Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-kappaB

IL-12 is a 75-kDa heterodimeric cytokine composed of two covalently linked p35 and p40 chains. This pro-inflammatory cytokine plays a prominent role in the development of Th1 cell-mediated immune responses. Th1 cell-mediated immune responses have been implicated in the pathogenesis of chronic inflam...

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Veröffentlicht in:	European journal of immunology 1998-10, Vol.28 (10), p.3205-3213
Hauptverfasser:	Mazzeo, D, Panina-Bordignon, P, Recalde, H, Sinigaglia, F, D'Ambrosio, D
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Aspirin - pharmacology Cell Differentiation - drug effects Cell Line Gene Expression Regulation - drug effects Humans Interleukin-12 - biosynthesis Interleukin-12 - genetics Mice NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Th1 Cells - drug effects Th1 Cells - metabolism Transcription, Genetic - drug effects
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