Differences in the effectiveness of delivery of B- and CTL-epitopes incorporated into the Hepatitis B core antigen (HBcAg) c/e1-region

Work from a number of laboratories including our own has shown that foreign B-epitopes inserted into the c/e1-region of Hepatitis B core antigen (HBcAg) elicit powerful antibody responses when mice are immunised with the recombinant core particles. In the present study, we wished to take advantage o...

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Veröffentlicht in:	Archives of virology 1999-01, Vol.144 (7), p.1323-1343
Hauptverfasser:	Street, M, Herd, K, Londono, P, Doan, T, Dougan, G, Kast, W. M, Tindle, R. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigen presentation Antigen processing Antigens Biological and medical sciences Core particles Core protein cytotoxic T-lymphocytes Cytotoxicity E7 protein Epitopes Epitopes, B-Lymphocyte Epitopes, T-Lymphocyte Fundamental and applied biological sciences. Psychology H-2 Antigens - immunology Hepatitis Hepatitis B Hepatitis B core antigen Hepatitis B Core Antigens - immunology Hepatitis B Vaccines - immunology HLA-A Antigens - immunology Human papillomavirus humans Hydrophobicity Immune system Immunization Immunodominance Lymphocytes T Mice Mice, Inbred C57BL Mice, Transgenic Microbiology Molecular Sequence Data Papillomaviridae Plasmids Recombinant Proteins - immunology Salmonella - genetics Salmonella - immunology Salmonella typhimurium Sensory neurons T-Lymphocytes, Cytotoxic - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - immunology Virology
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