Prolonged Ciprofloxacin Therapy Fails to Prevent Reactivation Tuberculosis
Recently, tuberculosis that is resistant to several first-line drugs (multidrug-resistant tuberculosis [MDR-TB]) has been transmitted, and it has caused symptomatic and asymptomatic latent infections. Isoniazid and rifampin are both effective as prophylaxis for symptomatic reactivation tuberculosis...
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| Veröffentlicht in: | Clinical infectious diseases 1998-10, Vol.27 (4), p.913-914 |
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| container_title | Clinical infectious diseases |
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| creator | Lalonde, Richard G. Barkun, Jeffrey |
| description | Recently, tuberculosis that is resistant to several first-line drugs (multidrug-resistant tuberculosis [MDR-TB]) has been transmitted, and it has caused symptomatic and asymptomatic latent infections. Isoniazid and rifampin are both effective as prophylaxis for symptomatic reactivation tuberculosis in individuals whose tuberculin skin tests are positive (a manifestation of latent tuberculosis). However, isoniazid therapy usually fails to prevent reactivation when the infecting strain is resistant to the agent. Other drugs, including quinolones, have been advocated for chemoprophylaxis in individuals who have been exposed to MDR-TB. We describe a case of reactivation tuberculosis in which, in our opinion, 4 years of continuous ciprofloxacin treatment, that had been used for suppression of recurrent ascending cholangitis, failed to prevent reactivation. |
| doi_str_mv | 10.1086/517174 |
| format | Article |
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Isoniazid and rifampin are both effective as prophylaxis for symptomatic reactivation tuberculosis in individuals whose tuberculin skin tests are positive (a manifestation of latent tuberculosis). However, isoniazid therapy usually fails to prevent reactivation when the infecting strain is resistant to the agent. Other drugs, including quinolones, have been advocated for chemoprophylaxis in individuals who have been exposed to MDR-TB. 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Isoniazid and rifampin are both effective as prophylaxis for symptomatic reactivation tuberculosis in individuals whose tuberculin skin tests are positive (a manifestation of latent tuberculosis). However, isoniazid therapy usually fails to prevent reactivation when the infecting strain is resistant to the agent. Other drugs, including quinolones, have been advocated for chemoprophylaxis in individuals who have been exposed to MDR-TB. We describe a case of reactivation tuberculosis in which, in our opinion, 4 years of continuous ciprofloxacin treatment, that had been used for suppression of recurrent ascending cholangitis, failed to prevent reactivation.</description><subject>Aged</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Antituberculars</subject><subject>Biological and medical sciences</subject><subject>Brief Reports</subject><subject>Chemoprevention</subject><subject>Cholangitis</subject><subject>Ciprofloxacin - therapeutic use</subject><subject>Humans</subject><subject>Latent tuberculosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multidrug resistant tuberculosis</subject><subject>Mycobacterium tuberculosis</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulmonary tuberculosis</subject><subject>Quinolones</subject><subject>Recurrence</subject><subject>Skin tests</subject><subject>Time Factors</subject><subject>Tuberculin</subject><subject>Tuberculosis, Pulmonary - prevention & control</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFrFDEQx4MotVb9BAr7IL6tZjY7m-RRDs96HFikVvElZHMTTd3bXJPd0n57I3dcH32agd-PP8N_GHsJ_B1w1b1HkCDbR-wUUMi6Qw2Py85R1a0S6il7lvM15wCK4wk70VIr3uEpW12kOMTxF22qRdil6Id4Z10Yq8vflOzuvlraMORqitVFolsap-orWTeFWzuFWKy5p-TmIeaQn7Mn3g6ZXhzmGfu2_Hi5OK_XXz59XnxY105oMdUCWhTQIWrSIPWm55LKWapF7_sNCEGud9xzKZDa3mEHUnnek1XgXaMbccbe7nPLuTcz5clsQ3Y0DHakOGcjOW-0avC_IshGc8HVg-hSzDmRN7sUtjbdG-DmX7tm324RXx8S535Lm6N2qLPwNwdus7ODT3Z0IT-kocLykqK92mvXeYrpiNtWlV5kwfUehzzR3RHb9Md0Ukg05z9-miVcfV-vcGWuxF-uG5iM</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>Lalonde, Richard G.</creator><creator>Barkun, Jeffrey</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19981001</creationdate><title>Prolonged Ciprofloxacin Therapy Fails to Prevent Reactivation Tuberculosis</title><author>Lalonde, Richard G. ; Barkun, Jeffrey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-3145316559e9179db07e118845ffbd133ecbc0f0735e4bc56178f0bea81fc2923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aged</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics. 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Drug treatments</topic><topic>Pulmonary tuberculosis</topic><topic>Quinolones</topic><topic>Recurrence</topic><topic>Skin tests</topic><topic>Time Factors</topic><topic>Tuberculin</topic><topic>Tuberculosis, Pulmonary - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lalonde, Richard G.</creatorcontrib><creatorcontrib>Barkun, Jeffrey</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lalonde, Richard G.</au><au>Barkun, Jeffrey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolonged Ciprofloxacin Therapy Fails to Prevent Reactivation Tuberculosis</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>27</volume><issue>4</issue><spage>913</spage><epage>914</epage><pages>913-914</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Recently, tuberculosis that is resistant to several first-line drugs (multidrug-resistant tuberculosis [MDR-TB]) has been transmitted, and it has caused symptomatic and asymptomatic latent infections. Isoniazid and rifampin are both effective as prophylaxis for symptomatic reactivation tuberculosis in individuals whose tuberculin skin tests are positive (a manifestation of latent tuberculosis). However, isoniazid therapy usually fails to prevent reactivation when the infecting strain is resistant to the agent. Other drugs, including quinolones, have been advocated for chemoprophylaxis in individuals who have been exposed to MDR-TB. We describe a case of reactivation tuberculosis in which, in our opinion, 4 years of continuous ciprofloxacin treatment, that had been used for suppression of recurrent ascending cholangitis, failed to prevent reactivation.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>9798065</pmid><doi>10.1086/517174</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 1998-10, Vol.27 (4), p.913-914 |
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| language | eng |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Anti-Infective Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - therapeutic use Antituberculars Biological and medical sciences Brief Reports Chemoprevention Cholangitis Ciprofloxacin - therapeutic use Humans Latent tuberculosis Male Medical sciences Multidrug resistant tuberculosis Mycobacterium tuberculosis Pharmacology. Drug treatments Pulmonary tuberculosis Quinolones Recurrence Skin tests Time Factors Tuberculin Tuberculosis, Pulmonary - prevention & control |
| title | Prolonged Ciprofloxacin Therapy Fails to Prevent Reactivation Tuberculosis |
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