Retinoic Acid Hydroxylase (CYP26) Is a Key Enzyme in Neuronal Differentiation of Embryonal Carcinoma Cells

Besides nuclear retinoid receptors and cellular retinoid binding proteins also retinoic acid (RA)-synthesizing enzymes (using all-trans-retinal as substrate) and RA-catabolizing enzymes (producing hydroxylated products) may explain the specific effects of retinoids. In the past we have established a...

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Veröffentlicht in:	Developmental biology 1999-09, Vol.213 (2), p.390-404
Hauptverfasser:	Sonneveld, Edwin, van den Brink, Christina E., Tertoolen, Leon G.J., van der Burg, Bart, van der Saag, Paul T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Embryonal - pathology Carcinoma, Embryonal - physiopathology Cell Differentiation - physiology CYP26 Cytochrome P-450 Enzyme System - physiology embryonal carcinoma Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic Humans Mice neuronal Neurons - pathology Neurons - physiology P450 Retinoic Acid 4-Hydroxylase retinoid Transfection Tumor Cells, Cultured
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