Brunat, Nelly</creatorcontrib><creatorcontrib>Vivier, Geneviève</creatorcontrib><creatorcontrib>Rousset, Françoise</creatorcontrib><creatorcontrib>Touraine, Jean-Louis</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garnier, Jeanne-Luce</au><au>Blanc-Brunat, Nelly</au><au>Vivier, Geneviève</au><au>Rousset, Françoise</au><au>Touraine, Jean-Louis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-10 in Epstein-Barr virus-associated post-transplant lymphomas</atitle><jtitle>Clinical transplantation</jtitle><addtitle>J Clin Transplant</addtitle><date>1999-08</date><risdate>1999</risdate><volume>13</volume><issue>4</issue><spage>305</spage><epage>312</epage><pages>305-312</pages><issn>0902-0063</issn><eissn>1399-0012</eissn><abstract>We used enzyme‐linked immunosorbent assays (ELISA) to investigate the presence of interleukin‐10 (IL‐10) in the serum of patients developing post‐transplant lymphomas. Serum IL‐10 was detected in 14 out of 19 cases with a lymphoma or Hodgkin's disease, with higher values being observed in patients who had developed a lymphoma within the first few months post‐transplantation, and who had an aggressive form of the disease. Eleven out of the 14 patients in whom IL‐10 was detected had Epstein–Barr virus‐positive tumors. And 11 out of 14 patients died of lymphomas. In most of the patients who had detectable IL‐10 at the time of diagnosis of the lymphoma, the IL‐10 had not been present previously, but it was found in the serum of 7 out of 9 dialysis patients, and in 8 out of 17 stable transplant patients. We conclude that IL‐10 plays a role in the development of the more severe forms of post‐transplant lymphomas, and may be secreted by tumor cells. 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| ispartof | Clinical transplantation, 1999-08, Vol.13 (4), p.305-312 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | B-cell lymphomas Biological and medical sciences Burkitt Lymphoma - blood Burkitt Lymphoma - etiology Burkitt Lymphoma - virology cytokines EBV latency and replication Enzyme-Linked Immunosorbent Assay Genes, Viral Herpesvirus 4, Human - isolation & purification Hodgkin's disease Humans Immunohistochemistry In Situ Hybridization Interleukin-10 - blood Kidney Failure, Chronic - blood Kidney Transplantation - adverse effects Medical sciences Middle Aged Miscellaneous organ transplantation Prognosis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tumor Virus Infections - blood Tumor Virus Infections - etiology |
| title | Interleukin-10 in Epstein-Barr virus-associated post-transplant lymphomas |
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